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The Ambivalent Function of YAP in Apoptosis and Cancer

Yes-associated protein, a core regulator of the Hippo-YAP signaling pathway, plays a vital role in inhibiting apoptosis. Thus, several studies and reviews suggest that yes-associated protein is a good target for treating cancer. Unfortunately, more and more evidence demonstrates that this protein is...

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Detalles Bibliográficos
Autores principales: Zhang, Xianbin, Abdelrahman, Ahmed, Vollmar, Brigitte, Zechner, Dietmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321280/
https://www.ncbi.nlm.nih.gov/pubmed/30486435
http://dx.doi.org/10.3390/ijms19123770
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author Zhang, Xianbin
Abdelrahman, Ahmed
Vollmar, Brigitte
Zechner, Dietmar
author_facet Zhang, Xianbin
Abdelrahman, Ahmed
Vollmar, Brigitte
Zechner, Dietmar
author_sort Zhang, Xianbin
collection PubMed
description Yes-associated protein, a core regulator of the Hippo-YAP signaling pathway, plays a vital role in inhibiting apoptosis. Thus, several studies and reviews suggest that yes-associated protein is a good target for treating cancer. Unfortunately, more and more evidence demonstrates that this protein is also an essential contributor of p73-mediated apoptosis. This questions the concept that yes-associated protein is always a good target for developing novel anti-cancer drugs. Thus, the aim of this review was to evaluate the clinical relevance of yes-associated protein for cancer pathophysiology. This review also summarized the molecules, processes and drugs, which regulate Hippo-YAP signaling and discusses their effect on apoptosis. In addition, issues are defined, which should be addressed in the future in order to provide a solid basis for targeting the Hippo-YAP signaling pathway in clinical trials.
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spelling pubmed-63212802019-01-07 The Ambivalent Function of YAP in Apoptosis and Cancer Zhang, Xianbin Abdelrahman, Ahmed Vollmar, Brigitte Zechner, Dietmar Int J Mol Sci Review Yes-associated protein, a core regulator of the Hippo-YAP signaling pathway, plays a vital role in inhibiting apoptosis. Thus, several studies and reviews suggest that yes-associated protein is a good target for treating cancer. Unfortunately, more and more evidence demonstrates that this protein is also an essential contributor of p73-mediated apoptosis. This questions the concept that yes-associated protein is always a good target for developing novel anti-cancer drugs. Thus, the aim of this review was to evaluate the clinical relevance of yes-associated protein for cancer pathophysiology. This review also summarized the molecules, processes and drugs, which regulate Hippo-YAP signaling and discusses their effect on apoptosis. In addition, issues are defined, which should be addressed in the future in order to provide a solid basis for targeting the Hippo-YAP signaling pathway in clinical trials. MDPI 2018-11-27 /pmc/articles/PMC6321280/ /pubmed/30486435 http://dx.doi.org/10.3390/ijms19123770 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhang, Xianbin
Abdelrahman, Ahmed
Vollmar, Brigitte
Zechner, Dietmar
The Ambivalent Function of YAP in Apoptosis and Cancer
title The Ambivalent Function of YAP in Apoptosis and Cancer
title_full The Ambivalent Function of YAP in Apoptosis and Cancer
title_fullStr The Ambivalent Function of YAP in Apoptosis and Cancer
title_full_unstemmed The Ambivalent Function of YAP in Apoptosis and Cancer
title_short The Ambivalent Function of YAP in Apoptosis and Cancer
title_sort ambivalent function of yap in apoptosis and cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321280/
https://www.ncbi.nlm.nih.gov/pubmed/30486435
http://dx.doi.org/10.3390/ijms19123770
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