First-in-human study assessing safety, tolerability, and pharmacokinetics of 2-hydroxybenzylamine acetate, a selective dicarbonyl electrophile scavenger, in healthy volunteers

BACKGROUND: 2-Hydroxybenzylamine (2-HOBA) is a selective scavenger of dicarbonyl electrophiles that protects proteins and lipids from being modified by these electrophiles. It is currently being developed for use as a nutritional supplement to help maintain good health and protect against the develo...

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Detalles Bibliográficos
Autores principales: Pitchford, Lisa M., Rathmacher, John A., Fuller, John C., Daniels, J. Scott, Morrison, Ryan D., Akers, Wendall S., Abumrad, Naji N., Amarnath, Venkataraman, Currey, Patricia M., Roberts, L. Jackson, Oates, John A., Boutaud, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321651/
https://www.ncbi.nlm.nih.gov/pubmed/30611293
http://dx.doi.org/10.1186/s40360-018-0281-7

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