Cargando…
Non-scarring Alopecias in Iranian Patients: A Histopathological Study With Hair Counts
BACKGROUND AND OBJECTIVE: Non-scarring alopecia is a challenge in the diagnosis and treatment, rarely studied in Asian countries. The current study aimed at evaluating histopathological features including hair count of different subtypes of non-scarring alopecia in Iranian patients. METHODS: The cur...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Iranian Society of Pathology
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322526/ https://www.ncbi.nlm.nih.gov/pubmed/30636954 |
_version_ | 1783385623839637504 |
---|---|
author | Sari Aslani, Fatemeh Heidari Esfahani, Mina Sepaskhah, Mozhdeh |
author_facet | Sari Aslani, Fatemeh Heidari Esfahani, Mina Sepaskhah, Mozhdeh |
author_sort | Sari Aslani, Fatemeh |
collection | PubMed |
description | BACKGROUND AND OBJECTIVE: Non-scarring alopecia is a challenge in the diagnosis and treatment, rarely studied in Asian countries. The current study aimed at evaluating histopathological features including hair count of different subtypes of non-scarring alopecia in Iranian patients. METHODS: The current study was conducted on 114 cases diagnosed with non-scarring alopecia in Molecular Dermatology Research Center and Pathology Department of Shiraz University of Medical Sciences, Shiraz, Iran. Cases with two 4-mm scalp punch biopsies were selected. Patients’ clinical data were compared with histological findings. RESULTS: Androgenetic alopecia (AGA) was the most common subtype followed by alopecia areata (AA) and combined AGA/telogen effluvium (TE). Perifollicular inflammation was observed in 21% of AGA with a significant difference in males and females (66.7% vs. 33.3%; P-value <0.05). Clinical and histopathologic diagnoses were correlated in 55% of cases. Maximum correlation was observed in combined AGA and chronic TE (88%). For vertical sections, the diagnostic rate was 33.6%, while 88% for transverse sections. CONCLUSION: Transverse together with vertical sectioning provides most of the information in non-scarring alopecias, while transverse sectioning is enough to diagnose the majority of non-scarring alopecias. Perifollicular inflammation was observed in a significant number of cases with AGA, more common in males. It is suggested to report such cases as possibly curable. |
format | Online Article Text |
id | pubmed-6322526 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Iranian Society of Pathology |
record_format | MEDLINE/PubMed |
spelling | pubmed-63225262019-01-11 Non-scarring Alopecias in Iranian Patients: A Histopathological Study With Hair Counts Sari Aslani, Fatemeh Heidari Esfahani, Mina Sepaskhah, Mozhdeh Iran J Pathol Original Article BACKGROUND AND OBJECTIVE: Non-scarring alopecia is a challenge in the diagnosis and treatment, rarely studied in Asian countries. The current study aimed at evaluating histopathological features including hair count of different subtypes of non-scarring alopecia in Iranian patients. METHODS: The current study was conducted on 114 cases diagnosed with non-scarring alopecia in Molecular Dermatology Research Center and Pathology Department of Shiraz University of Medical Sciences, Shiraz, Iran. Cases with two 4-mm scalp punch biopsies were selected. Patients’ clinical data were compared with histological findings. RESULTS: Androgenetic alopecia (AGA) was the most common subtype followed by alopecia areata (AA) and combined AGA/telogen effluvium (TE). Perifollicular inflammation was observed in 21% of AGA with a significant difference in males and females (66.7% vs. 33.3%; P-value <0.05). Clinical and histopathologic diagnoses were correlated in 55% of cases. Maximum correlation was observed in combined AGA and chronic TE (88%). For vertical sections, the diagnostic rate was 33.6%, while 88% for transverse sections. CONCLUSION: Transverse together with vertical sectioning provides most of the information in non-scarring alopecias, while transverse sectioning is enough to diagnose the majority of non-scarring alopecias. Perifollicular inflammation was observed in a significant number of cases with AGA, more common in males. It is suggested to report such cases as possibly curable. Iranian Society of Pathology 2018 2018-09-12 /pmc/articles/PMC6322526/ /pubmed/30636954 Text en © 2018, IRANIAN JOURNAL OF PATHOLOGY This is an open-access article distributed under the terms of the Creative Commons Attribution-noncommercial 4.0 International License, (https://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited. |
spellingShingle | Original Article Sari Aslani, Fatemeh Heidari Esfahani, Mina Sepaskhah, Mozhdeh Non-scarring Alopecias in Iranian Patients: A Histopathological Study With Hair Counts |
title | Non-scarring Alopecias in Iranian Patients: A Histopathological Study With Hair Counts |
title_full | Non-scarring Alopecias in Iranian Patients: A Histopathological Study With Hair Counts |
title_fullStr | Non-scarring Alopecias in Iranian Patients: A Histopathological Study With Hair Counts |
title_full_unstemmed | Non-scarring Alopecias in Iranian Patients: A Histopathological Study With Hair Counts |
title_short | Non-scarring Alopecias in Iranian Patients: A Histopathological Study With Hair Counts |
title_sort | non-scarring alopecias in iranian patients: a histopathological study with hair counts |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322526/ https://www.ncbi.nlm.nih.gov/pubmed/30636954 |
work_keys_str_mv | AT sariaslanifatemeh nonscarringalopeciasiniranianpatientsahistopathologicalstudywithhaircounts AT heidariesfahanimina nonscarringalopeciasiniranianpatientsahistopathologicalstudywithhaircounts AT sepaskhahmozhdeh nonscarringalopeciasiniranianpatientsahistopathologicalstudywithhaircounts |