Mutation of Influenza A Virus PA-X Decreases Pathogenicity in Chicken Embryos and Can Increase the Yield of Reassortant Candidate Vaccine Viruses

The PA-X protein of influenza A virus has roles in host cell shutoff and viral pathogenesis. While most strains are predicted to encode PA-X, strain-dependent variations in activity have been noted. We found that PA-X protein from the A/PR/8/34 (PR8) strain had significantly lower repressive activit...

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Detalles Bibliográficos
Autores principales: Hussain, Saira, Turnbull, Matthew L., Wise, Helen M., Jagger, Brett W., Beard, Philippa M., Kovacikova, Kristina, Taubenberger, Jeffery K., Vervelde, Lonneke, Engelhardt, Othmar G., Digard, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Pathogenesis and Immunity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321911/
https://www.ncbi.nlm.nih.gov/pubmed/30381488
http://dx.doi.org/10.1128/JVI.01551-18

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