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Analysis across multiple tumor types provides no evidence that mutant p53 exerts dominant negative activity
Missense mutations in the TP53-binding domain predominate, and >30% of these occur in just eight codons. Dominant negative properties of mutant p53, taken together with the mutation susceptibility of the nucleotides in the codon, are believed to explain the prevalence of specific mutations, inclu...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323121/ https://www.ncbi.nlm.nih.gov/pubmed/30623031 http://dx.doi.org/10.1038/s41698-018-0074-x |