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Molecular Mechanism of Action of RORγt Agonists and Inverse Agonists: Insights from Molecular Dynamics Simulation

As an attractive drug-target, retinoic acid receptor-related orphan receptor-gamma-t (RORγt) has been employed widely to develop clinically relevant small molecular modulators as potent therapy for autoimmune disease and cancer, but its molecular mechanism of action (MOA) remains unclear. In the pre...

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Detalles Bibliográficos
Autores principales: Sun, Nannan, Yuan, Congmin, Ma, Xiaojun, Wang, Yonghui, Gu, Xianfeng, Fu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321388/
https://www.ncbi.nlm.nih.gov/pubmed/30513894
http://dx.doi.org/10.3390/molecules23123181

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