Four New Depsides Isolated from Salvia miltiorrhiza and Their Significant Nerve-Protective Activities

By investigating of the roots of Salvia miltiorrhiza, which is one of the most widely used Chinese herbs, we used phytochemical methods successfully to obtain twelve depsides: four depsides (1–4) that were previously undescribed, along with eight known ones (5–12). Their structure characteristics we...

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Detalles Bibliográficos
Autores principales: Jin, Qinghao, Hu, Xinyi, Deng, Yanping, Hou, Jinjun, Lei, Min, Ji, Hongjian, Zhou, Jing, Qu, Hua, Wu, Wanying, Guo, Dean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320994/
https://www.ncbi.nlm.nih.gov/pubmed/30544925
http://dx.doi.org/10.3390/molecules23123274
Descripción
Sumario:By investigating of the roots of Salvia miltiorrhiza, which is one of the most widely used Chinese herbs, we used phytochemical methods successfully to obtain twelve depsides: four depsides (1–4) that were previously undescribed, along with eight known ones (5–12). Their structure characteristics were assessed by HR-ESIMS, CD, NMR ((1)H, (13)C, HSQC, HMBC) data analyses. These four newly isolated compounds (1–4), as well as the other eight compounds (5–12), show extraordinary protective effects on hydrogen peroxide-induced apoptosis in HS-SY5Y cells. Among them, depside 4 and depside 6 displayed more obviously protective effects than others.

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