Cargando…

Cholesterol profile in women with premature menopause after risk reducing salpingo-oophorectomy

This cross-sectional study aimed to investigate the effect of premenopausal risk reducing salpingo-oophorectomy (RRSO) on the cholesterol profile of women at increased ovarian cancer risk and to assess possible effects of age at and time since RRSO. We included 207 women who underwent RRSO before me...

Descripción completa

Detalles Bibliográficos
Autores principales: Teixeira, Natalia, Mourits, Marian J., Oosterwijk, Jan C., Fakkert, Ingrid E., Absalom, Anthony R., Bakker, Stephan J. L., van der Meer, Peter, de Bock, Geertruida H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323069/
https://www.ncbi.nlm.nih.gov/pubmed/29881922
http://dx.doi.org/10.1007/s10689-018-0091-5
_version_ 1783385684347715584
author Teixeira, Natalia
Mourits, Marian J.
Oosterwijk, Jan C.
Fakkert, Ingrid E.
Absalom, Anthony R.
Bakker, Stephan J. L.
van der Meer, Peter
de Bock, Geertruida H.
author_facet Teixeira, Natalia
Mourits, Marian J.
Oosterwijk, Jan C.
Fakkert, Ingrid E.
Absalom, Anthony R.
Bakker, Stephan J. L.
van der Meer, Peter
de Bock, Geertruida H.
author_sort Teixeira, Natalia
collection PubMed
description This cross-sectional study aimed to investigate the effect of premenopausal risk reducing salpingo-oophorectomy (RRSO) on the cholesterol profile of women at increased ovarian cancer risk and to assess possible effects of age at and time since RRSO. We included 207 women who underwent RRSO before menopausal age (52 years) attending the family cancer clinic of an academic hospital and 828 age-matched women from a general population cohort (PREVEND). Participants filled out a questionnaire on socio-demographic characteristics, lifestyle and medical history, had anthropometric measurements and provided blood samples for assessment of serum levels of total cholesterol, HDL-cholesterol and non-HDL-cholesterol. The correlation between RRSO and cholesterol profile was assessed with logistic regression. Furthermore, subgroup analyses were performed to explore a possible effect of age at and time since RRSO. At a median time of 5.9 years (range 2.3–25.2) after surgery, RRSO was associated with low (< 60 mg/dl) HDL-cholesterol (OR 9.74, 95% CI 5.19–18.26) and high (≥ 160 mg/dl) non-HDL-cholesterol (OR 1.85, 95% CI 1.21–2.82) when adjusting for body mass index, hormone therapy, participation on sports and previous chemotherapy. The observed association was not dependent on age or time since RRSO. The RRSO group had less smokers (19.3 vs. 25.8%) and more participation on sports (45.4 vs. 22.0%). Our results suggest that RRSO is associated with a more atherogenic cholesterol profile, despite a lower prevalence of smoking and higher prevalence of participation on sports as compared to controls. This observation can be useful for physicians involved in the counselling and follow-up of women having RRSO.
format Online
Article
Text
id pubmed-6323069
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Springer Netherlands
record_format MEDLINE/PubMed
spelling pubmed-63230692019-01-22 Cholesterol profile in women with premature menopause after risk reducing salpingo-oophorectomy Teixeira, Natalia Mourits, Marian J. Oosterwijk, Jan C. Fakkert, Ingrid E. Absalom, Anthony R. Bakker, Stephan J. L. van der Meer, Peter de Bock, Geertruida H. Fam Cancer Original Article This cross-sectional study aimed to investigate the effect of premenopausal risk reducing salpingo-oophorectomy (RRSO) on the cholesterol profile of women at increased ovarian cancer risk and to assess possible effects of age at and time since RRSO. We included 207 women who underwent RRSO before menopausal age (52 years) attending the family cancer clinic of an academic hospital and 828 age-matched women from a general population cohort (PREVEND). Participants filled out a questionnaire on socio-demographic characteristics, lifestyle and medical history, had anthropometric measurements and provided blood samples for assessment of serum levels of total cholesterol, HDL-cholesterol and non-HDL-cholesterol. The correlation between RRSO and cholesterol profile was assessed with logistic regression. Furthermore, subgroup analyses were performed to explore a possible effect of age at and time since RRSO. At a median time of 5.9 years (range 2.3–25.2) after surgery, RRSO was associated with low (< 60 mg/dl) HDL-cholesterol (OR 9.74, 95% CI 5.19–18.26) and high (≥ 160 mg/dl) non-HDL-cholesterol (OR 1.85, 95% CI 1.21–2.82) when adjusting for body mass index, hormone therapy, participation on sports and previous chemotherapy. The observed association was not dependent on age or time since RRSO. The RRSO group had less smokers (19.3 vs. 25.8%) and more participation on sports (45.4 vs. 22.0%). Our results suggest that RRSO is associated with a more atherogenic cholesterol profile, despite a lower prevalence of smoking and higher prevalence of participation on sports as compared to controls. This observation can be useful for physicians involved in the counselling and follow-up of women having RRSO. Springer Netherlands 2018-06-07 2019 /pmc/articles/PMC6323069/ /pubmed/29881922 http://dx.doi.org/10.1007/s10689-018-0091-5 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Teixeira, Natalia
Mourits, Marian J.
Oosterwijk, Jan C.
Fakkert, Ingrid E.
Absalom, Anthony R.
Bakker, Stephan J. L.
van der Meer, Peter
de Bock, Geertruida H.
Cholesterol profile in women with premature menopause after risk reducing salpingo-oophorectomy
title Cholesterol profile in women with premature menopause after risk reducing salpingo-oophorectomy
title_full Cholesterol profile in women with premature menopause after risk reducing salpingo-oophorectomy
title_fullStr Cholesterol profile in women with premature menopause after risk reducing salpingo-oophorectomy
title_full_unstemmed Cholesterol profile in women with premature menopause after risk reducing salpingo-oophorectomy
title_short Cholesterol profile in women with premature menopause after risk reducing salpingo-oophorectomy
title_sort cholesterol profile in women with premature menopause after risk reducing salpingo-oophorectomy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323069/
https://www.ncbi.nlm.nih.gov/pubmed/29881922
http://dx.doi.org/10.1007/s10689-018-0091-5
work_keys_str_mv AT teixeiranatalia cholesterolprofileinwomenwithprematuremenopauseafterriskreducingsalpingooophorectomy
AT mouritsmarianj cholesterolprofileinwomenwithprematuremenopauseafterriskreducingsalpingooophorectomy
AT oosterwijkjanc cholesterolprofileinwomenwithprematuremenopauseafterriskreducingsalpingooophorectomy
AT fakkertingride cholesterolprofileinwomenwithprematuremenopauseafterriskreducingsalpingooophorectomy
AT absalomanthonyr cholesterolprofileinwomenwithprematuremenopauseafterriskreducingsalpingooophorectomy
AT bakkerstephanjl cholesterolprofileinwomenwithprematuremenopauseafterriskreducingsalpingooophorectomy
AT vandermeerpeter cholesterolprofileinwomenwithprematuremenopauseafterriskreducingsalpingooophorectomy
AT debockgeertruidah cholesterolprofileinwomenwithprematuremenopauseafterriskreducingsalpingooophorectomy