Cargando…
Stevens Johnson Syndrome with Vaginal Pain and Lesions as Initial Presentation
Patient: Female, 27 Final Diagnosis: Stevens Johnsons syndrome Symptoms: Vaginal ulceration Medication: TMP-STX Clinical Procedure: — Specialty: Dermatology OBJECTIVE: Unusual clinical course BACKGROUND: Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are causes of rare but life-...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322057/ https://www.ncbi.nlm.nih.gov/pubmed/30573724 http://dx.doi.org/10.12659/AJCR.912123 |
_version_ | 1783385549554319360 |
---|---|
author | Mergler, Reid Chuang, Meleen |
author_facet | Mergler, Reid Chuang, Meleen |
author_sort | Mergler, Reid |
collection | PubMed |
description | Patient: Female, 27 Final Diagnosis: Stevens Johnsons syndrome Symptoms: Vaginal ulceration Medication: TMP-STX Clinical Procedure: — Specialty: Dermatology OBJECTIVE: Unusual clinical course BACKGROUND: Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are causes of rare but life-threatening emergencies characterized by desquamation of the skin and mucosa. As SJS most commonly presents with skin rash followed by mucosal involvement, we present a case of vulvovaginal lesions as the initial presentation with progression to SJS after re-exposure to the culprit drug. CASE REPORT: A 27-year-old female with acute cystitis was given trimethoprim-sulfamethoxazole. After 2 days, she reported vaginal pain. Three days later, she was hospitalized with vulvovaginal ulcerations and restarted on trimethoprimsulfamethoxazole, leading to worsening vaginal lesions with rapid desquamation of conjunctival and oropharyngeal involvement. Biopsies of arm lesions revealed SJS. CONCLUSIONS: It is important to recognize SJS as a rare but life-threatening cause of vulvovaginal ulceration, as early diagnosis is vital for successful treatment. |
format | Online Article Text |
id | pubmed-6322057 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63220572019-01-25 Stevens Johnson Syndrome with Vaginal Pain and Lesions as Initial Presentation Mergler, Reid Chuang, Meleen Am J Case Rep Articles Patient: Female, 27 Final Diagnosis: Stevens Johnsons syndrome Symptoms: Vaginal ulceration Medication: TMP-STX Clinical Procedure: — Specialty: Dermatology OBJECTIVE: Unusual clinical course BACKGROUND: Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are causes of rare but life-threatening emergencies characterized by desquamation of the skin and mucosa. As SJS most commonly presents with skin rash followed by mucosal involvement, we present a case of vulvovaginal lesions as the initial presentation with progression to SJS after re-exposure to the culprit drug. CASE REPORT: A 27-year-old female with acute cystitis was given trimethoprim-sulfamethoxazole. After 2 days, she reported vaginal pain. Three days later, she was hospitalized with vulvovaginal ulcerations and restarted on trimethoprimsulfamethoxazole, leading to worsening vaginal lesions with rapid desquamation of conjunctival and oropharyngeal involvement. Biopsies of arm lesions revealed SJS. CONCLUSIONS: It is important to recognize SJS as a rare but life-threatening cause of vulvovaginal ulceration, as early diagnosis is vital for successful treatment. International Scientific Literature, Inc. 2018-12-21 /pmc/articles/PMC6322057/ /pubmed/30573724 http://dx.doi.org/10.12659/AJCR.912123 Text en © Am J Case Rep, 2018 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Articles Mergler, Reid Chuang, Meleen Stevens Johnson Syndrome with Vaginal Pain and Lesions as Initial Presentation |
title | Stevens Johnson Syndrome with Vaginal Pain and Lesions as Initial Presentation |
title_full | Stevens Johnson Syndrome with Vaginal Pain and Lesions as Initial Presentation |
title_fullStr | Stevens Johnson Syndrome with Vaginal Pain and Lesions as Initial Presentation |
title_full_unstemmed | Stevens Johnson Syndrome with Vaginal Pain and Lesions as Initial Presentation |
title_short | Stevens Johnson Syndrome with Vaginal Pain and Lesions as Initial Presentation |
title_sort | stevens johnson syndrome with vaginal pain and lesions as initial presentation |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322057/ https://www.ncbi.nlm.nih.gov/pubmed/30573724 http://dx.doi.org/10.12659/AJCR.912123 |
work_keys_str_mv | AT merglerreid stevensjohnsonsyndromewithvaginalpainandlesionsasinitialpresentation AT chuangmeleen stevensjohnsonsyndromewithvaginalpainandlesionsasinitialpresentation |