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Live-cell super-resolution microscopy reveals a primary role for diffusion in polyglutamine-driven aggresome assembly

The mechanisms leading to self-assembly of misfolded proteins into amyloid aggregates have been studied extensively in the test tube under well-controlled conditions. However, to what extent these processes are representative of those in the cellular environment remains unclear. Using super-resoluti...

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Detalles Bibliográficos
Autores principales:	Lu, Meng, Banetta, Luca, Young, Laurence J., Smith, Edward J., Bates, Gillian P., Zaccone, Alessio, Kaminski Schierle, Gabriele S., Tunnacliffe, Alan, Kaminski, Clemens F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2019
Materias:	Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322900/ https://www.ncbi.nlm.nih.gov/pubmed/30401748 http://dx.doi.org/10.1074/jbc.RA118.003500

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