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Cyclodextrin-Based Metal-Organic Frameworks (CD-MOFs) in Pharmaceutics and Biomedicine

Metal-organic frameworks (MOFs) show promising application in biomedicine and pharmaceutics owing to their extraordinarily high surface area, tunable pore size, and adjustable internal surface properties. However, MOFs are prepared from non-renewable or toxic materials, which limit their real-world...

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Autores principales: Han, Yaoyao, Liu, Weicong, Huang, Jianjing, Qiu, Shuowen, Zhong, Huarui, Liu, Dong, Liu, Jianqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321025/
https://www.ncbi.nlm.nih.gov/pubmed/30545114
http://dx.doi.org/10.3390/pharmaceutics10040271
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author Han, Yaoyao
Liu, Weicong
Huang, Jianjing
Qiu, Shuowen
Zhong, Huarui
Liu, Dong
Liu, Jianqiang
author_facet Han, Yaoyao
Liu, Weicong
Huang, Jianjing
Qiu, Shuowen
Zhong, Huarui
Liu, Dong
Liu, Jianqiang
author_sort Han, Yaoyao
collection PubMed
description Metal-organic frameworks (MOFs) show promising application in biomedicine and pharmaceutics owing to their extraordinarily high surface area, tunable pore size, and adjustable internal surface properties. However, MOFs are prepared from non-renewable or toxic materials, which limit their real-world applications. Cyclodextrins (CDs) are a typical natural and biodegradable cyclic oligosaccharide and are primarily used to enhance the aqueous solubility, safety, and bioavailability of drugs by virtue of its low toxicity and highly flexible structure, offering a peculiar ability to form CD/drug inclusions. A sophisticated strategy where CD is deployed as a ligand to form an assembly of cyclodextrin-based MOFs (CD-MOFs) may overcome real-world application drawbacks of MOFs. CD-MOFs incorporate the porous features of MOFs and the encapsulation capability of CD for drug molecules, leading to outstanding properties when compared with traditional hybrid materials. This review focuses on the inclusion technology and drug delivery properties associated with CD-MOFs. In addition, synthetic strategies and currently developed uses of CD-MOFs are highlighted as well. Also, perspectives and future challenges in this rapidly developing research area are discussed.
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spelling pubmed-63210252019-01-11 Cyclodextrin-Based Metal-Organic Frameworks (CD-MOFs) in Pharmaceutics and Biomedicine Han, Yaoyao Liu, Weicong Huang, Jianjing Qiu, Shuowen Zhong, Huarui Liu, Dong Liu, Jianqiang Pharmaceutics Review Metal-organic frameworks (MOFs) show promising application in biomedicine and pharmaceutics owing to their extraordinarily high surface area, tunable pore size, and adjustable internal surface properties. However, MOFs are prepared from non-renewable or toxic materials, which limit their real-world applications. Cyclodextrins (CDs) are a typical natural and biodegradable cyclic oligosaccharide and are primarily used to enhance the aqueous solubility, safety, and bioavailability of drugs by virtue of its low toxicity and highly flexible structure, offering a peculiar ability to form CD/drug inclusions. A sophisticated strategy where CD is deployed as a ligand to form an assembly of cyclodextrin-based MOFs (CD-MOFs) may overcome real-world application drawbacks of MOFs. CD-MOFs incorporate the porous features of MOFs and the encapsulation capability of CD for drug molecules, leading to outstanding properties when compared with traditional hybrid materials. This review focuses on the inclusion technology and drug delivery properties associated with CD-MOFs. In addition, synthetic strategies and currently developed uses of CD-MOFs are highlighted as well. Also, perspectives and future challenges in this rapidly developing research area are discussed. MDPI 2018-12-12 /pmc/articles/PMC6321025/ /pubmed/30545114 http://dx.doi.org/10.3390/pharmaceutics10040271 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Han, Yaoyao
Liu, Weicong
Huang, Jianjing
Qiu, Shuowen
Zhong, Huarui
Liu, Dong
Liu, Jianqiang
Cyclodextrin-Based Metal-Organic Frameworks (CD-MOFs) in Pharmaceutics and Biomedicine
title Cyclodextrin-Based Metal-Organic Frameworks (CD-MOFs) in Pharmaceutics and Biomedicine
title_full Cyclodextrin-Based Metal-Organic Frameworks (CD-MOFs) in Pharmaceutics and Biomedicine
title_fullStr Cyclodextrin-Based Metal-Organic Frameworks (CD-MOFs) in Pharmaceutics and Biomedicine
title_full_unstemmed Cyclodextrin-Based Metal-Organic Frameworks (CD-MOFs) in Pharmaceutics and Biomedicine
title_short Cyclodextrin-Based Metal-Organic Frameworks (CD-MOFs) in Pharmaceutics and Biomedicine
title_sort cyclodextrin-based metal-organic frameworks (cd-mofs) in pharmaceutics and biomedicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321025/
https://www.ncbi.nlm.nih.gov/pubmed/30545114
http://dx.doi.org/10.3390/pharmaceutics10040271
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