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Transcranial direct current stimulation enhances theory of mind in Parkinson’s disease patients with mild cognitive impairment: a randomized, double-blind, sham-controlled study
BACKGROUND: Parkinson’s Disease (PD) with mild cognitive impairment (MCI) (PD-MCI) represents one of the most dreaded complications for patients with PD and is associated with a higher risk of developing dementia. Although transcranial direct current stimulation (tDCS) has been demonstrated to impro...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322239/ https://www.ncbi.nlm.nih.gov/pubmed/30627430 http://dx.doi.org/10.1186/s40035-018-0141-9 |
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author | Adenzato, Mauro Manenti, Rosa Enrici, Ivan Gobbi, Elena Brambilla, Michela Alberici, Antonella Cotelli, Maria Sofia Padovani, Alessandro Borroni, Barbara Cotelli, Maria |
author_facet | Adenzato, Mauro Manenti, Rosa Enrici, Ivan Gobbi, Elena Brambilla, Michela Alberici, Antonella Cotelli, Maria Sofia Padovani, Alessandro Borroni, Barbara Cotelli, Maria |
author_sort | Adenzato, Mauro |
collection | PubMed |
description | BACKGROUND: Parkinson’s Disease (PD) with mild cognitive impairment (MCI) (PD-MCI) represents one of the most dreaded complications for patients with PD and is associated with a higher risk of developing dementia. Although transcranial direct current stimulation (tDCS) has been demonstrated to improve motor and non-motor symptoms in PD, to date, no study has investigated the effects of tDCS on Theory of Mind (ToM), i.e., the ability to understand and predict other people’s behaviours, in PD-MCI. METHODS: In this randomized, double-blind, sham-controlled study, we applied active tDCS over the medial frontal cortex (MFC) to modulate ToM performance in twenty patients with PD-MCI. Twenty matched healthy controls (HC) were also enrolled and were asked to perform the ToM task without receiving tDCS. RESULTS: In the patients with PD-MCI, i) ToM performance was worse than that in the HC, ii) ToM abilities were poorer in those with fronto-executive difficulties, and iii) tDCS over the MFC led to significant shortening of latency for ToM tasks. CONCLUSIONS: We show for the first time that active tDCS over the MFC enhances ToM in patients with PD-MCI, and suggest that non-invasive brain stimulation could be used to ameliorate ToM deficits observed in these patients. |
format | Online Article Text |
id | pubmed-6322239 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-63222392019-01-09 Transcranial direct current stimulation enhances theory of mind in Parkinson’s disease patients with mild cognitive impairment: a randomized, double-blind, sham-controlled study Adenzato, Mauro Manenti, Rosa Enrici, Ivan Gobbi, Elena Brambilla, Michela Alberici, Antonella Cotelli, Maria Sofia Padovani, Alessandro Borroni, Barbara Cotelli, Maria Transl Neurodegener Research BACKGROUND: Parkinson’s Disease (PD) with mild cognitive impairment (MCI) (PD-MCI) represents one of the most dreaded complications for patients with PD and is associated with a higher risk of developing dementia. Although transcranial direct current stimulation (tDCS) has been demonstrated to improve motor and non-motor symptoms in PD, to date, no study has investigated the effects of tDCS on Theory of Mind (ToM), i.e., the ability to understand and predict other people’s behaviours, in PD-MCI. METHODS: In this randomized, double-blind, sham-controlled study, we applied active tDCS over the medial frontal cortex (MFC) to modulate ToM performance in twenty patients with PD-MCI. Twenty matched healthy controls (HC) were also enrolled and were asked to perform the ToM task without receiving tDCS. RESULTS: In the patients with PD-MCI, i) ToM performance was worse than that in the HC, ii) ToM abilities were poorer in those with fronto-executive difficulties, and iii) tDCS over the MFC led to significant shortening of latency for ToM tasks. CONCLUSIONS: We show for the first time that active tDCS over the MFC enhances ToM in patients with PD-MCI, and suggest that non-invasive brain stimulation could be used to ameliorate ToM deficits observed in these patients. BioMed Central 2019-01-07 /pmc/articles/PMC6322239/ /pubmed/30627430 http://dx.doi.org/10.1186/s40035-018-0141-9 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Adenzato, Mauro Manenti, Rosa Enrici, Ivan Gobbi, Elena Brambilla, Michela Alberici, Antonella Cotelli, Maria Sofia Padovani, Alessandro Borroni, Barbara Cotelli, Maria Transcranial direct current stimulation enhances theory of mind in Parkinson’s disease patients with mild cognitive impairment: a randomized, double-blind, sham-controlled study |
title | Transcranial direct current stimulation enhances theory of mind in Parkinson’s disease patients with mild cognitive impairment: a randomized, double-blind, sham-controlled study |
title_full | Transcranial direct current stimulation enhances theory of mind in Parkinson’s disease patients with mild cognitive impairment: a randomized, double-blind, sham-controlled study |
title_fullStr | Transcranial direct current stimulation enhances theory of mind in Parkinson’s disease patients with mild cognitive impairment: a randomized, double-blind, sham-controlled study |
title_full_unstemmed | Transcranial direct current stimulation enhances theory of mind in Parkinson’s disease patients with mild cognitive impairment: a randomized, double-blind, sham-controlled study |
title_short | Transcranial direct current stimulation enhances theory of mind in Parkinson’s disease patients with mild cognitive impairment: a randomized, double-blind, sham-controlled study |
title_sort | transcranial direct current stimulation enhances theory of mind in parkinson’s disease patients with mild cognitive impairment: a randomized, double-blind, sham-controlled study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322239/ https://www.ncbi.nlm.nih.gov/pubmed/30627430 http://dx.doi.org/10.1186/s40035-018-0141-9 |
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