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Phytochemical Profile, Antioxidant and Antidiabetic Activities of Adansonia digitata L. (Baobab) from Mali, as a Source of Health-Promoting Compounds

Background: Adansonia digitata L. (Malvaceae), also known as baobab, is a tree attracting recent interest especially due to the high nutritional value of the fruit pulp. However, few studies are reported on the secondary metabolite content, showing high variability depending on the geographic region...

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Autores principales: Braca, Alessandra, Sinisgalli, Chiara, De Leo, Marinella, Muscatello, Beatrice, Cioni, Pier Luigi, Milella, Luigi, Ostuni, Angela, Giani, Sergio, Sanogo, Rokia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321735/
https://www.ncbi.nlm.nih.gov/pubmed/30486448
http://dx.doi.org/10.3390/molecules23123104
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author Braca, Alessandra
Sinisgalli, Chiara
De Leo, Marinella
Muscatello, Beatrice
Cioni, Pier Luigi
Milella, Luigi
Ostuni, Angela
Giani, Sergio
Sanogo, Rokia
author_facet Braca, Alessandra
Sinisgalli, Chiara
De Leo, Marinella
Muscatello, Beatrice
Cioni, Pier Luigi
Milella, Luigi
Ostuni, Angela
Giani, Sergio
Sanogo, Rokia
author_sort Braca, Alessandra
collection PubMed
description Background: Adansonia digitata L. (Malvaceae), also known as baobab, is a tree attracting recent interest especially due to the high nutritional value of the fruit pulp. However, few studies are reported on the secondary metabolite content, showing high variability depending on the geographic region. Methods: In this study, the chemical profiles of Malian commercial baobab fruits and leaves, focused on phenolic content, were investigated by HPLC coupled with a photodiode array (PDA)/UV and an electrospray ionization (ESI) mass spectrometer (MS) and gas chromatography (GC)/MS. In addition, the extracts of fruit pulps obtained from three different markets (Fruits 1, 2, and 3) were evaluated for their total phenolic content (TPC), antioxidant activity and α-glucosidase inhibition. Results: Baobab fruit pulps were found to be rich in procyanidins and flavonol glycosides, with tiliroside as the major constituent. The baobab leaves showed a similar profile respect to the fruits, but with more detected phenolics. All fruit pulp extracts exerted antioxidant activity (highest for Fruit 3) and higher α-glucosidase inhibition than acarbose used as standard. Conclusions: This study confirmed the variability of baobab with different origins and indicated Malian species baobab as a promising source of health-promoting substances.
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spelling pubmed-63217352019-01-14 Phytochemical Profile, Antioxidant and Antidiabetic Activities of Adansonia digitata L. (Baobab) from Mali, as a Source of Health-Promoting Compounds Braca, Alessandra Sinisgalli, Chiara De Leo, Marinella Muscatello, Beatrice Cioni, Pier Luigi Milella, Luigi Ostuni, Angela Giani, Sergio Sanogo, Rokia Molecules Article Background: Adansonia digitata L. (Malvaceae), also known as baobab, is a tree attracting recent interest especially due to the high nutritional value of the fruit pulp. However, few studies are reported on the secondary metabolite content, showing high variability depending on the geographic region. Methods: In this study, the chemical profiles of Malian commercial baobab fruits and leaves, focused on phenolic content, were investigated by HPLC coupled with a photodiode array (PDA)/UV and an electrospray ionization (ESI) mass spectrometer (MS) and gas chromatography (GC)/MS. In addition, the extracts of fruit pulps obtained from three different markets (Fruits 1, 2, and 3) were evaluated for their total phenolic content (TPC), antioxidant activity and α-glucosidase inhibition. Results: Baobab fruit pulps were found to be rich in procyanidins and flavonol glycosides, with tiliroside as the major constituent. The baobab leaves showed a similar profile respect to the fruits, but with more detected phenolics. All fruit pulp extracts exerted antioxidant activity (highest for Fruit 3) and higher α-glucosidase inhibition than acarbose used as standard. Conclusions: This study confirmed the variability of baobab with different origins and indicated Malian species baobab as a promising source of health-promoting substances. MDPI 2018-11-27 /pmc/articles/PMC6321735/ /pubmed/30486448 http://dx.doi.org/10.3390/molecules23123104 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Braca, Alessandra
Sinisgalli, Chiara
De Leo, Marinella
Muscatello, Beatrice
Cioni, Pier Luigi
Milella, Luigi
Ostuni, Angela
Giani, Sergio
Sanogo, Rokia
Phytochemical Profile, Antioxidant and Antidiabetic Activities of Adansonia digitata L. (Baobab) from Mali, as a Source of Health-Promoting Compounds
title Phytochemical Profile, Antioxidant and Antidiabetic Activities of Adansonia digitata L. (Baobab) from Mali, as a Source of Health-Promoting Compounds
title_full Phytochemical Profile, Antioxidant and Antidiabetic Activities of Adansonia digitata L. (Baobab) from Mali, as a Source of Health-Promoting Compounds
title_fullStr Phytochemical Profile, Antioxidant and Antidiabetic Activities of Adansonia digitata L. (Baobab) from Mali, as a Source of Health-Promoting Compounds
title_full_unstemmed Phytochemical Profile, Antioxidant and Antidiabetic Activities of Adansonia digitata L. (Baobab) from Mali, as a Source of Health-Promoting Compounds
title_short Phytochemical Profile, Antioxidant and Antidiabetic Activities of Adansonia digitata L. (Baobab) from Mali, as a Source of Health-Promoting Compounds
title_sort phytochemical profile, antioxidant and antidiabetic activities of adansonia digitata l. (baobab) from mali, as a source of health-promoting compounds
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321735/
https://www.ncbi.nlm.nih.gov/pubmed/30486448
http://dx.doi.org/10.3390/molecules23123104
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