Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole

Compounds containing 1,3,4-oxadiazole ring in their structure are characterised by multidirectional biological activity. Their anti-proliferative effects associated with various mechanisms, such as inhibition of growth factors, enzymes, kinases and others, deserve attention. The activity of these co...

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Detalles Bibliográficos
Autores principales: Glomb, Teresa, Szymankiewicz, Karolina, Świątek, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320996/
https://www.ncbi.nlm.nih.gov/pubmed/30567416
http://dx.doi.org/10.3390/molecules23123361
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author Glomb, Teresa
Szymankiewicz, Karolina
Świątek, Piotr
author_facet Glomb, Teresa
Szymankiewicz, Karolina
Świątek, Piotr
author_sort Glomb, Teresa
collection PubMed
description Compounds containing 1,3,4-oxadiazole ring in their structure are characterised by multidirectional biological activity. Their anti-proliferative effects associated with various mechanisms, such as inhibition of growth factors, enzymes, kinases and others, deserve attention. The activity of these compounds was tested on cell lines of various cancers. In most publications, the most active derivatives of 1,3,4-oxadiazole exceeded the effect of reference drugs, so they may become the main new anti-cancer drugs in the future.
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spelling pubmed-63209962019-01-14 Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole Glomb, Teresa Szymankiewicz, Karolina Świątek, Piotr Molecules Review Compounds containing 1,3,4-oxadiazole ring in their structure are characterised by multidirectional biological activity. Their anti-proliferative effects associated with various mechanisms, such as inhibition of growth factors, enzymes, kinases and others, deserve attention. The activity of these compounds was tested on cell lines of various cancers. In most publications, the most active derivatives of 1,3,4-oxadiazole exceeded the effect of reference drugs, so they may become the main new anti-cancer drugs in the future. MDPI 2018-12-18 /pmc/articles/PMC6320996/ /pubmed/30567416 http://dx.doi.org/10.3390/molecules23123361 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Glomb, Teresa
Szymankiewicz, Karolina
Świątek, Piotr
Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole
title Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole
title_full Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole
title_fullStr Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole
title_full_unstemmed Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole
title_short Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole
title_sort anti-cancer activity of derivatives of 1,3,4-oxadiazole
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320996/
https://www.ncbi.nlm.nih.gov/pubmed/30567416
http://dx.doi.org/10.3390/molecules23123361
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