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Fate of the Fc fusion protein aflibercept in retinal endothelial cells: competition of recycling and degradation
PURPOSE: Intravitreal injection of the VEGF-binding protein aflibercept is widely used to treat various ocular diseases. In vitro, immortalized bovine retinal endothelial cells (iBREC) take up and transport aflibercept through the cell layer in a serum-dependent manner, likely mediated through the n...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Berlin Heidelberg
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323079/ https://www.ncbi.nlm.nih.gov/pubmed/30367290 http://dx.doi.org/10.1007/s00417-018-4166-7 |