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First-in-human study assessing safety, tolerability, and pharmacokinetics of 2-hydroxybenzylamine acetate, a selective dicarbonyl electrophile scavenger, in healthy volunteers
BACKGROUND: 2-Hydroxybenzylamine (2-HOBA) is a selective scavenger of dicarbonyl electrophiles that protects proteins and lipids from being modified by these electrophiles. It is currently being developed for use as a nutritional supplement to help maintain good health and protect against the develo...
Autores principales: | Pitchford, Lisa M., Rathmacher, John A., Fuller, John C., Daniels, J. Scott, Morrison, Ryan D., Akers, Wendall S., Abumrad, Naji N., Amarnath, Venkataraman, Currey, Patricia M., Roberts, L. Jackson, Oates, John A., Boutaud, Olivier |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321651/ https://www.ncbi.nlm.nih.gov/pubmed/30611293 http://dx.doi.org/10.1186/s40360-018-0281-7 |
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