Cargando…
Circular RNAs: a rising star in respiratory diseases
Circular RNAs (CircRNAs), as a new class of non-coding RNA molecules that, unlike linear RNAs, have covalently closed loop structures from the ligation of exons, introns, or both. CircRNAs are widely expressed in various organisms in a specie-, tissue-, disease- and developmental stage-specific mann...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321672/ https://www.ncbi.nlm.nih.gov/pubmed/30611252 http://dx.doi.org/10.1186/s12931-018-0962-1 |
_version_ | 1783385497588989952 |
---|---|
author | Wang, Jian Zhu, Mengchan Pan, Jue Chen, Cuicui Xia, Shijin Song, Yuanlin |
author_facet | Wang, Jian Zhu, Mengchan Pan, Jue Chen, Cuicui Xia, Shijin Song, Yuanlin |
author_sort | Wang, Jian |
collection | PubMed |
description | Circular RNAs (CircRNAs), as a new class of non-coding RNA molecules that, unlike linear RNAs, have covalently closed loop structures from the ligation of exons, introns, or both. CircRNAs are widely expressed in various organisms in a specie-, tissue-, disease- and developmental stage-specific manner, and have been demonstrated to play a vital role in the pathogenesis and progression of human diseases. An increasing number of recent studies has revealed that circRNAs are intensively associated with different respiratory diseases, including lung cancer, acute respiratory distress syndrome, pulmonary hypertension, pulmonary tuberculosis, and silicosis. However, to the best of our knowledge, there has been no systematic review of studies on the role of circRNAs in respiratory diseases. In this review, we elaborate on the biogenesis, functions, and identification of circRNAs and focus particularly on the potential implications of circRNAs in respiratory diseases. |
format | Online Article Text |
id | pubmed-6321672 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-63216722019-01-09 Circular RNAs: a rising star in respiratory diseases Wang, Jian Zhu, Mengchan Pan, Jue Chen, Cuicui Xia, Shijin Song, Yuanlin Respir Res Review Circular RNAs (CircRNAs), as a new class of non-coding RNA molecules that, unlike linear RNAs, have covalently closed loop structures from the ligation of exons, introns, or both. CircRNAs are widely expressed in various organisms in a specie-, tissue-, disease- and developmental stage-specific manner, and have been demonstrated to play a vital role in the pathogenesis and progression of human diseases. An increasing number of recent studies has revealed that circRNAs are intensively associated with different respiratory diseases, including lung cancer, acute respiratory distress syndrome, pulmonary hypertension, pulmonary tuberculosis, and silicosis. However, to the best of our knowledge, there has been no systematic review of studies on the role of circRNAs in respiratory diseases. In this review, we elaborate on the biogenesis, functions, and identification of circRNAs and focus particularly on the potential implications of circRNAs in respiratory diseases. BioMed Central 2019-01-05 2019 /pmc/articles/PMC6321672/ /pubmed/30611252 http://dx.doi.org/10.1186/s12931-018-0962-1 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Wang, Jian Zhu, Mengchan Pan, Jue Chen, Cuicui Xia, Shijin Song, Yuanlin Circular RNAs: a rising star in respiratory diseases |
title | Circular RNAs: a rising star in respiratory diseases |
title_full | Circular RNAs: a rising star in respiratory diseases |
title_fullStr | Circular RNAs: a rising star in respiratory diseases |
title_full_unstemmed | Circular RNAs: a rising star in respiratory diseases |
title_short | Circular RNAs: a rising star in respiratory diseases |
title_sort | circular rnas: a rising star in respiratory diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321672/ https://www.ncbi.nlm.nih.gov/pubmed/30611252 http://dx.doi.org/10.1186/s12931-018-0962-1 |
work_keys_str_mv | AT wangjian circularrnasarisingstarinrespiratorydiseases AT zhumengchan circularrnasarisingstarinrespiratorydiseases AT panjue circularrnasarisingstarinrespiratorydiseases AT chencuicui circularrnasarisingstarinrespiratorydiseases AT xiashijin circularrnasarisingstarinrespiratorydiseases AT songyuanlin circularrnasarisingstarinrespiratorydiseases |