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Potential Biomarkers for Predicting Congenital Cytomegalovirus Infection
Early diagnosis and treatment of infants with symptomatic congenital cytomegalovirus (CMV) infection may improve neurological outcomes. For this reason, prenatal detection of newborns at high risk for congenital CMV infection is important. A polymerase chain reaction (PCR) assay for CMV DNA in the a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321102/ https://www.ncbi.nlm.nih.gov/pubmed/30486359 http://dx.doi.org/10.3390/ijms19123760 |
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author | Tanimura, Kenji Yamada, Hideto |
author_facet | Tanimura, Kenji Yamada, Hideto |
author_sort | Tanimura, Kenji |
collection | PubMed |
description | Early diagnosis and treatment of infants with symptomatic congenital cytomegalovirus (CMV) infection may improve neurological outcomes. For this reason, prenatal detection of newborns at high risk for congenital CMV infection is important. A polymerase chain reaction (PCR) assay for CMV DNA in the amniotic fluid is the gold standard for the diagnosis of intrauterine CMV infection; however, amniocentesis is an invasive procedure. Recently, we have found that the presence of CMV DNA in the maternal uterine cervical secretion is predictive of the occurrence of congenital CMV infection in CMV immunoglobulin M (IgM)-positive pregnant women. In contrast, we have suggested that maternal serological screening for primary CMV infection using CMV-specific immunoglobulin G (IgG), the IgG avidity index, or CMV-specific IgM overlooks a number of newborns with congenital CMV infection. We will review current knowledge of the potential biomarkers for predicting congenital CMV infection. |
format | Online Article Text |
id | pubmed-6321102 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63211022019-01-07 Potential Biomarkers for Predicting Congenital Cytomegalovirus Infection Tanimura, Kenji Yamada, Hideto Int J Mol Sci Review Early diagnosis and treatment of infants with symptomatic congenital cytomegalovirus (CMV) infection may improve neurological outcomes. For this reason, prenatal detection of newborns at high risk for congenital CMV infection is important. A polymerase chain reaction (PCR) assay for CMV DNA in the amniotic fluid is the gold standard for the diagnosis of intrauterine CMV infection; however, amniocentesis is an invasive procedure. Recently, we have found that the presence of CMV DNA in the maternal uterine cervical secretion is predictive of the occurrence of congenital CMV infection in CMV immunoglobulin M (IgM)-positive pregnant women. In contrast, we have suggested that maternal serological screening for primary CMV infection using CMV-specific immunoglobulin G (IgG), the IgG avidity index, or CMV-specific IgM overlooks a number of newborns with congenital CMV infection. We will review current knowledge of the potential biomarkers for predicting congenital CMV infection. MDPI 2018-11-27 /pmc/articles/PMC6321102/ /pubmed/30486359 http://dx.doi.org/10.3390/ijms19123760 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tanimura, Kenji Yamada, Hideto Potential Biomarkers for Predicting Congenital Cytomegalovirus Infection |
title | Potential Biomarkers for Predicting Congenital Cytomegalovirus Infection |
title_full | Potential Biomarkers for Predicting Congenital Cytomegalovirus Infection |
title_fullStr | Potential Biomarkers for Predicting Congenital Cytomegalovirus Infection |
title_full_unstemmed | Potential Biomarkers for Predicting Congenital Cytomegalovirus Infection |
title_short | Potential Biomarkers for Predicting Congenital Cytomegalovirus Infection |
title_sort | potential biomarkers for predicting congenital cytomegalovirus infection |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321102/ https://www.ncbi.nlm.nih.gov/pubmed/30486359 http://dx.doi.org/10.3390/ijms19123760 |
work_keys_str_mv | AT tanimurakenji potentialbiomarkersforpredictingcongenitalcytomegalovirusinfection AT yamadahideto potentialbiomarkersforpredictingcongenitalcytomegalovirusinfection |