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Stevens Johnson Syndrome with Vaginal Pain and Lesions as Initial Presentation

Patient: Female, 27 Final Diagnosis: Stevens Johnsons syndrome Symptoms: Vaginal ulceration Medication: TMP-STX Clinical Procedure: — Specialty: Dermatology OBJECTIVE: Unusual clinical course BACKGROUND: Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are causes of rare but life-...

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Autores principales: Mergler, Reid, Chuang, Meleen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322057/
https://www.ncbi.nlm.nih.gov/pubmed/30573724
http://dx.doi.org/10.12659/AJCR.912123
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author Mergler, Reid
Chuang, Meleen
author_facet Mergler, Reid
Chuang, Meleen
author_sort Mergler, Reid
collection PubMed
description Patient: Female, 27 Final Diagnosis: Stevens Johnsons syndrome Symptoms: Vaginal ulceration Medication: TMP-STX Clinical Procedure: — Specialty: Dermatology OBJECTIVE: Unusual clinical course BACKGROUND: Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are causes of rare but life-threatening emergencies characterized by desquamation of the skin and mucosa. As SJS most commonly presents with skin rash followed by mucosal involvement, we present a case of vulvovaginal lesions as the initial presentation with progression to SJS after re-exposure to the culprit drug. CASE REPORT: A 27-year-old female with acute cystitis was given trimethoprim-sulfamethoxazole. After 2 days, she reported vaginal pain. Three days later, she was hospitalized with vulvovaginal ulcerations and restarted on trimethoprimsulfamethoxazole, leading to worsening vaginal lesions with rapid desquamation of conjunctival and oropharyngeal involvement. Biopsies of arm lesions revealed SJS. CONCLUSIONS: It is important to recognize SJS as a rare but life-threatening cause of vulvovaginal ulceration, as early diagnosis is vital for successful treatment.
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spelling pubmed-63220572019-01-25 Stevens Johnson Syndrome with Vaginal Pain and Lesions as Initial Presentation Mergler, Reid Chuang, Meleen Am J Case Rep Articles Patient: Female, 27 Final Diagnosis: Stevens Johnsons syndrome Symptoms: Vaginal ulceration Medication: TMP-STX Clinical Procedure: — Specialty: Dermatology OBJECTIVE: Unusual clinical course BACKGROUND: Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are causes of rare but life-threatening emergencies characterized by desquamation of the skin and mucosa. As SJS most commonly presents with skin rash followed by mucosal involvement, we present a case of vulvovaginal lesions as the initial presentation with progression to SJS after re-exposure to the culprit drug. CASE REPORT: A 27-year-old female with acute cystitis was given trimethoprim-sulfamethoxazole. After 2 days, she reported vaginal pain. Three days later, she was hospitalized with vulvovaginal ulcerations and restarted on trimethoprimsulfamethoxazole, leading to worsening vaginal lesions with rapid desquamation of conjunctival and oropharyngeal involvement. Biopsies of arm lesions revealed SJS. CONCLUSIONS: It is important to recognize SJS as a rare but life-threatening cause of vulvovaginal ulceration, as early diagnosis is vital for successful treatment. International Scientific Literature, Inc. 2018-12-21 /pmc/articles/PMC6322057/ /pubmed/30573724 http://dx.doi.org/10.12659/AJCR.912123 Text en © Am J Case Rep, 2018 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Articles
Mergler, Reid
Chuang, Meleen
Stevens Johnson Syndrome with Vaginal Pain and Lesions as Initial Presentation
title Stevens Johnson Syndrome with Vaginal Pain and Lesions as Initial Presentation
title_full Stevens Johnson Syndrome with Vaginal Pain and Lesions as Initial Presentation
title_fullStr Stevens Johnson Syndrome with Vaginal Pain and Lesions as Initial Presentation
title_full_unstemmed Stevens Johnson Syndrome with Vaginal Pain and Lesions as Initial Presentation
title_short Stevens Johnson Syndrome with Vaginal Pain and Lesions as Initial Presentation
title_sort stevens johnson syndrome with vaginal pain and lesions as initial presentation
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322057/
https://www.ncbi.nlm.nih.gov/pubmed/30573724
http://dx.doi.org/10.12659/AJCR.912123
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