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Solid Lipid Nanoparticles: Emerging Colloidal Nano Drug Delivery Systems

Solid lipid nanoparticles (SLNs) are nanocarriers developed as substitute colloidal drug delivery systems parallel to liposomes, lipid emulsions, polymeric nanoparticles, and so forth. Owing to their unique size dependent properties and ability to incorporate drugs, SLNs present an opportunity to bu...

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Detalles Bibliográficos
Autores principales: Mishra, Vijay, Bansal, Kuldeep K., Verma, Asit, Yadav, Nishika, Thakur, Sourav, Sudhakar, Kalvatala, Rosenholm, Jessica M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321253/
https://www.ncbi.nlm.nih.gov/pubmed/30340327
http://dx.doi.org/10.3390/pharmaceutics10040191
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author Mishra, Vijay
Bansal, Kuldeep K.
Verma, Asit
Yadav, Nishika
Thakur, Sourav
Sudhakar, Kalvatala
Rosenholm, Jessica M.
author_facet Mishra, Vijay
Bansal, Kuldeep K.
Verma, Asit
Yadav, Nishika
Thakur, Sourav
Sudhakar, Kalvatala
Rosenholm, Jessica M.
author_sort Mishra, Vijay
collection PubMed
description Solid lipid nanoparticles (SLNs) are nanocarriers developed as substitute colloidal drug delivery systems parallel to liposomes, lipid emulsions, polymeric nanoparticles, and so forth. Owing to their unique size dependent properties and ability to incorporate drugs, SLNs present an opportunity to build up new therapeutic prototypes for drug delivery and targeting. SLNs hold great potential for attaining the goal of targeted and controlled drug delivery, which currently draws the interest of researchers worldwide. The present review sheds light on different aspects of SLNs including fabrication and characterization techniques, formulation variables, routes of administration, surface modifications, toxicity, and biomedical applications.
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spelling pubmed-63212532019-01-11 Solid Lipid Nanoparticles: Emerging Colloidal Nano Drug Delivery Systems Mishra, Vijay Bansal, Kuldeep K. Verma, Asit Yadav, Nishika Thakur, Sourav Sudhakar, Kalvatala Rosenholm, Jessica M. Pharmaceutics Review Solid lipid nanoparticles (SLNs) are nanocarriers developed as substitute colloidal drug delivery systems parallel to liposomes, lipid emulsions, polymeric nanoparticles, and so forth. Owing to their unique size dependent properties and ability to incorporate drugs, SLNs present an opportunity to build up new therapeutic prototypes for drug delivery and targeting. SLNs hold great potential for attaining the goal of targeted and controlled drug delivery, which currently draws the interest of researchers worldwide. The present review sheds light on different aspects of SLNs including fabrication and characterization techniques, formulation variables, routes of administration, surface modifications, toxicity, and biomedical applications. MDPI 2018-10-18 /pmc/articles/PMC6321253/ /pubmed/30340327 http://dx.doi.org/10.3390/pharmaceutics10040191 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mishra, Vijay
Bansal, Kuldeep K.
Verma, Asit
Yadav, Nishika
Thakur, Sourav
Sudhakar, Kalvatala
Rosenholm, Jessica M.
Solid Lipid Nanoparticles: Emerging Colloidal Nano Drug Delivery Systems
title Solid Lipid Nanoparticles: Emerging Colloidal Nano Drug Delivery Systems
title_full Solid Lipid Nanoparticles: Emerging Colloidal Nano Drug Delivery Systems
title_fullStr Solid Lipid Nanoparticles: Emerging Colloidal Nano Drug Delivery Systems
title_full_unstemmed Solid Lipid Nanoparticles: Emerging Colloidal Nano Drug Delivery Systems
title_short Solid Lipid Nanoparticles: Emerging Colloidal Nano Drug Delivery Systems
title_sort solid lipid nanoparticles: emerging colloidal nano drug delivery systems
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321253/
https://www.ncbi.nlm.nih.gov/pubmed/30340327
http://dx.doi.org/10.3390/pharmaceutics10040191
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