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The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions

Autophagy is an evolutionarily conserved cellular process in which intracellular components are eliminated via lysosomal degradation to supply nutrients for organelle biogenesis and metabolic homeostasis. Flavivirus infections underlie multiple human diseases and thus exert an immense burden on publ...

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Detalles Bibliográficos
Autor principal: Ke, Po-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321027/
https://www.ncbi.nlm.nih.gov/pubmed/30544615
http://dx.doi.org/10.3390/ijms19123940
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author Ke, Po-Yuan
author_facet Ke, Po-Yuan
author_sort Ke, Po-Yuan
collection PubMed
description Autophagy is an evolutionarily conserved cellular process in which intracellular components are eliminated via lysosomal degradation to supply nutrients for organelle biogenesis and metabolic homeostasis. Flavivirus infections underlie multiple human diseases and thus exert an immense burden on public health worldwide. Mounting evidence indicates that host autophagy is subverted to modulate the life cycles of flaviviruses, such as hepatitis C virus, dengue virus, Japanese encephalitis virus, West Nile virus and Zika virus. The diverse interplay between autophagy and flavivirus infection not only regulates viral growth in host cells but also counteracts host stress responses induced by viral infection. In this review, we summarize the current knowledge on the role of autophagy in the flavivirus life cycle. We also discuss the impacts of virus-induced autophagy on the pathogeneses of flavivirus-associated diseases and the potential use of autophagy as a therapeutic target for curing flavivirus infections and related human diseases.
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spelling pubmed-63210272019-01-07 The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions Ke, Po-Yuan Int J Mol Sci Review Autophagy is an evolutionarily conserved cellular process in which intracellular components are eliminated via lysosomal degradation to supply nutrients for organelle biogenesis and metabolic homeostasis. Flavivirus infections underlie multiple human diseases and thus exert an immense burden on public health worldwide. Mounting evidence indicates that host autophagy is subverted to modulate the life cycles of flaviviruses, such as hepatitis C virus, dengue virus, Japanese encephalitis virus, West Nile virus and Zika virus. The diverse interplay between autophagy and flavivirus infection not only regulates viral growth in host cells but also counteracts host stress responses induced by viral infection. In this review, we summarize the current knowledge on the role of autophagy in the flavivirus life cycle. We also discuss the impacts of virus-induced autophagy on the pathogeneses of flavivirus-associated diseases and the potential use of autophagy as a therapeutic target for curing flavivirus infections and related human diseases. MDPI 2018-12-07 /pmc/articles/PMC6321027/ /pubmed/30544615 http://dx.doi.org/10.3390/ijms19123940 Text en © 2018 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ke, Po-Yuan
The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions
title The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions
title_full The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions
title_fullStr The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions
title_full_unstemmed The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions
title_short The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions
title_sort multifaceted roles of autophagy in flavivirus-host interactions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321027/
https://www.ncbi.nlm.nih.gov/pubmed/30544615
http://dx.doi.org/10.3390/ijms19123940
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