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Non-scarring Alopecias in Iranian Patients: A Histopathological Study With Hair Counts

BACKGROUND AND OBJECTIVE: Non-scarring alopecia is a challenge in the diagnosis and treatment, rarely studied in Asian countries. The current study aimed at evaluating histopathological features including hair count of different subtypes of non-scarring alopecia in Iranian patients. METHODS: The cur...

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Autores principales: Sari Aslani, Fatemeh, Heidari Esfahani, Mina, Sepaskhah, Mozhdeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Society of Pathology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322526/
https://www.ncbi.nlm.nih.gov/pubmed/30636954
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author Sari Aslani, Fatemeh
Heidari Esfahani, Mina
Sepaskhah, Mozhdeh
author_facet Sari Aslani, Fatemeh
Heidari Esfahani, Mina
Sepaskhah, Mozhdeh
author_sort Sari Aslani, Fatemeh
collection PubMed
description BACKGROUND AND OBJECTIVE: Non-scarring alopecia is a challenge in the diagnosis and treatment, rarely studied in Asian countries. The current study aimed at evaluating histopathological features including hair count of different subtypes of non-scarring alopecia in Iranian patients. METHODS: The current study was conducted on 114 cases diagnosed with non-scarring alopecia in Molecular Dermatology Research Center and Pathology Department of Shiraz University of Medical Sciences, Shiraz, Iran. Cases with two 4-mm scalp punch biopsies were selected. Patients’ clinical data were compared with histological findings. RESULTS: Androgenetic alopecia (AGA) was the most common subtype followed by alopecia areata (AA) and combined AGA/telogen effluvium (TE). Perifollicular inflammation was observed in 21% of AGA with a significant difference in males and females (66.7% vs. 33.3%; P-value <0.05). Clinical and histopathologic diagnoses were correlated in 55% of cases. Maximum correlation was observed in combined AGA and chronic TE (88%). For vertical sections, the diagnostic rate was 33.6%, while 88% for transverse sections. CONCLUSION: Transverse together with vertical sectioning provides most of the information in non-scarring alopecias, while transverse sectioning is enough to diagnose the majority of non-scarring alopecias. Perifollicular inflammation was observed in a significant number of cases with AGA, more common in males. It is suggested to report such cases as possibly curable.
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spelling pubmed-63225262019-01-11 Non-scarring Alopecias in Iranian Patients: A Histopathological Study With Hair Counts Sari Aslani, Fatemeh Heidari Esfahani, Mina Sepaskhah, Mozhdeh Iran J Pathol Original Article BACKGROUND AND OBJECTIVE: Non-scarring alopecia is a challenge in the diagnosis and treatment, rarely studied in Asian countries. The current study aimed at evaluating histopathological features including hair count of different subtypes of non-scarring alopecia in Iranian patients. METHODS: The current study was conducted on 114 cases diagnosed with non-scarring alopecia in Molecular Dermatology Research Center and Pathology Department of Shiraz University of Medical Sciences, Shiraz, Iran. Cases with two 4-mm scalp punch biopsies were selected. Patients’ clinical data were compared with histological findings. RESULTS: Androgenetic alopecia (AGA) was the most common subtype followed by alopecia areata (AA) and combined AGA/telogen effluvium (TE). Perifollicular inflammation was observed in 21% of AGA with a significant difference in males and females (66.7% vs. 33.3%; P-value <0.05). Clinical and histopathologic diagnoses were correlated in 55% of cases. Maximum correlation was observed in combined AGA and chronic TE (88%). For vertical sections, the diagnostic rate was 33.6%, while 88% for transverse sections. CONCLUSION: Transverse together with vertical sectioning provides most of the information in non-scarring alopecias, while transverse sectioning is enough to diagnose the majority of non-scarring alopecias. Perifollicular inflammation was observed in a significant number of cases with AGA, more common in males. It is suggested to report such cases as possibly curable. Iranian Society of Pathology 2018 2018-09-12 /pmc/articles/PMC6322526/ /pubmed/30636954 Text en © 2018, IRANIAN JOURNAL OF PATHOLOGY This is an open-access article distributed under the terms of the Creative Commons Attribution-noncommercial 4.0 International License, (https://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Original Article
Sari Aslani, Fatemeh
Heidari Esfahani, Mina
Sepaskhah, Mozhdeh
Non-scarring Alopecias in Iranian Patients: A Histopathological Study With Hair Counts
title Non-scarring Alopecias in Iranian Patients: A Histopathological Study With Hair Counts
title_full Non-scarring Alopecias in Iranian Patients: A Histopathological Study With Hair Counts
title_fullStr Non-scarring Alopecias in Iranian Patients: A Histopathological Study With Hair Counts
title_full_unstemmed Non-scarring Alopecias in Iranian Patients: A Histopathological Study With Hair Counts
title_short Non-scarring Alopecias in Iranian Patients: A Histopathological Study With Hair Counts
title_sort non-scarring alopecias in iranian patients: a histopathological study with hair counts
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322526/
https://www.ncbi.nlm.nih.gov/pubmed/30636954
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