Cargando…
Solid Lipid Nanoparticles: Emerging Colloidal Nano Drug Delivery Systems
Solid lipid nanoparticles (SLNs) are nanocarriers developed as substitute colloidal drug delivery systems parallel to liposomes, lipid emulsions, polymeric nanoparticles, and so forth. Owing to their unique size dependent properties and ability to incorporate drugs, SLNs present an opportunity to bu...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321253/ https://www.ncbi.nlm.nih.gov/pubmed/30340327 http://dx.doi.org/10.3390/pharmaceutics10040191 |
_version_ | 1783385397901918208 |
---|---|
author | Mishra, Vijay Bansal, Kuldeep K. Verma, Asit Yadav, Nishika Thakur, Sourav Sudhakar, Kalvatala Rosenholm, Jessica M. |
author_facet | Mishra, Vijay Bansal, Kuldeep K. Verma, Asit Yadav, Nishika Thakur, Sourav Sudhakar, Kalvatala Rosenholm, Jessica M. |
author_sort | Mishra, Vijay |
collection | PubMed |
description | Solid lipid nanoparticles (SLNs) are nanocarriers developed as substitute colloidal drug delivery systems parallel to liposomes, lipid emulsions, polymeric nanoparticles, and so forth. Owing to their unique size dependent properties and ability to incorporate drugs, SLNs present an opportunity to build up new therapeutic prototypes for drug delivery and targeting. SLNs hold great potential for attaining the goal of targeted and controlled drug delivery, which currently draws the interest of researchers worldwide. The present review sheds light on different aspects of SLNs including fabrication and characterization techniques, formulation variables, routes of administration, surface modifications, toxicity, and biomedical applications. |
format | Online Article Text |
id | pubmed-6321253 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63212532019-01-11 Solid Lipid Nanoparticles: Emerging Colloidal Nano Drug Delivery Systems Mishra, Vijay Bansal, Kuldeep K. Verma, Asit Yadav, Nishika Thakur, Sourav Sudhakar, Kalvatala Rosenholm, Jessica M. Pharmaceutics Review Solid lipid nanoparticles (SLNs) are nanocarriers developed as substitute colloidal drug delivery systems parallel to liposomes, lipid emulsions, polymeric nanoparticles, and so forth. Owing to their unique size dependent properties and ability to incorporate drugs, SLNs present an opportunity to build up new therapeutic prototypes for drug delivery and targeting. SLNs hold great potential for attaining the goal of targeted and controlled drug delivery, which currently draws the interest of researchers worldwide. The present review sheds light on different aspects of SLNs including fabrication and characterization techniques, formulation variables, routes of administration, surface modifications, toxicity, and biomedical applications. MDPI 2018-10-18 /pmc/articles/PMC6321253/ /pubmed/30340327 http://dx.doi.org/10.3390/pharmaceutics10040191 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mishra, Vijay Bansal, Kuldeep K. Verma, Asit Yadav, Nishika Thakur, Sourav Sudhakar, Kalvatala Rosenholm, Jessica M. Solid Lipid Nanoparticles: Emerging Colloidal Nano Drug Delivery Systems |
title | Solid Lipid Nanoparticles: Emerging Colloidal Nano Drug Delivery Systems |
title_full | Solid Lipid Nanoparticles: Emerging Colloidal Nano Drug Delivery Systems |
title_fullStr | Solid Lipid Nanoparticles: Emerging Colloidal Nano Drug Delivery Systems |
title_full_unstemmed | Solid Lipid Nanoparticles: Emerging Colloidal Nano Drug Delivery Systems |
title_short | Solid Lipid Nanoparticles: Emerging Colloidal Nano Drug Delivery Systems |
title_sort | solid lipid nanoparticles: emerging colloidal nano drug delivery systems |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321253/ https://www.ncbi.nlm.nih.gov/pubmed/30340327 http://dx.doi.org/10.3390/pharmaceutics10040191 |
work_keys_str_mv | AT mishravijay solidlipidnanoparticlesemergingcolloidalnanodrugdeliverysystems AT bansalkuldeepk solidlipidnanoparticlesemergingcolloidalnanodrugdeliverysystems AT vermaasit solidlipidnanoparticlesemergingcolloidalnanodrugdeliverysystems AT yadavnishika solidlipidnanoparticlesemergingcolloidalnanodrugdeliverysystems AT thakursourav solidlipidnanoparticlesemergingcolloidalnanodrugdeliverysystems AT sudhakarkalvatala solidlipidnanoparticlesemergingcolloidalnanodrugdeliverysystems AT rosenholmjessicam solidlipidnanoparticlesemergingcolloidalnanodrugdeliverysystems |