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The Ambivalent Function of YAP in Apoptosis and Cancer
Yes-associated protein, a core regulator of the Hippo-YAP signaling pathway, plays a vital role in inhibiting apoptosis. Thus, several studies and reviews suggest that yes-associated protein is a good target for treating cancer. Unfortunately, more and more evidence demonstrates that this protein is...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321280/ https://www.ncbi.nlm.nih.gov/pubmed/30486435 http://dx.doi.org/10.3390/ijms19123770 |
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author | Zhang, Xianbin Abdelrahman, Ahmed Vollmar, Brigitte Zechner, Dietmar |
author_facet | Zhang, Xianbin Abdelrahman, Ahmed Vollmar, Brigitte Zechner, Dietmar |
author_sort | Zhang, Xianbin |
collection | PubMed |
description | Yes-associated protein, a core regulator of the Hippo-YAP signaling pathway, plays a vital role in inhibiting apoptosis. Thus, several studies and reviews suggest that yes-associated protein is a good target for treating cancer. Unfortunately, more and more evidence demonstrates that this protein is also an essential contributor of p73-mediated apoptosis. This questions the concept that yes-associated protein is always a good target for developing novel anti-cancer drugs. Thus, the aim of this review was to evaluate the clinical relevance of yes-associated protein for cancer pathophysiology. This review also summarized the molecules, processes and drugs, which regulate Hippo-YAP signaling and discusses their effect on apoptosis. In addition, issues are defined, which should be addressed in the future in order to provide a solid basis for targeting the Hippo-YAP signaling pathway in clinical trials. |
format | Online Article Text |
id | pubmed-6321280 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63212802019-01-07 The Ambivalent Function of YAP in Apoptosis and Cancer Zhang, Xianbin Abdelrahman, Ahmed Vollmar, Brigitte Zechner, Dietmar Int J Mol Sci Review Yes-associated protein, a core regulator of the Hippo-YAP signaling pathway, plays a vital role in inhibiting apoptosis. Thus, several studies and reviews suggest that yes-associated protein is a good target for treating cancer. Unfortunately, more and more evidence demonstrates that this protein is also an essential contributor of p73-mediated apoptosis. This questions the concept that yes-associated protein is always a good target for developing novel anti-cancer drugs. Thus, the aim of this review was to evaluate the clinical relevance of yes-associated protein for cancer pathophysiology. This review also summarized the molecules, processes and drugs, which regulate Hippo-YAP signaling and discusses their effect on apoptosis. In addition, issues are defined, which should be addressed in the future in order to provide a solid basis for targeting the Hippo-YAP signaling pathway in clinical trials. MDPI 2018-11-27 /pmc/articles/PMC6321280/ /pubmed/30486435 http://dx.doi.org/10.3390/ijms19123770 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zhang, Xianbin Abdelrahman, Ahmed Vollmar, Brigitte Zechner, Dietmar The Ambivalent Function of YAP in Apoptosis and Cancer |
title | The Ambivalent Function of YAP in Apoptosis and Cancer |
title_full | The Ambivalent Function of YAP in Apoptosis and Cancer |
title_fullStr | The Ambivalent Function of YAP in Apoptosis and Cancer |
title_full_unstemmed | The Ambivalent Function of YAP in Apoptosis and Cancer |
title_short | The Ambivalent Function of YAP in Apoptosis and Cancer |
title_sort | ambivalent function of yap in apoptosis and cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321280/ https://www.ncbi.nlm.nih.gov/pubmed/30486435 http://dx.doi.org/10.3390/ijms19123770 |
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