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H. pylori isolates with amino acid sequence polymorphisms as presence of both HtrA-L171 & CagL-Y58/E59 increase the risk of gastric cancer

BACKGROUND: H. pylori CagL-Y58/E59 increase gastric cancer risk by stronger binding with integrin to faciliate type IV secretory system (T4SS). H. pylori can secrete high temperature requirement A (HtrA) to mediate E-Cadherin cleavage for gastric epithelial junction disruption, so H. pylori CagL can...

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Detalles Bibliográficos
Autores principales:	Yeh, Yi-Chun, Kuo, Hsin-Yu, Chang, Wei-Lun, Yang, Hsiao-Bai, Lu, Cheng-Chan, Cheng, Hsiu-Chi, Wu, Ming-Shiang, Sheu, Bor-Shyang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321681/ https://www.ncbi.nlm.nih.gov/pubmed/30611258 http://dx.doi.org/10.1186/s12929-019-0498-9

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