Cargando…

Hif-1α–Induced Expression of Il-1β Protects against Mycobacterial Infection in Zebrafish

Drug-resistant mycobacteria are a rising problem worldwide. There is an urgent need to understand the immune response to tuberculosis to identify host targets that, if targeted therapeutically, could be used to tackle these currently untreatable infections. In this study we use an Il-1β fluorescent...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ogryzko, Nikolay V., Lewis, Amy, Wilson, Heather L., Meijer, Annemarie H., Renshaw, Stephen A., Elks, Philip M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AAI 2019
Materias:	Infectious Disease and Host Response
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321843/ https://www.ncbi.nlm.nih.gov/pubmed/30552162 http://dx.doi.org/10.4049/jimmunol.1801139

Ejemplares similares

Cysteine-Reactive Free ISG15 Generates IL-1β–Producing CD8α(+) Dendritic Cells at the Site of Infection
por: Napolitano, Anna, et al.
Publicado: (2018)

Delinking CARD9 and IL-17: CARD9 Protects against Candida tropicalis Infection through a TNF-α–Dependent, IL-17–Independent Mechanism
por: Whibley, Natasha, et al.
Publicado: (2015)

Type I IFN Induces IL-10 Production in an IL-27–Independent Manner and Blocks Responsiveness to IFN-γ for Production of IL-12 and Bacterial Killing in Mycobacterium tuberculosis–Infected Macrophages
por: McNab, Finlay W., et al.
Publicado: (2014)

Cyclooxygenase-Derived Prostaglandin E(2) Drives IL-1–Independent Mycobacterium bovis Bacille Calmette-Guérin–Triggered Skin Dendritic Cell Migration to Draining Lymph Node
por: Krmeská, Veronika, et al.
Publicado: (2022)

T Cell–Derived IL-10 Impairs Host Resistance to Mycobacterium tuberculosis Infection
por: Moreira-Teixeira, Lúcia, et al.
Publicado: (2017)

IL-27 Induced by Select Candida spp. via TLR7/NOD2 Signaling and IFN-β Production Inhibits Fungal Clearance
por: Patin, Emmanuel C., et al.
Publicado: (2016)

Mapping the Binding Site of a Cross-Reactive Plasmodium falciparum PfEMP1 Monoclonal Antibody Inhibitory of ICAM-1 Binding
por: Lennartz, Frank, et al.
Publicado: (2015)

Terminal Effector CD8 T Cells Defined by an IKZF2(+)IL-7R(−) Transcriptional Signature Express FcγRIIIA, Expand in HIV Infection, and Mediate Potent HIV-Specific Antibody-Dependent Cellular Cytotoxicity
por: Naluyima, Prossy, et al.
Publicado: (2019)

CD4(+) T Cell Responses to the Plasmodium falciparum Erythrocyte Membrane Protein 1 in Children with Mild Malaria
por: Gitau, Evelyn N., et al.
Publicado: (2014)

Exhausted CD4(+) T Cells during Malaria Exhibit Reduced mTORc1 Activity Correlated with Loss of T-bet Expression
por: Villegas-Mendez, Ana, et al.
Publicado: (2020)

PI3Kδ Regulates the Magnitude of CD8(+) T Cell Responses after Challenge with Listeria monocytogenes
por: Pearce, Verity Q., et al.
Publicado: (2015)

Primary EBV Infection Induces an Acute Wave of Activated Antigen-Specific Cytotoxic CD4(+) T Cells
por: Meckiff, Benjamin J., et al.
Publicado: (2019)

Monocyte Adhesion, Migration, and Extracellular Matrix Breakdown Are Regulated by Integrin αVβ3 in Mycobacterium tuberculosis Infection
por: Brilha, Sara, et al.
Publicado: (2017)

Retinoic Acid–Related Orphan Receptor α Is Required for Generation of Th2 Cells in Type 2 Pulmonary Inflammation
por: Roberts, Joseph, et al.
Publicado: (2023)

MyD88 Signaling Inhibits Protective Immunity to the Gastrointestinal Helminth Parasite Heligmosomoides polygyrus
por: Reynolds, Lisa A., et al.
Publicado: (2014)

T Cell Immunity to the Alkyl Hydroperoxide Reductase of Burkholderia pseudomallei: A Correlate of Disease Outcome in Acute Melioidosis
por: Reynolds, Catherine, et al.
Publicado: (2015)

Control of Viremia Enables Acquisition of Resting Memory B Cells with Age and Normalization of Activated B Cell Phenotypes in HIV-Infected Children
por: Muema, Daniel M., et al.
Publicado: (2015)

Cathelicidins Have Direct Antiviral Activity against Respiratory Syncytial Virus In Vitro and Protective Function In Vivo in Mice and Humans
por: Currie, Silke M., et al.
Publicado: (2016)

Cytotoxic Mediators in Paradoxical HIV–Tuberculosis Immune Reconstitution Inflammatory Syndrome
por: Wilkinson, Katalin A., et al.
Publicado: (2015)

The Cellular Localization of Human Cytomegalovirus Glycoprotein Expression Greatly Influences the Frequency and Functional Phenotype of Specific CD4(+) T Cell Responses
por: Pachnio, Annette, et al.
Publicado: (2015)

Type I IFN Inhibits Alternative Macrophage Activation during Mycobacterium tuberculosis Infection and Leads to Enhanced Protection in the Absence of IFN-γ Signaling
por: Moreira-Teixeira, Lúcia, et al.
Publicado: (2016)

Dichotomy between T Cell and B Cell Tolerance to Neonatal Retroviral Infection Permits T Cell Therapy
por: Mavrommatis, Bettina, et al.
Publicado: (2016)

Characterizing the Mechanisms of Nonopsonic Uptake of Cryptococci by Macrophages
por: Lim, Jenson, et al.
Publicado: (2018)

Cytomegalovirus Exposure in the Elderly Does Not Reduce CD8 T Cell Repertoire Diversity
por: Lindau, Paul, et al.
Publicado: (2019)

The Threshold of Protection from Liver-Stage Malaria Relies on a Fine Balance between the Number of Infected Hepatocytes and Effector CD8(+) T Cells Present in the Liver
por: Spencer, Alexandra J., et al.
Publicado: (2017)

Egr2 and 3 Inhibit T-bet–Mediated IFN-γ Production in T Cells
por: Singh, Randeep, et al.
Publicado: (2017)

A Requirement for Neutrophil Glycosaminoglycans in Chemokine:Receptor Interactions Is Revealed by the Streptococcal Protease SpyCEP
por: Goldblatt, Jennifer, et al.
Publicado: (2019)

Mice Deficient in T-bet Form Inducible NO Synthase–Positive Granulomas That Fail to Constrain Salmonella
por: Perez-Toledo, Marisol, et al.
Publicado: (2020)

Stochastic Expansions Maintain the Clonal Stability of CD8(+) T Cell Populations Undergoing Memory Inflation Driven by Murine Cytomegalovirus
por: Smith, Corinne J., et al.
Publicado: (2020)

Nontypeable Haemophilus influenzae P5 Binds Human C4b-Binding Protein, Promoting Serum Resistance
por: Thofte, Oskar, et al.
Publicado: (2021)

Vaccinia Virus Infection Inhibits Skin Dendritic Cell Migration to the Draining Lymph Node
por: Aggio, Juliana Bernardi, et al.
Publicado: (2021)

Group 2 Innate Lymphoid Cells Are Detrimental to the Control of Infection with Francisella tularensis
por: Dow, Joshua, et al.
Publicado: (2023)

Annexin A1 Attenuates Neutrophil Migration and IL-6 Expression through Fpr2 in a Mouse Model of Streptococcus suis-Induced Meningitis
por: Ni, Chengpei, et al.
Publicado: (2021)

IRE1α-Driven Inflammation Promotes Clearance of Citrobacter rodentium Infection
por: Sweet, Lydia A., et al.
Publicado: (2022)

OT-1 mice display minimal upper genital tract pathology following primary intravaginal Chlamydia muridarum infection
por: Manam, Srikanth, et al.
Publicado: (2013)

Yersiniabactin-Producing Adherent/Invasive Escherichia coli Promotes Inflammation-Associated Fibrosis in Gnotobiotic Il10(−/−) Mice
por: Ellermann, Melissa, et al.
Publicado: (2019)

Exploring the HIFs, buts and maybes of hypoxia signalling in disease: lessons from zebrafish models
por: Elks, Philip M., et al.
Publicado: (2015)

The Dynll1-Cox4i1 Complex Regulates Intracellular Pathogen Clearance via Release of Mitochondrial Reactive Oxygen Species
por: Yuan, Jiangbei, et al.
Publicado: (2020)

Serum Levels of Syndecan-1 in Patients With Kawasaki Disease
por: Luo, Li, et al.
Publicado: (2019)

Activation of the Endoplasmic Reticulum Stress Response Impacts the NOD1 Signaling Pathway
por: Mendez, Jonathan M., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_8u7ga8lip830kqce3okibukni6