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Regenerative Models for the Integration and Regeneration of Head Skeletal Tissues

Disease of, or trauma to, the human jaw account for thousands of reconstructive surgeries performed every year. One of the most popular and successful treatment options in this context involves the transplantation of bone tissue from a different anatomical region into the affected jaw. Although, thi...

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Detalles Bibliográficos
Autores principales: Vieira, Warren A., McCusker, Catherine D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321600/
https://www.ncbi.nlm.nih.gov/pubmed/30486286
http://dx.doi.org/10.3390/ijms19123752
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author Vieira, Warren A.
McCusker, Catherine D.
author_facet Vieira, Warren A.
McCusker, Catherine D.
author_sort Vieira, Warren A.
collection PubMed
description Disease of, or trauma to, the human jaw account for thousands of reconstructive surgeries performed every year. One of the most popular and successful treatment options in this context involves the transplantation of bone tissue from a different anatomical region into the affected jaw. Although, this method has been largely successful, the integration of the new bone into the existing bone is often imperfect, and the integration of the host soft tissues with the transplanted bone can be inconsistent, resulting in impaired function. Unlike humans, several vertebrate species, including fish and amphibians, demonstrate remarkable regenerative capabilities in response to jaw injury. Therefore, with the objective of identifying biological targets to promote and engineer improved outcomes in the context of jaw reconstructive surgery, we explore, compare and contrast the natural mechanisms of endogenous jaw and limb repair and regeneration in regenerative model organisms. We focus on the role of different cell types as they contribute to the regenerating structure; how mature cells acquire plasticity in vivo; the role of positional information in pattern formation and tissue integration, and limitations to endogenous regenerative and repair mechanisms.
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spelling pubmed-63216002019-01-07 Regenerative Models for the Integration and Regeneration of Head Skeletal Tissues Vieira, Warren A. McCusker, Catherine D. Int J Mol Sci Review Disease of, or trauma to, the human jaw account for thousands of reconstructive surgeries performed every year. One of the most popular and successful treatment options in this context involves the transplantation of bone tissue from a different anatomical region into the affected jaw. Although, this method has been largely successful, the integration of the new bone into the existing bone is often imperfect, and the integration of the host soft tissues with the transplanted bone can be inconsistent, resulting in impaired function. Unlike humans, several vertebrate species, including fish and amphibians, demonstrate remarkable regenerative capabilities in response to jaw injury. Therefore, with the objective of identifying biological targets to promote and engineer improved outcomes in the context of jaw reconstructive surgery, we explore, compare and contrast the natural mechanisms of endogenous jaw and limb repair and regeneration in regenerative model organisms. We focus on the role of different cell types as they contribute to the regenerating structure; how mature cells acquire plasticity in vivo; the role of positional information in pattern formation and tissue integration, and limitations to endogenous regenerative and repair mechanisms. MDPI 2018-11-26 /pmc/articles/PMC6321600/ /pubmed/30486286 http://dx.doi.org/10.3390/ijms19123752 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Vieira, Warren A.
McCusker, Catherine D.
Regenerative Models for the Integration and Regeneration of Head Skeletal Tissues
title Regenerative Models for the Integration and Regeneration of Head Skeletal Tissues
title_full Regenerative Models for the Integration and Regeneration of Head Skeletal Tissues
title_fullStr Regenerative Models for the Integration and Regeneration of Head Skeletal Tissues
title_full_unstemmed Regenerative Models for the Integration and Regeneration of Head Skeletal Tissues
title_short Regenerative Models for the Integration and Regeneration of Head Skeletal Tissues
title_sort regenerative models for the integration and regeneration of head skeletal tissues
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321600/
https://www.ncbi.nlm.nih.gov/pubmed/30486286
http://dx.doi.org/10.3390/ijms19123752
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