Cargando…
PI3Kinases in Diabetes Mellitus and Its Related Complications
Recent studies have shown that phosphoinositide 3-kinases (PI3Ks) have become the target of many pharmacological treatments, both in clinical trials and in clinical practice. PI3Ks play an important role in glucose regulation, and this suggests their possible involvement in the onset of diabetes mel...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321267/ https://www.ncbi.nlm.nih.gov/pubmed/30567315 http://dx.doi.org/10.3390/ijms19124098 |
_version_ | 1783385401213321216 |
---|---|
author | Maffei, Angelo Lembo, Giuseppe Carnevale, Daniela |
author_facet | Maffei, Angelo Lembo, Giuseppe Carnevale, Daniela |
author_sort | Maffei, Angelo |
collection | PubMed |
description | Recent studies have shown that phosphoinositide 3-kinases (PI3Ks) have become the target of many pharmacological treatments, both in clinical trials and in clinical practice. PI3Ks play an important role in glucose regulation, and this suggests their possible involvement in the onset of diabetes mellitus. In this review, we gather our knowledge regarding the effects of PI3K isoforms on glucose regulation in several organs and on the most clinically-relevant complications of diabetes mellitus, such as cardiomyopathy, vasculopathy, nephropathy, and neurological disease. For instance, PI3K α has been proven to be protective against diabetes-induced heart failure, while PI3K γ inhibition is protective against the disease onset. In vessels, PI3K γ can generate oxidative stress, while PI3K β inhibition is anti-thrombotic. Finally, we describe the role of PI3Ks in Alzheimer’s disease and ADHD, discussing the relevance for diabetic patients. Given the high prevalence of diabetes mellitus, the multiple effects here described should be taken into account for the development and validation of drugs acting on PI3Ks. |
format | Online Article Text |
id | pubmed-6321267 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63212672019-01-07 PI3Kinases in Diabetes Mellitus and Its Related Complications Maffei, Angelo Lembo, Giuseppe Carnevale, Daniela Int J Mol Sci Review Recent studies have shown that phosphoinositide 3-kinases (PI3Ks) have become the target of many pharmacological treatments, both in clinical trials and in clinical practice. PI3Ks play an important role in glucose regulation, and this suggests their possible involvement in the onset of diabetes mellitus. In this review, we gather our knowledge regarding the effects of PI3K isoforms on glucose regulation in several organs and on the most clinically-relevant complications of diabetes mellitus, such as cardiomyopathy, vasculopathy, nephropathy, and neurological disease. For instance, PI3K α has been proven to be protective against diabetes-induced heart failure, while PI3K γ inhibition is protective against the disease onset. In vessels, PI3K γ can generate oxidative stress, while PI3K β inhibition is anti-thrombotic. Finally, we describe the role of PI3Ks in Alzheimer’s disease and ADHD, discussing the relevance for diabetic patients. Given the high prevalence of diabetes mellitus, the multiple effects here described should be taken into account for the development and validation of drugs acting on PI3Ks. MDPI 2018-12-18 /pmc/articles/PMC6321267/ /pubmed/30567315 http://dx.doi.org/10.3390/ijms19124098 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Maffei, Angelo Lembo, Giuseppe Carnevale, Daniela PI3Kinases in Diabetes Mellitus and Its Related Complications |
title | PI3Kinases in Diabetes Mellitus and Its Related Complications |
title_full | PI3Kinases in Diabetes Mellitus and Its Related Complications |
title_fullStr | PI3Kinases in Diabetes Mellitus and Its Related Complications |
title_full_unstemmed | PI3Kinases in Diabetes Mellitus and Its Related Complications |
title_short | PI3Kinases in Diabetes Mellitus and Its Related Complications |
title_sort | pi3kinases in diabetes mellitus and its related complications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321267/ https://www.ncbi.nlm.nih.gov/pubmed/30567315 http://dx.doi.org/10.3390/ijms19124098 |
work_keys_str_mv | AT maffeiangelo pi3kinasesindiabetesmellitusanditsrelatedcomplications AT lembogiuseppe pi3kinasesindiabetesmellitusanditsrelatedcomplications AT carnevaledaniela pi3kinasesindiabetesmellitusanditsrelatedcomplications |