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Mollicellins O–R, Four New Depsidones Isolated from the Endophytic Fungus Chaetomium sp. Eef-10

Four new depsidones, mollicellins O–R (compounds 1–4), along with three known compounds 5–7, were isolated from cultures of the fungus Chaetomium sp. Eef-10, an endophyte isolated from Eucalyptus exserta. The structures of the new compounds were elucidated by analysis of the 1D and 2D NMR and HR-ESI...

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Autores principales: Ouyang, Jinkui, Mao, Ziling, Guo, Hui, Xie, Yunying, Cui, Zehua, Sun, Jian, Wu, Huixiong, Wen, Xiujun, Wang, Jun, Shan, Tijiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321418/
https://www.ncbi.nlm.nih.gov/pubmed/30563178
http://dx.doi.org/10.3390/molecules23123218
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author Ouyang, Jinkui
Mao, Ziling
Guo, Hui
Xie, Yunying
Cui, Zehua
Sun, Jian
Wu, Huixiong
Wen, Xiujun
Wang, Jun
Shan, Tijiang
author_facet Ouyang, Jinkui
Mao, Ziling
Guo, Hui
Xie, Yunying
Cui, Zehua
Sun, Jian
Wu, Huixiong
Wen, Xiujun
Wang, Jun
Shan, Tijiang
author_sort Ouyang, Jinkui
collection PubMed
description Four new depsidones, mollicellins O–R (compounds 1–4), along with three known compounds 5–7, were isolated from cultures of the fungus Chaetomium sp. Eef-10, an endophyte isolated from Eucalyptus exserta. The structures of the new compounds were elucidated by analysis of the 1D and 2D NMR and HR-ESI-MS spectra. The known compounds were identified by comparison of their spectral data with published values. Compounds 1–7 were evaluated for antibacterial activities against Staphylococcus aureus (sensitive and resistant strains), Escherichia coli, Agrobacterium tumefaciens, Salmonella typhimurium, Pseudomonas lachrymans, Ralstonia solanacearum, Xanthomonas vesicatoria and cytotoxic activities against two human cancer cell lines (HepG2 and Hela). Mollicellin H (6) displayed best antibacterial activity, with IC(50) values of 5.14 µg/mL against S. aureus ATCC29213 and 6.21 µg/mL against S. aureus N50, MRSA, respectively. Mollicellin O (1) and mollicellin I (7) also exhibited antibacterial activities against S. aureus ATCC29213 and S. aureus N50. Mollicellin G (5) was active against both two human cancer cell lines, with IC(50) values of 19.64 and 13.97 µg/mL while compounds 6 and 7 only showed cytotoxic activity against one cell line. In addition, mollicellin O (1) showed antioxidant activity based on DPPH radical scavenging, with an IC(50) value of 71.92 µg/mL.
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spelling pubmed-63214182019-01-14 Mollicellins O–R, Four New Depsidones Isolated from the Endophytic Fungus Chaetomium sp. Eef-10 Ouyang, Jinkui Mao, Ziling Guo, Hui Xie, Yunying Cui, Zehua Sun, Jian Wu, Huixiong Wen, Xiujun Wang, Jun Shan, Tijiang Molecules Article Four new depsidones, mollicellins O–R (compounds 1–4), along with three known compounds 5–7, were isolated from cultures of the fungus Chaetomium sp. Eef-10, an endophyte isolated from Eucalyptus exserta. The structures of the new compounds were elucidated by analysis of the 1D and 2D NMR and HR-ESI-MS spectra. The known compounds were identified by comparison of their spectral data with published values. Compounds 1–7 were evaluated for antibacterial activities against Staphylococcus aureus (sensitive and resistant strains), Escherichia coli, Agrobacterium tumefaciens, Salmonella typhimurium, Pseudomonas lachrymans, Ralstonia solanacearum, Xanthomonas vesicatoria and cytotoxic activities against two human cancer cell lines (HepG2 and Hela). Mollicellin H (6) displayed best antibacterial activity, with IC(50) values of 5.14 µg/mL against S. aureus ATCC29213 and 6.21 µg/mL against S. aureus N50, MRSA, respectively. Mollicellin O (1) and mollicellin I (7) also exhibited antibacterial activities against S. aureus ATCC29213 and S. aureus N50. Mollicellin G (5) was active against both two human cancer cell lines, with IC(50) values of 19.64 and 13.97 µg/mL while compounds 6 and 7 only showed cytotoxic activity against one cell line. In addition, mollicellin O (1) showed antioxidant activity based on DPPH radical scavenging, with an IC(50) value of 71.92 µg/mL. MDPI 2018-12-05 /pmc/articles/PMC6321418/ /pubmed/30563178 http://dx.doi.org/10.3390/molecules23123218 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ouyang, Jinkui
Mao, Ziling
Guo, Hui
Xie, Yunying
Cui, Zehua
Sun, Jian
Wu, Huixiong
Wen, Xiujun
Wang, Jun
Shan, Tijiang
Mollicellins O–R, Four New Depsidones Isolated from the Endophytic Fungus Chaetomium sp. Eef-10
title Mollicellins O–R, Four New Depsidones Isolated from the Endophytic Fungus Chaetomium sp. Eef-10
title_full Mollicellins O–R, Four New Depsidones Isolated from the Endophytic Fungus Chaetomium sp. Eef-10
title_fullStr Mollicellins O–R, Four New Depsidones Isolated from the Endophytic Fungus Chaetomium sp. Eef-10
title_full_unstemmed Mollicellins O–R, Four New Depsidones Isolated from the Endophytic Fungus Chaetomium sp. Eef-10
title_short Mollicellins O–R, Four New Depsidones Isolated from the Endophytic Fungus Chaetomium sp. Eef-10
title_sort mollicellins o–r, four new depsidones isolated from the endophytic fungus chaetomium sp. eef-10
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321418/
https://www.ncbi.nlm.nih.gov/pubmed/30563178
http://dx.doi.org/10.3390/molecules23123218
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