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Mutations Utilize Dynamic Allostery to Confer Resistance in TEM-1 β-lactamase
β-lactamases are enzymes produced by bacteria to hydrolyze β-lactam antibiotics as a common mechanism of resistance. Evolution in such enzymes has been rendering a wide variety of antibiotics impotent, therefore posing a major threat. Clinical and in vitro studies of evolution in TEM-1 β-lactamase h...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321620/ https://www.ncbi.nlm.nih.gov/pubmed/30501088 http://dx.doi.org/10.3390/ijms19123808 |