Cargando…

Cloning, Characterization and Anion Inhibition Studies of a β-Carbonic Anhydrase from the Pathogenic Protozoan Entamoeba histolytica

We report the cloning and catalytic activity of a β-carbonic anhydrase (CA, EC 4.2.1.1), isolated from the pathogenic protozoan Entamoeba histolytica, EhiCA. This enzyme has a high catalytic activity for the physiologic CO(2) hydration reaction, with a k(cat) of 6.7 × 10(5) s(−1) and a k(cat)/K(m) o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Haapanen, Susanna, Bua, Silvia, Kuuslahti, Marianne, Parkkila, Seppo, Supuran, Claudiu T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321543/ https://www.ncbi.nlm.nih.gov/pubmed/30486513 http://dx.doi.org/10.3390/molecules23123112

Ejemplares similares

Activation Studies of the β-Carbonic Anhydrase from the Pathogenic Protozoan Entamoeba histolytica with Amino Acids and Amines
por: Bua, Silvia, et al.
Publicado: (2019)

Sulfonamide Inhibition Studies of a New β-Carbonic Anhydrase from the Pathogenic Protozoan Entamoeba histolytica
por: Bua, Silvia, et al.
Publicado: (2018)

Anion inhibition studies of a beta carbonic anhydrase from the malaria mosquito Anopheles gambiae
por: Vullo, Daniela, et al.
Publicado: (2018)

Sulphonamide inhibition profile of Staphylococcus aureus β-carbonic anhydrase
por: Urbanski, Linda J., et al.
Publicado: (2020)

Inhibition studies of the protozoan α-carbonic anhydrase from Trypanosoma cruzi with phenols
por: Bonardi, Alessandro, et al.
Publicado: (2022)

Cloning, characterization, and inhibition of the novel β-carbonic anhydrase from parasitic blood fluke, Schistosoma mansoni
por: Haapanen, Susanna, et al.
Publicado: (2023)

Activation of the β-carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with amines and amino acids
por: Angeli, Andrea, et al.
Publicado: (2021)

Inhibition of the β-carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with sulphonamides
por: Urbański, Linda J., et al.
Publicado: (2020)

Biochemical and structural characterisation of a protozoan beta-carbonic anhydrase from Trichomonas vaginalis
por: Urbański, Linda J., et al.
Publicado: (2020)

Cloning, purification, kinetic and anion inhibition studies of a recombinant β-carbonic anhydrase from the Atlantic salmon parasite platyhelminth Gyrodactylus salaris
por: Aspatwar, Ashok, et al.
Publicado: (2022)

The production and biochemical characterization of α-carbonic anhydrase from Lactobacillus rhamnosus GG
por: Urbański, Linda J., et al.
Publicado: (2022)

Ascaris lumbricoides β carbonic anhydrase: a potential target enzyme for treatment of ascariasis
por: Zolfaghari Emameh, Reza, et al.
Publicado: (2015)

An anion and small molecule inhibition study of the β-carbonic anhydrase from Staphylococcus aureus
por: Urbanski, Linda J., et al.
Publicado: (2021)

Biochemical and structural characterization of beta-carbonic anhydrase from the parasite Trichomonas vaginalis
por: Urbański, Linda J., et al.
Publicado: (2021)

An Update on the Metabolic Roles of Carbonic Anhydrases in the Model Alga Chlamydomonas reinhardtii
por: Aspatwar, Ashok, et al.
Publicado: (2018)

Toxicity evaluation of sulfamides and coumarins that efficiently inhibit human carbonic anhydrases
por: Aspatwar, Ashok, et al.
Publicado: (2020)

β carbonic anhydrase is required for female fertility in Drosophila melanogaster
por: Syrjänen, Leo, et al.
Publicado: (2015)

Innovative molecular diagnosis of T richinella species based on β‐carbonic anhydrase genomic sequence
por: Zolfaghari Emameh, Reza, et al.
Publicado: (2015)

Assessment of databases to determine the validity of β- and γ-carbonic anhydrase sequences from vertebrates
por: Zolfaghari Emameh, Reza, et al.
Publicado: (2020)

Bioinformatic analysis of beta carbonic anhydrase sequences from protozoans and metazoans
por: Zolfaghari Emameh, Reza, et al.
Publicado: (2014)

Mitochondrial carbonic anhydrase VA and VB: properties and roles in health and disease
por: Aspatwar, Ashok, et al.
Publicado: (2022)

Trichostatin A effects on gene expression in the protozoan parasite Entamoeba histolytica
por: Ehrenkaufer, Gretchen M, et al.
Publicado: (2007)

Carbonic Anhydrase Inhibitors as Novel Drugs against Mycobacterial β-Carbonic Anhydrases: An Update on In Vitro and In Vivo Studies
por: Aspatwar, Ashok, et al.
Publicado: (2018)

Activation studies with amino acids and amines of a β-carbonic anhydrase from Mammaliicoccus (Staphylococcus) sciuri previously annotated as Staphylococcus aureus (SauBCA) carbonic anhydrase
por: Angeli, Andrea, et al.
Publicado: (2022)

Role of the Gut Microbiota of Children in Diarrhea Due to the Protozoan Parasite Entamoeba histolytica
por: Gilchrist, Carol A., et al.
Publicado: (2016)

Postsplicing-Derived Full-Length Intron Circles in the Protozoan Parasite Entamoeba histolytica
por: Mendoza-Figueroa, María S., et al.
Publicado: (2018)

Identification of the phospholipid lysobisphosphatidic acid in the protozoan Entamoeba histolytica: An active molecule in endocytosis
por: Castellanos-Castro, Silvia, et al.
Publicado: (2015)

The NF-κB Pathway: Modulation by Entamoeba histolytica and Other Protozoan Parasites
por: Chadha, Attinder, et al.
Publicado: (2021)

Gasdermins in Innate Host Defense Against Entamoeba histolytica and Other Protozoan Parasites
por: Wang, Shanshan, et al.
Publicado: (2022)

Horizontal transfer of β-carbonic anhydrase genes from prokaryotes to protozoans, insects, and nematodes
por: Zolfaghari Emameh, Reza, et al.
Publicado: (2016)

Hypoxia-Activated Prodrug Derivatives of Carbonic Anhydrase Inhibitors in Benzenesulfonamide Series: Synthesis and Biological Evaluation
por: Anduran, Emilie, et al.
Publicado: (2020)

Comparative Pathobiology of the Intestinal Protozoan Parasites Giardia lamblia, Entamoeba histolytica, and Cryptosporidium parvum
por: Hemphill, Andrew, et al.
Publicado: (2019)

PTEN differentially regulates endocytosis, migration, and proliferation in the enteric protozoan parasite Entamoeba histolytica
por: Kadri, Samia, et al.
Publicado: (2022)

Overexpression of Specific Cysteine Peptidases Confers Pathogenicity to a Nonpathogenic Entamoeba histolytica Clone
por: Matthiesen, Jenny, et al.
Publicado: (2013)

Roles of Carbonic Anhydrases and Carbonic Anhydrase Related Proteins in Zebrafish
por: Aspatwar, Ashok, et al.
Publicado: (2022)

Carbonic Anhydrases and Metabolism
por: Supuran, Claudiu T.
Publicado: (2018)

Anion inhibition studies of the α-carbonic anhydrases from Neisseria gonorrhoeae
por: Nocentini, Alessio, et al.
Publicado: (2021)

Mycobacterium tuberculosisβ-Carbonic Anhydrases: Novel Targets for Developing Antituberculosis Drugs
por: Aspatwar, Ashok, et al.
Publicado: (2019)

Dramatic Increase in Glycerol Biosynthesis upon Oxidative Stress in the Anaerobic Protozoan Parasite Entamoeba histolytica
por: Husain, Afzal, et al.
Publicado: (2012)

Pathogenicity and virulence of Entamoeba histolytica, the agent of amoebiasis
por: Guillén, Nancy
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ijjlvl93jqv4qme08l0e7r2c1d