Cargando…

Circular RNAs: a rising star in respiratory diseases

Circular RNAs (CircRNAs), as a new class of non-coding RNA molecules that, unlike linear RNAs, have covalently closed loop structures from the ligation of exons, introns, or both. CircRNAs are widely expressed in various organisms in a specie-, tissue-, disease- and developmental stage-specific mann...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Jian, Zhu, Mengchan, Pan, Jue, Chen, Cuicui, Xia, Shijin, Song, Yuanlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321672/
https://www.ncbi.nlm.nih.gov/pubmed/30611252
http://dx.doi.org/10.1186/s12931-018-0962-1
_version_ 1783385497588989952
author Wang, Jian
Zhu, Mengchan
Pan, Jue
Chen, Cuicui
Xia, Shijin
Song, Yuanlin
author_facet Wang, Jian
Zhu, Mengchan
Pan, Jue
Chen, Cuicui
Xia, Shijin
Song, Yuanlin
author_sort Wang, Jian
collection PubMed
description Circular RNAs (CircRNAs), as a new class of non-coding RNA molecules that, unlike linear RNAs, have covalently closed loop structures from the ligation of exons, introns, or both. CircRNAs are widely expressed in various organisms in a specie-, tissue-, disease- and developmental stage-specific manner, and have been demonstrated to play a vital role in the pathogenesis and progression of human diseases. An increasing number of recent studies has revealed that circRNAs are intensively associated with different respiratory diseases, including lung cancer, acute respiratory distress syndrome, pulmonary hypertension, pulmonary tuberculosis, and silicosis. However, to the best of our knowledge, there has been no systematic review of studies on the role of circRNAs in respiratory diseases. In this review, we elaborate on the biogenesis, functions, and identification of circRNAs and focus particularly on the potential implications of circRNAs in respiratory diseases.
format Online
Article
Text
id pubmed-6321672
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-63216722019-01-09 Circular RNAs: a rising star in respiratory diseases Wang, Jian Zhu, Mengchan Pan, Jue Chen, Cuicui Xia, Shijin Song, Yuanlin Respir Res Review Circular RNAs (CircRNAs), as a new class of non-coding RNA molecules that, unlike linear RNAs, have covalently closed loop structures from the ligation of exons, introns, or both. CircRNAs are widely expressed in various organisms in a specie-, tissue-, disease- and developmental stage-specific manner, and have been demonstrated to play a vital role in the pathogenesis and progression of human diseases. An increasing number of recent studies has revealed that circRNAs are intensively associated with different respiratory diseases, including lung cancer, acute respiratory distress syndrome, pulmonary hypertension, pulmonary tuberculosis, and silicosis. However, to the best of our knowledge, there has been no systematic review of studies on the role of circRNAs in respiratory diseases. In this review, we elaborate on the biogenesis, functions, and identification of circRNAs and focus particularly on the potential implications of circRNAs in respiratory diseases. BioMed Central 2019-01-05 2019 /pmc/articles/PMC6321672/ /pubmed/30611252 http://dx.doi.org/10.1186/s12931-018-0962-1 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Wang, Jian
Zhu, Mengchan
Pan, Jue
Chen, Cuicui
Xia, Shijin
Song, Yuanlin
Circular RNAs: a rising star in respiratory diseases
title Circular RNAs: a rising star in respiratory diseases
title_full Circular RNAs: a rising star in respiratory diseases
title_fullStr Circular RNAs: a rising star in respiratory diseases
title_full_unstemmed Circular RNAs: a rising star in respiratory diseases
title_short Circular RNAs: a rising star in respiratory diseases
title_sort circular rnas: a rising star in respiratory diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321672/
https://www.ncbi.nlm.nih.gov/pubmed/30611252
http://dx.doi.org/10.1186/s12931-018-0962-1
work_keys_str_mv AT wangjian circularrnasarisingstarinrespiratorydiseases
AT zhumengchan circularrnasarisingstarinrespiratorydiseases
AT panjue circularrnasarisingstarinrespiratorydiseases
AT chencuicui circularrnasarisingstarinrespiratorydiseases
AT xiashijin circularrnasarisingstarinrespiratorydiseases
AT songyuanlin circularrnasarisingstarinrespiratorydiseases