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PI3Kinases in Diabetes Mellitus and Its Related Complications

Recent studies have shown that phosphoinositide 3-kinases (PI3Ks) have become the target of many pharmacological treatments, both in clinical trials and in clinical practice. PI3Ks play an important role in glucose regulation, and this suggests their possible involvement in the onset of diabetes mel...

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Autores principales: Maffei, Angelo, Lembo, Giuseppe, Carnevale, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321267/
https://www.ncbi.nlm.nih.gov/pubmed/30567315
http://dx.doi.org/10.3390/ijms19124098
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author Maffei, Angelo
Lembo, Giuseppe
Carnevale, Daniela
author_facet Maffei, Angelo
Lembo, Giuseppe
Carnevale, Daniela
author_sort Maffei, Angelo
collection PubMed
description Recent studies have shown that phosphoinositide 3-kinases (PI3Ks) have become the target of many pharmacological treatments, both in clinical trials and in clinical practice. PI3Ks play an important role in glucose regulation, and this suggests their possible involvement in the onset of diabetes mellitus. In this review, we gather our knowledge regarding the effects of PI3K isoforms on glucose regulation in several organs and on the most clinically-relevant complications of diabetes mellitus, such as cardiomyopathy, vasculopathy, nephropathy, and neurological disease. For instance, PI3K α has been proven to be protective against diabetes-induced heart failure, while PI3K γ inhibition is protective against the disease onset. In vessels, PI3K γ can generate oxidative stress, while PI3K β inhibition is anti-thrombotic. Finally, we describe the role of PI3Ks in Alzheimer’s disease and ADHD, discussing the relevance for diabetic patients. Given the high prevalence of diabetes mellitus, the multiple effects here described should be taken into account for the development and validation of drugs acting on PI3Ks.
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spelling pubmed-63212672019-01-07 PI3Kinases in Diabetes Mellitus and Its Related Complications Maffei, Angelo Lembo, Giuseppe Carnevale, Daniela Int J Mol Sci Review Recent studies have shown that phosphoinositide 3-kinases (PI3Ks) have become the target of many pharmacological treatments, both in clinical trials and in clinical practice. PI3Ks play an important role in glucose regulation, and this suggests their possible involvement in the onset of diabetes mellitus. In this review, we gather our knowledge regarding the effects of PI3K isoforms on glucose regulation in several organs and on the most clinically-relevant complications of diabetes mellitus, such as cardiomyopathy, vasculopathy, nephropathy, and neurological disease. For instance, PI3K α has been proven to be protective against diabetes-induced heart failure, while PI3K γ inhibition is protective against the disease onset. In vessels, PI3K γ can generate oxidative stress, while PI3K β inhibition is anti-thrombotic. Finally, we describe the role of PI3Ks in Alzheimer’s disease and ADHD, discussing the relevance for diabetic patients. Given the high prevalence of diabetes mellitus, the multiple effects here described should be taken into account for the development and validation of drugs acting on PI3Ks. MDPI 2018-12-18 /pmc/articles/PMC6321267/ /pubmed/30567315 http://dx.doi.org/10.3390/ijms19124098 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Maffei, Angelo
Lembo, Giuseppe
Carnevale, Daniela
PI3Kinases in Diabetes Mellitus and Its Related Complications
title PI3Kinases in Diabetes Mellitus and Its Related Complications
title_full PI3Kinases in Diabetes Mellitus and Its Related Complications
title_fullStr PI3Kinases in Diabetes Mellitus and Its Related Complications
title_full_unstemmed PI3Kinases in Diabetes Mellitus and Its Related Complications
title_short PI3Kinases in Diabetes Mellitus and Its Related Complications
title_sort pi3kinases in diabetes mellitus and its related complications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321267/
https://www.ncbi.nlm.nih.gov/pubmed/30567315
http://dx.doi.org/10.3390/ijms19124098
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