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Long Non-Coding RNAs as Mediators of Tumor Microenvironment and Liver Cancer Cell Communication

The tumor microenvironment is an important concept that defines cancer development not only through tumor cells themselves but also the surrounding cellular and non-cellular components, including stromal cells, blood vessels, infiltrating inflammatory cells, cancer stem cells (CSC), cytokines, and g...

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Autores principales: Lin, Yang-Hsiang, Wu, Meng-Han, Yeh, Chau-Ting, Lin, Kwang-Huei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321423/
https://www.ncbi.nlm.nih.gov/pubmed/30477236
http://dx.doi.org/10.3390/ijms19123742
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author Lin, Yang-Hsiang
Wu, Meng-Han
Yeh, Chau-Ting
Lin, Kwang-Huei
author_facet Lin, Yang-Hsiang
Wu, Meng-Han
Yeh, Chau-Ting
Lin, Kwang-Huei
author_sort Lin, Yang-Hsiang
collection PubMed
description The tumor microenvironment is an important concept that defines cancer development not only through tumor cells themselves but also the surrounding cellular and non-cellular components, including stromal cells, blood vessels, infiltrating inflammatory cells, cancer stem cells (CSC), cytokines, and growth factors, which act in concert to promote tumor cell survival and metastasis. Hepatocellular carcinoma (HCC) is one of the most common and aggressive human malignancies worldwide. Poor prognosis is largely attributable to the high rate of tumor metastasis, highlighting the importance of identifying patients at risk in advance and developing novel therapeutic targets to facilitate effective intervention. Long non-coding RNAs (lncRNA) are a class of non-protein coding transcripts longer than 200 nucleotides frequently dysregulated in various cancer types, which have multiple functions in widespread biological processes, including proliferation, apoptosis, metastasis, and metabolism. lncRNAs are involved in regulation of the tumor microenvironment and reciprocal signaling between cancer cells. Targeting of components of the tumor microenvironment or cancer cells has become a considerable focus of therapeutic research and establishing the effects of different lncRNAs on this network should aid in the development of effective treatment strategies. The current review provides a summary of the essential properties and functional roles of known lncRNAs associated with the tumor microenvironment in HCC.
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spelling pubmed-63214232019-01-07 Long Non-Coding RNAs as Mediators of Tumor Microenvironment and Liver Cancer Cell Communication Lin, Yang-Hsiang Wu, Meng-Han Yeh, Chau-Ting Lin, Kwang-Huei Int J Mol Sci Review The tumor microenvironment is an important concept that defines cancer development not only through tumor cells themselves but also the surrounding cellular and non-cellular components, including stromal cells, blood vessels, infiltrating inflammatory cells, cancer stem cells (CSC), cytokines, and growth factors, which act in concert to promote tumor cell survival and metastasis. Hepatocellular carcinoma (HCC) is one of the most common and aggressive human malignancies worldwide. Poor prognosis is largely attributable to the high rate of tumor metastasis, highlighting the importance of identifying patients at risk in advance and developing novel therapeutic targets to facilitate effective intervention. Long non-coding RNAs (lncRNA) are a class of non-protein coding transcripts longer than 200 nucleotides frequently dysregulated in various cancer types, which have multiple functions in widespread biological processes, including proliferation, apoptosis, metastasis, and metabolism. lncRNAs are involved in regulation of the tumor microenvironment and reciprocal signaling between cancer cells. Targeting of components of the tumor microenvironment or cancer cells has become a considerable focus of therapeutic research and establishing the effects of different lncRNAs on this network should aid in the development of effective treatment strategies. The current review provides a summary of the essential properties and functional roles of known lncRNAs associated with the tumor microenvironment in HCC. MDPI 2018-11-24 /pmc/articles/PMC6321423/ /pubmed/30477236 http://dx.doi.org/10.3390/ijms19123742 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lin, Yang-Hsiang
Wu, Meng-Han
Yeh, Chau-Ting
Lin, Kwang-Huei
Long Non-Coding RNAs as Mediators of Tumor Microenvironment and Liver Cancer Cell Communication
title Long Non-Coding RNAs as Mediators of Tumor Microenvironment and Liver Cancer Cell Communication
title_full Long Non-Coding RNAs as Mediators of Tumor Microenvironment and Liver Cancer Cell Communication
title_fullStr Long Non-Coding RNAs as Mediators of Tumor Microenvironment and Liver Cancer Cell Communication
title_full_unstemmed Long Non-Coding RNAs as Mediators of Tumor Microenvironment and Liver Cancer Cell Communication
title_short Long Non-Coding RNAs as Mediators of Tumor Microenvironment and Liver Cancer Cell Communication
title_sort long non-coding rnas as mediators of tumor microenvironment and liver cancer cell communication
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321423/
https://www.ncbi.nlm.nih.gov/pubmed/30477236
http://dx.doi.org/10.3390/ijms19123742
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