Characterization of a Carbonyl Reductase from Rhodococcus erythropolis WZ010 and Its Variant Y54F for Asymmetric Synthesis of (S)-N-Boc-3-Hydroxypiperidine

The recombinant carbonyl reductase from Rhodococcus erythropolis WZ010 (ReCR) demonstrated strict (S)-stereoselectivity and catalyzed the irreversible reduction of N-Boc-3-piperidone (NBPO) to (S)-N-Boc-3-hydroxypiperidine [(S)-NBHP], a key chiral intermediate in the synthesis of ibrutinib. The NAD(...

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Detalles Bibliográficos
Autores principales: Ying, Xiangxian, Zhang, Jie, Wang, Can, Huang, Meijuan, Ji, Yuting, Cheng, Feng, Yu, Meilan, Wang, Zhao, Ying, Meirong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321125/
https://www.ncbi.nlm.nih.gov/pubmed/30487432
http://dx.doi.org/10.3390/molecules23123117

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