Preclinical tissue distribution and metabolic correlations of vigabatrin, an antiepileptic drug associated with potential use‐limiting visual field defects

Vigabatrin (VGB; (S)‐(+)/(R)‐(‐) 4‐aminohex‐5‐enoic acid), an antiepileptic irreversibly inactivating GABA transaminase (GABA‐T), manifests use‐limiting ocular toxicity. Hypothesizing that the active S enantiomer of VGB would preferentially accumulate in eye and visual cortex (VC) as one potential m...

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Detalles Bibliográficos
Autores principales: Walters, Dana C., Jansen, Erwin E. W., Ainslie, Garrett R., Salomons, Gajja S., Brown, Madalyn N., Schmidt, Michelle A., Roullet, Jean‐Baptiste, Gibson, K. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321982/
https://www.ncbi.nlm.nih.gov/pubmed/30631446
http://dx.doi.org/10.1002/prp2.456

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