CD200 expression is a feature of solid pseudopapillary neoplasms of the pancreas

CD200 has been recently indicated as a robust marker of well-differentiated neuroendocrine neoplasms. Here, we evaluate its role in differential diagnosis of solid pancreatic neoplasms. We immunostained for CD200 22 solid pseudopapillary neoplasms (SPNs), 8 acinar carcinomas (ACs), 2 pancreatoblasto...

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Autores principales: Lawlor, Rita T., Daprà, Valentina, Girolami, Ilaria, Pea, Antonio, Pilati, Camilla, Nottegar, Alessia, Piccoli, Paola, Parolini, Claudia, Sperandio, Nicola, Capelli, Paola, Scarpa, Aldo, Luchini, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323071/
https://www.ncbi.nlm.nih.gov/pubmed/30132130
http://dx.doi.org/10.1007/s00428-018-2437-7
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author Lawlor, Rita T.
Daprà, Valentina
Girolami, Ilaria
Pea, Antonio
Pilati, Camilla
Nottegar, Alessia
Piccoli, Paola
Parolini, Claudia
Sperandio, Nicola
Capelli, Paola
Scarpa, Aldo
Luchini, Claudio
author_facet Lawlor, Rita T.
Daprà, Valentina
Girolami, Ilaria
Pea, Antonio
Pilati, Camilla
Nottegar, Alessia
Piccoli, Paola
Parolini, Claudia
Sperandio, Nicola
Capelli, Paola
Scarpa, Aldo
Luchini, Claudio
author_sort Lawlor, Rita T.
collection PubMed
description CD200 has been recently indicated as a robust marker of well-differentiated neuroendocrine neoplasms. Here, we evaluate its role in differential diagnosis of solid pancreatic neoplasms. We immunostained for CD200 22 solid pseudopapillary neoplasms (SPNs), 8 acinar carcinomas (ACs), 2 pancreatoblastomas (PBs), 138 neuroendocrine tumors (PanNETs), and 48 ductal adenocarcinomas. All SPNs showed strong cytoplasmic and membranous staining for CD200, while only one case of AC had focal positivity. The two PBs showed focal CD200 positivity, mainly located in squamoid nests. The vast majority of PanNETs (96%) showed strong cytoplasmic and membranous staining for CD200, whereas all PDACs were negative. As both PanNETs and SPNs express CD200, it has no role in the differential diagnosis between these two entities.
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spelling pubmed-63230712019-01-22 CD200 expression is a feature of solid pseudopapillary neoplasms of the pancreas Lawlor, Rita T. Daprà, Valentina Girolami, Ilaria Pea, Antonio Pilati, Camilla Nottegar, Alessia Piccoli, Paola Parolini, Claudia Sperandio, Nicola Capelli, Paola Scarpa, Aldo Luchini, Claudio Virchows Arch Brief Report CD200 has been recently indicated as a robust marker of well-differentiated neuroendocrine neoplasms. Here, we evaluate its role in differential diagnosis of solid pancreatic neoplasms. We immunostained for CD200 22 solid pseudopapillary neoplasms (SPNs), 8 acinar carcinomas (ACs), 2 pancreatoblastomas (PBs), 138 neuroendocrine tumors (PanNETs), and 48 ductal adenocarcinomas. All SPNs showed strong cytoplasmic and membranous staining for CD200, while only one case of AC had focal positivity. The two PBs showed focal CD200 positivity, mainly located in squamoid nests. The vast majority of PanNETs (96%) showed strong cytoplasmic and membranous staining for CD200, whereas all PDACs were negative. As both PanNETs and SPNs express CD200, it has no role in the differential diagnosis between these two entities. Springer Berlin Heidelberg 2018-08-21 2019 /pmc/articles/PMC6323071/ /pubmed/30132130 http://dx.doi.org/10.1007/s00428-018-2437-7 Text en © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Brief Report
Lawlor, Rita T.
Daprà, Valentina
Girolami, Ilaria
Pea, Antonio
Pilati, Camilla
Nottegar, Alessia
Piccoli, Paola
Parolini, Claudia
Sperandio, Nicola
Capelli, Paola
Scarpa, Aldo
Luchini, Claudio
CD200 expression is a feature of solid pseudopapillary neoplasms of the pancreas
title CD200 expression is a feature of solid pseudopapillary neoplasms of the pancreas
title_full CD200 expression is a feature of solid pseudopapillary neoplasms of the pancreas
title_fullStr CD200 expression is a feature of solid pseudopapillary neoplasms of the pancreas
title_full_unstemmed CD200 expression is a feature of solid pseudopapillary neoplasms of the pancreas
title_short CD200 expression is a feature of solid pseudopapillary neoplasms of the pancreas
title_sort cd200 expression is a feature of solid pseudopapillary neoplasms of the pancreas
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323071/
https://www.ncbi.nlm.nih.gov/pubmed/30132130
http://dx.doi.org/10.1007/s00428-018-2437-7
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