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Design and Properties of Ligand-Conjugated Guanine Oligonucleotides for Recovery of Mutated G-Quadruplexes

The formation of a guanine quadruplex DNA structure (G4) is known to repress the expression of certain cancer-related genes. Consequently, a mutated G4 sequence can affect quadruplex formation and induce cancer progression. In this study, we developed an oligonucleotide derivative consisting of a li...

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Detalles Bibliográficos
Autores principales:	Takahashi, Shuntaro, Chelobanov, Boris, Kim, Ki Tae, Kim, Byeang Hyean, Stetsenko, Dmitry, Sugimoto, Naoki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321378/ https://www.ncbi.nlm.nih.gov/pubmed/30563296 http://dx.doi.org/10.3390/molecules23123228

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