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Differential Metabolic Responses to Adipose Atrophy Associated with Cancer Cachexia and Caloric Restriction in Rats and the Effect of Rikkunshito in Cancer Cachexia
Despite the similar phenotypes, including weight loss, reduction of food intake, and lower adiposity, associated with caloric restriction (CR) and cancer cachexia (CC), CC is a progressive wasting syndrome, while mild CR improves whole body metabolism. In the present study, we compared adipose metab...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321026/ https://www.ncbi.nlm.nih.gov/pubmed/30513935 http://dx.doi.org/10.3390/ijms19123852 |
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author | Sudo, Yuka Otsuka, Hiroki Miyakawa, Ryota Goto, Akifumi Kashiwase, Yohei Terawaki, Kiyoshi Miyano, Kanako Hirao, Yuto Taki, Kanari Tagawa, Ryoma Kobayashi, Masaki Okita, Naoyuki Uezono, Yasuhito Higami, Yoshikazu |
author_facet | Sudo, Yuka Otsuka, Hiroki Miyakawa, Ryota Goto, Akifumi Kashiwase, Yohei Terawaki, Kiyoshi Miyano, Kanako Hirao, Yuto Taki, Kanari Tagawa, Ryoma Kobayashi, Masaki Okita, Naoyuki Uezono, Yasuhito Higami, Yoshikazu |
author_sort | Sudo, Yuka |
collection | PubMed |
description | Despite the similar phenotypes, including weight loss, reduction of food intake, and lower adiposity, associated with caloric restriction (CR) and cancer cachexia (CC), CC is a progressive wasting syndrome, while mild CR improves whole body metabolism. In the present study, we compared adipose metabolic changes in a novel rat model of CC, mild CR (70% of the food intake of control rats, which is similar to the food consumption of CC rats), and severe CR (30% of the food intake of controls). We show that CC and severe CR are associated with much smaller adipocytes with significantly lower mitochondrial DNA content; but, that mild CR is not. CC and both mild and severe CR similarly upregulated proteins involved in lipolysis. CC also downregulated proteins involved in fatty acid biosynthesis, but mild CR upregulated these. These findings suggest that CC might impair de novo fatty acid biosynthesis and reduce mitochondrial biogenesis, similar to severe CR. We also found that rikkunshito, a traditional Japanese herbal medicine, does not ameliorate the enhanced lipolysis and mitochondrial impairment, but rather, rescues de novo fatty acid biosynthesis, suggesting that rikkunshito administration might have partially similar effects to mild CR. |
format | Online Article Text |
id | pubmed-6321026 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63210262019-01-07 Differential Metabolic Responses to Adipose Atrophy Associated with Cancer Cachexia and Caloric Restriction in Rats and the Effect of Rikkunshito in Cancer Cachexia Sudo, Yuka Otsuka, Hiroki Miyakawa, Ryota Goto, Akifumi Kashiwase, Yohei Terawaki, Kiyoshi Miyano, Kanako Hirao, Yuto Taki, Kanari Tagawa, Ryoma Kobayashi, Masaki Okita, Naoyuki Uezono, Yasuhito Higami, Yoshikazu Int J Mol Sci Article Despite the similar phenotypes, including weight loss, reduction of food intake, and lower adiposity, associated with caloric restriction (CR) and cancer cachexia (CC), CC is a progressive wasting syndrome, while mild CR improves whole body metabolism. In the present study, we compared adipose metabolic changes in a novel rat model of CC, mild CR (70% of the food intake of control rats, which is similar to the food consumption of CC rats), and severe CR (30% of the food intake of controls). We show that CC and severe CR are associated with much smaller adipocytes with significantly lower mitochondrial DNA content; but, that mild CR is not. CC and both mild and severe CR similarly upregulated proteins involved in lipolysis. CC also downregulated proteins involved in fatty acid biosynthesis, but mild CR upregulated these. These findings suggest that CC might impair de novo fatty acid biosynthesis and reduce mitochondrial biogenesis, similar to severe CR. We also found that rikkunshito, a traditional Japanese herbal medicine, does not ameliorate the enhanced lipolysis and mitochondrial impairment, but rather, rescues de novo fatty acid biosynthesis, suggesting that rikkunshito administration might have partially similar effects to mild CR. MDPI 2018-12-03 /pmc/articles/PMC6321026/ /pubmed/30513935 http://dx.doi.org/10.3390/ijms19123852 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sudo, Yuka Otsuka, Hiroki Miyakawa, Ryota Goto, Akifumi Kashiwase, Yohei Terawaki, Kiyoshi Miyano, Kanako Hirao, Yuto Taki, Kanari Tagawa, Ryoma Kobayashi, Masaki Okita, Naoyuki Uezono, Yasuhito Higami, Yoshikazu Differential Metabolic Responses to Adipose Atrophy Associated with Cancer Cachexia and Caloric Restriction in Rats and the Effect of Rikkunshito in Cancer Cachexia |
title | Differential Metabolic Responses to Adipose Atrophy Associated with Cancer Cachexia and Caloric Restriction in Rats and the Effect of Rikkunshito in Cancer Cachexia |
title_full | Differential Metabolic Responses to Adipose Atrophy Associated with Cancer Cachexia and Caloric Restriction in Rats and the Effect of Rikkunshito in Cancer Cachexia |
title_fullStr | Differential Metabolic Responses to Adipose Atrophy Associated with Cancer Cachexia and Caloric Restriction in Rats and the Effect of Rikkunshito in Cancer Cachexia |
title_full_unstemmed | Differential Metabolic Responses to Adipose Atrophy Associated with Cancer Cachexia and Caloric Restriction in Rats and the Effect of Rikkunshito in Cancer Cachexia |
title_short | Differential Metabolic Responses to Adipose Atrophy Associated with Cancer Cachexia and Caloric Restriction in Rats and the Effect of Rikkunshito in Cancer Cachexia |
title_sort | differential metabolic responses to adipose atrophy associated with cancer cachexia and caloric restriction in rats and the effect of rikkunshito in cancer cachexia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321026/ https://www.ncbi.nlm.nih.gov/pubmed/30513935 http://dx.doi.org/10.3390/ijms19123852 |
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