Cargando…

Tai chi for treating osteopenia and primary osteoporosis: a meta-analysis and trial sequential analysis

PURPOSE: The aim of this meta-analysis was to evaluate the efficacy of Tai chi (TC) as an adjuvant treatment for osteopenia and primary osteoporosis. METHODS: We went through eight databases to identify relevant randomized controlled trials that compared TC with a control group. The primary outcome...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Yili, Chai, Yan, Pan, Xiaojie, Shen, Hao, Wei, Xu, Xie, Yanming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322510/
https://www.ncbi.nlm.nih.gov/pubmed/30655662
http://dx.doi.org/10.2147/CIA.S187588
_version_ 1783385620168572928
author Zhang, Yili
Chai, Yan
Pan, Xiaojie
Shen, Hao
Wei, Xu
Xie, Yanming
author_facet Zhang, Yili
Chai, Yan
Pan, Xiaojie
Shen, Hao
Wei, Xu
Xie, Yanming
author_sort Zhang, Yili
collection PubMed
description PURPOSE: The aim of this meta-analysis was to evaluate the efficacy of Tai chi (TC) as an adjuvant treatment for osteopenia and primary osteoporosis. METHODS: We went through eight databases to identify relevant randomized controlled trials that compared TC with a control group. The primary outcome was osteoporosis-related fractures (fracture incidence). Meta-analyses and trial sequential analyses (TSA) were conducted using RevMan 5.3 and TSA 0.9. RESULTS: Fifteen randomized controlled trials involving a total of 857 patients were included in the analyses. No trials reported primary outcome; however, bone mineral density (BMD) values differed significantly in subgroup 1 (TC vs no treatment; weighted mean difference [WMD] =0.05 g/cm(2), 95% CI 0.03 to 0.07; P<0.00001; P for heterogeneity =0.22, I(2)=22%) and subgroup 2 (TC vs conventional treatments; WMD =0.16 g/cm(2), 95% CI 0.11 to 0.21; P<0.00001; P for heterogeneity =0.008, I(2)=75%). In addition, two trials compared TC with conventional treatments, which found a significant difference in bone gla protein (standardized mean difference =−1.18, 95% CI −1.66 to −0.70; P<0.00001; P for heterogeneity =0.58, I(2)=75%). The results of the BMD were confirmed by TSA. Also, TC may have a certain effect on the relief of osteoporotic pain (WMD = −2.61, 95% CI −3.51 to −1.71; WMD = −1.39, 95% CI −2.01 to −0.77). However, it did not promote the quality of life, level of serum calcium, serum phosphorus, and also had no effect on bone turnover markers. CONCLUSION: Although there is no study monitoring fracture incidence, TC may be beneficial for patients in improving BMD values, level of bone gla protein, and relieving osteoporotic pain. However, due to the low methodological quality, current evidence for treating osteopenia and primary osteoporosis through TC is insufficient.
format Online
Article
Text
id pubmed-6322510
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-63225102019-01-17 Tai chi for treating osteopenia and primary osteoporosis: a meta-analysis and trial sequential analysis Zhang, Yili Chai, Yan Pan, Xiaojie Shen, Hao Wei, Xu Xie, Yanming Clin Interv Aging Review PURPOSE: The aim of this meta-analysis was to evaluate the efficacy of Tai chi (TC) as an adjuvant treatment for osteopenia and primary osteoporosis. METHODS: We went through eight databases to identify relevant randomized controlled trials that compared TC with a control group. The primary outcome was osteoporosis-related fractures (fracture incidence). Meta-analyses and trial sequential analyses (TSA) were conducted using RevMan 5.3 and TSA 0.9. RESULTS: Fifteen randomized controlled trials involving a total of 857 patients were included in the analyses. No trials reported primary outcome; however, bone mineral density (BMD) values differed significantly in subgroup 1 (TC vs no treatment; weighted mean difference [WMD] =0.05 g/cm(2), 95% CI 0.03 to 0.07; P<0.00001; P for heterogeneity =0.22, I(2)=22%) and subgroup 2 (TC vs conventional treatments; WMD =0.16 g/cm(2), 95% CI 0.11 to 0.21; P<0.00001; P for heterogeneity =0.008, I(2)=75%). In addition, two trials compared TC with conventional treatments, which found a significant difference in bone gla protein (standardized mean difference =−1.18, 95% CI −1.66 to −0.70; P<0.00001; P for heterogeneity =0.58, I(2)=75%). The results of the BMD were confirmed by TSA. Also, TC may have a certain effect on the relief of osteoporotic pain (WMD = −2.61, 95% CI −3.51 to −1.71; WMD = −1.39, 95% CI −2.01 to −0.77). However, it did not promote the quality of life, level of serum calcium, serum phosphorus, and also had no effect on bone turnover markers. CONCLUSION: Although there is no study monitoring fracture incidence, TC may be beneficial for patients in improving BMD values, level of bone gla protein, and relieving osteoporotic pain. However, due to the low methodological quality, current evidence for treating osteopenia and primary osteoporosis through TC is insufficient. Dove Medical Press 2019-01-03 /pmc/articles/PMC6322510/ /pubmed/30655662 http://dx.doi.org/10.2147/CIA.S187588 Text en © 2019 Zhang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Zhang, Yili
Chai, Yan
Pan, Xiaojie
Shen, Hao
Wei, Xu
Xie, Yanming
Tai chi for treating osteopenia and primary osteoporosis: a meta-analysis and trial sequential analysis
title Tai chi for treating osteopenia and primary osteoporosis: a meta-analysis and trial sequential analysis
title_full Tai chi for treating osteopenia and primary osteoporosis: a meta-analysis and trial sequential analysis
title_fullStr Tai chi for treating osteopenia and primary osteoporosis: a meta-analysis and trial sequential analysis
title_full_unstemmed Tai chi for treating osteopenia and primary osteoporosis: a meta-analysis and trial sequential analysis
title_short Tai chi for treating osteopenia and primary osteoporosis: a meta-analysis and trial sequential analysis
title_sort tai chi for treating osteopenia and primary osteoporosis: a meta-analysis and trial sequential analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322510/
https://www.ncbi.nlm.nih.gov/pubmed/30655662
http://dx.doi.org/10.2147/CIA.S187588
work_keys_str_mv AT zhangyili taichifortreatingosteopeniaandprimaryosteoporosisametaanalysisandtrialsequentialanalysis
AT chaiyan taichifortreatingosteopeniaandprimaryosteoporosisametaanalysisandtrialsequentialanalysis
AT panxiaojie taichifortreatingosteopeniaandprimaryosteoporosisametaanalysisandtrialsequentialanalysis
AT shenhao taichifortreatingosteopeniaandprimaryosteoporosisametaanalysisandtrialsequentialanalysis
AT weixu taichifortreatingosteopeniaandprimaryosteoporosisametaanalysisandtrialsequentialanalysis
AT xieyanming taichifortreatingosteopeniaandprimaryosteoporosisametaanalysisandtrialsequentialanalysis