A Review on Liquid Chromatography-Tandem Mass Spectrometry Methods for Rapid Quantification of Oncology Drugs

In the last decade, the tremendous improvement in the sensitivity and also affordability of liquid chromatography-tandem mass spectrometry (LC-MS/MS) has revolutionized its application in pharmaceutical analysis, resulting in widespread employment of LC-MS/MS in determining pharmaceutical compounds,...

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Autores principales: Wong, Andrea Li-Ann, Xiang, Xiaoqiang, Ong, Pei Shi, Mitchell, Ee Qin Ying, Syn, Nicholas, Wee, Ian, Kumar, Alan Prem, Yong, Wei Peng, Sethi, Gautam, Goh, Boon Cher, Ho, Paul Chi-Lui, Wang, Lingzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321130/
https://www.ncbi.nlm.nih.gov/pubmed/30413076
http://dx.doi.org/10.3390/pharmaceutics10040221
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author Wong, Andrea Li-Ann
Xiang, Xiaoqiang
Ong, Pei Shi
Mitchell, Ee Qin Ying
Syn, Nicholas
Wee, Ian
Kumar, Alan Prem
Yong, Wei Peng
Sethi, Gautam
Goh, Boon Cher
Ho, Paul Chi-Lui
Wang, Lingzhi
author_facet Wong, Andrea Li-Ann
Xiang, Xiaoqiang
Ong, Pei Shi
Mitchell, Ee Qin Ying
Syn, Nicholas
Wee, Ian
Kumar, Alan Prem
Yong, Wei Peng
Sethi, Gautam
Goh, Boon Cher
Ho, Paul Chi-Lui
Wang, Lingzhi
author_sort Wong, Andrea Li-Ann
collection PubMed
description In the last decade, the tremendous improvement in the sensitivity and also affordability of liquid chromatography-tandem mass spectrometry (LC-MS/MS) has revolutionized its application in pharmaceutical analysis, resulting in widespread employment of LC-MS/MS in determining pharmaceutical compounds, including anticancer drugs in pharmaceutical research and also industries. Currently, LC-MS/MS has been widely used to quantify small molecule oncology drugs in various biological matrices to support preclinical and clinical pharmacokinetic studies in R&D of oncology drugs. This mini-review article will describe the state-of-the-art LC-MS/MS and its application in rapid quantification of small molecule anticancer drugs. In addition, efforts have also been made in this review to address several key aspects in the development of rapid LC-MS/MS methods, including sample preparation, chromatographic separation, and matrix effect evaluation.
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spelling pubmed-63211302019-01-11 A Review on Liquid Chromatography-Tandem Mass Spectrometry Methods for Rapid Quantification of Oncology Drugs Wong, Andrea Li-Ann Xiang, Xiaoqiang Ong, Pei Shi Mitchell, Ee Qin Ying Syn, Nicholas Wee, Ian Kumar, Alan Prem Yong, Wei Peng Sethi, Gautam Goh, Boon Cher Ho, Paul Chi-Lui Wang, Lingzhi Pharmaceutics Review In the last decade, the tremendous improvement in the sensitivity and also affordability of liquid chromatography-tandem mass spectrometry (LC-MS/MS) has revolutionized its application in pharmaceutical analysis, resulting in widespread employment of LC-MS/MS in determining pharmaceutical compounds, including anticancer drugs in pharmaceutical research and also industries. Currently, LC-MS/MS has been widely used to quantify small molecule oncology drugs in various biological matrices to support preclinical and clinical pharmacokinetic studies in R&D of oncology drugs. This mini-review article will describe the state-of-the-art LC-MS/MS and its application in rapid quantification of small molecule anticancer drugs. In addition, efforts have also been made in this review to address several key aspects in the development of rapid LC-MS/MS methods, including sample preparation, chromatographic separation, and matrix effect evaluation. MDPI 2018-11-08 /pmc/articles/PMC6321130/ /pubmed/30413076 http://dx.doi.org/10.3390/pharmaceutics10040221 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wong, Andrea Li-Ann
Xiang, Xiaoqiang
Ong, Pei Shi
Mitchell, Ee Qin Ying
Syn, Nicholas
Wee, Ian
Kumar, Alan Prem
Yong, Wei Peng
Sethi, Gautam
Goh, Boon Cher
Ho, Paul Chi-Lui
Wang, Lingzhi
A Review on Liquid Chromatography-Tandem Mass Spectrometry Methods for Rapid Quantification of Oncology Drugs
title A Review on Liquid Chromatography-Tandem Mass Spectrometry Methods for Rapid Quantification of Oncology Drugs
title_full A Review on Liquid Chromatography-Tandem Mass Spectrometry Methods for Rapid Quantification of Oncology Drugs
title_fullStr A Review on Liquid Chromatography-Tandem Mass Spectrometry Methods for Rapid Quantification of Oncology Drugs
title_full_unstemmed A Review on Liquid Chromatography-Tandem Mass Spectrometry Methods for Rapid Quantification of Oncology Drugs
title_short A Review on Liquid Chromatography-Tandem Mass Spectrometry Methods for Rapid Quantification of Oncology Drugs
title_sort review on liquid chromatography-tandem mass spectrometry methods for rapid quantification of oncology drugs
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321130/
https://www.ncbi.nlm.nih.gov/pubmed/30413076
http://dx.doi.org/10.3390/pharmaceutics10040221
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