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Application of Real-Time Cell Electronic Analysis System in Modern Pharmaceutical Evaluation and Analysis

Objective: We summarized the progress of the xCELLigence real-time cell analysis (RTCA) technology application in recent years for the sake of enriching and developing the application of RTCA in the field of Chinese medicine. Background: The RTCA system is an established electronic cellular biosenso...

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Autores principales: Yan, Guojun, Du, Qian, Wei, Xuchao, Miozzi, Jackelyn, Kang, Chen, Wang, Jinnv, Han, Xinxin, Pan, Jinhuo, Xie, Hui, Chen, Jun, Zhang, Weihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321149/
https://www.ncbi.nlm.nih.gov/pubmed/30544947
http://dx.doi.org/10.3390/molecules23123280
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author Yan, Guojun
Du, Qian
Wei, Xuchao
Miozzi, Jackelyn
Kang, Chen
Wang, Jinnv
Han, Xinxin
Pan, Jinhuo
Xie, Hui
Chen, Jun
Zhang, Weihua
author_facet Yan, Guojun
Du, Qian
Wei, Xuchao
Miozzi, Jackelyn
Kang, Chen
Wang, Jinnv
Han, Xinxin
Pan, Jinhuo
Xie, Hui
Chen, Jun
Zhang, Weihua
author_sort Yan, Guojun
collection PubMed
description Objective: We summarized the progress of the xCELLigence real-time cell analysis (RTCA) technology application in recent years for the sake of enriching and developing the application of RTCA in the field of Chinese medicine. Background: The RTCA system is an established electronic cellular biosensor. This system uses micro-electronic biosensor technology that is confirmed for real-time, label-free, dynamic and non-offensive monitoring of cell viability, migration, growth, spreading, and proliferation. Methods: We summarized the relevant experiments and literature of RTCA technology from the principles, characteristics, applications, especially from the latest application progress. Results and conclusion: RTCA is attracting more and more attention. Now it plays an important role in drug screening, toxicology, Chinese herbal medicine and so on. It has wide application prospects in the area of modern pharmaceutical evaluation and analysis.
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spelling pubmed-63211492019-01-14 Application of Real-Time Cell Electronic Analysis System in Modern Pharmaceutical Evaluation and Analysis Yan, Guojun Du, Qian Wei, Xuchao Miozzi, Jackelyn Kang, Chen Wang, Jinnv Han, Xinxin Pan, Jinhuo Xie, Hui Chen, Jun Zhang, Weihua Molecules Review Objective: We summarized the progress of the xCELLigence real-time cell analysis (RTCA) technology application in recent years for the sake of enriching and developing the application of RTCA in the field of Chinese medicine. Background: The RTCA system is an established electronic cellular biosensor. This system uses micro-electronic biosensor technology that is confirmed for real-time, label-free, dynamic and non-offensive monitoring of cell viability, migration, growth, spreading, and proliferation. Methods: We summarized the relevant experiments and literature of RTCA technology from the principles, characteristics, applications, especially from the latest application progress. Results and conclusion: RTCA is attracting more and more attention. Now it plays an important role in drug screening, toxicology, Chinese herbal medicine and so on. It has wide application prospects in the area of modern pharmaceutical evaluation and analysis. MDPI 2018-12-11 /pmc/articles/PMC6321149/ /pubmed/30544947 http://dx.doi.org/10.3390/molecules23123280 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yan, Guojun
Du, Qian
Wei, Xuchao
Miozzi, Jackelyn
Kang, Chen
Wang, Jinnv
Han, Xinxin
Pan, Jinhuo
Xie, Hui
Chen, Jun
Zhang, Weihua
Application of Real-Time Cell Electronic Analysis System in Modern Pharmaceutical Evaluation and Analysis
title Application of Real-Time Cell Electronic Analysis System in Modern Pharmaceutical Evaluation and Analysis
title_full Application of Real-Time Cell Electronic Analysis System in Modern Pharmaceutical Evaluation and Analysis
title_fullStr Application of Real-Time Cell Electronic Analysis System in Modern Pharmaceutical Evaluation and Analysis
title_full_unstemmed Application of Real-Time Cell Electronic Analysis System in Modern Pharmaceutical Evaluation and Analysis
title_short Application of Real-Time Cell Electronic Analysis System in Modern Pharmaceutical Evaluation and Analysis
title_sort application of real-time cell electronic analysis system in modern pharmaceutical evaluation and analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321149/
https://www.ncbi.nlm.nih.gov/pubmed/30544947
http://dx.doi.org/10.3390/molecules23123280
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