Cargando…

Memantine protects thalamocortical hyper‐glutamatergic transmission induced by NMDA receptor antagonism via activation of system xc(−)

Deficiencies in N‐methyl‐d‐aspartate (NMDA)/glutamate receptor (NMDAR) signaling have been considered central to the cognitive impairments of schizophrenia; however, an NMDAR antagonist memantine (MEM) improves cognitive impairments of Alzheimer's disease and schizophrenia. These mechanisms of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Okada, Motohiro, Fukuyama, Kouji, Kawano, Yasuhiro, Shiroyama, Takashi, Ueda, Yuto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323135/ https://www.ncbi.nlm.nih.gov/pubmed/30784207 http://dx.doi.org/10.1002/prp2.457

Ejemplares similares

Chronic Administrations of Guanfacine on Mesocortical Catecholaminergic and Thalamocortical Glutamatergic Transmissions
por: Fukuyama, Kouji, et al.
Publicado: (2021)

Cystine/Glutamate Antiporter and Aripiprazole Compensate NMDA Antagonist-Induced Dysfunction of Thalamocortical L-Glutamatergic Transmission
por: Fukuyama, Kouji, et al.
Publicado: (2018)

Clozapine Normalizes a Glutamatergic Transmission Abnormality Induced by an Impaired NMDA Receptor in the Thalamocortical Pathway via the Activation of a Group III Metabotropic Glutamate Receptor
por: Fukuyama, Kouji, et al.
Publicado: (2019)

Pharmacological Discrimination of Effects of MK801 on Thalamocortical, Mesothalamic, and Mesocortical Transmissions
por: Okada, Motohiro, et al.
Publicado: (2019)

Effects of Subchronic Administrations of Vortioxetine, Lurasidone, and Escitalopram on Thalamocortical Glutamatergic Transmission Associated with Serotonin 5-HT7 Receptor
por: Okada, Motohiro, et al.
Publicado: (2021)

Lurasidone Sub-Chronically Activates Serotonergic Transmission via Desensitization of 5-HT1A and 5-HT7 Receptors in Dorsal Raphe Nucleus
por: Okada, Motohiro, et al.
Publicado: (2019)

Carbamazepine Attenuates Astroglial L-Glutamate Release Induced by Pro-Inflammatory Cytokines via Chronically Activation of Adenosine A(2A) Receptor
por: Okada, Motohiro, et al.
Publicado: (2019)

Interaction between Mesocortical and Mesothalamic Catecholaminergic Transmissions Associated with NMDA Receptor in the Locus Coeruleus
por: Okada, Motohiro, et al.
Publicado: (2020)

Current Limitations and Candidate Potential of 5-HT7 Receptor Antagonism in Psychiatric Pharmacotherapy
por: Okubo, Ruri, et al.
Publicado: (2021)

Amantadine Combines Astroglial System Xc(−) Activation with Glutamate/NMDA Receptor Inhibition
por: Nakano, Tomosuke, et al.
Publicado: (2019)

Candidate Strategies for Development of a Rapid-Acting Antidepressant Class That Does Not Result in Neuropsychiatric Adverse Effects: Prevention of Ketamine-Induced Neuropsychiatric Adverse Reactions
por: Okada, Motohiro, et al.
Publicado: (2020)

Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease
por: Takahashi, Hiroto, et al.
Publicado: (2015)

Corrigendum: Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease
por: Takahashi, Hiroto, et al.
Publicado: (2016)

Effects of Financial Expenditure of Prefectures/Municipalities on Regional Suicide Mortality in Japan
por: Shiroyama, Takashi, et al.
Publicado: (2021)

Distinct Effects of Escitalopram and Vortioxetine on Astroglial L-Glutamate Release Associated with Connexin43
por: Shiroyama, Takashi, et al.
Publicado: (2021)

Effects of Carbamazepine, Lacosamide and Zonisamide on Gliotransmitter Release Associated with Activated Astroglial Hemichannels
por: Fukuyama, Kouji, et al.
Publicado: (2020)

A Working Hypothesis Regarding Identical Pathomechanisms between Clinical Efficacy and Adverse Reaction of Clozapine via the Activation of Connexin43
por: Okada, Motohiro, et al.
Publicado: (2020)

Effects of Atypical Antipsychotics, Clozapine, Quetiapine and Brexpiprazole on Astroglial Transmission Associated with Connexin43
por: Fukuyama, Kouji, et al.
Publicado: (2021)

Activation of Astroglial Connexin Is Involved in Concentration-Dependent Double-Edged Sword Clinical Action of Clozapine
por: Fukuyama, Kouji, et al.
Publicado: (2020)

Determining What Changed Japanese Suicide Mortality in 2020 Using Governmental Database
por: Matsumoto, Ryusuke, et al.
Publicado: (2021)

Astroglial Connexin43 as a Potential Target for a Mood Stabiliser
por: Okada, Motohiro, et al.
Publicado: (2020)

Brexpiprazole Reduces 5-HT7 Receptor Function on Astroglial Transmission Systems
por: Fukuyama, Kouji, et al.
Publicado: (2022)

Glutamatergic Dysbalance and Oxidative Stress in In Vivo and In Vitro Models of Psychosis Based on Chronic NMDA Receptor Antagonism
por: Genius, Just, et al.
Publicado: (2013)

Mechanical and Electronic Properties of XC(6) and XC(12)
por: Wei, Qun, et al.
Publicado: (2016)

Vortioxetine Subchronically Activates Serotonergic Transmission via Desensitization of Serotonin 5-HT(1A) Receptor with 5-HT(3) Receptor Inhibition in Rats
por: Okada, Motohiro, et al.
Publicado: (2019)

Plasticity-Related Gene 1 Affects Mouse Barrel Cortex Function via Strengthening of Glutamatergic Thalamocortical Transmission
por: Unichenko, Petr, et al.
Publicado: (2016)

Is Memantine Effective as an NMDA Receptor Antagonist in Adjunctive Therapy for Schizophrenia?
por: Kikuchi, Tetsuro
Publicado: (2020)

Bidirectional Causality between Spreading COVID-19 and Individual Mobilisation with Consumption Motives across Prefectural Borders in Japan
por: Kawano, Yasuhiro, et al.
Publicado: (2022)

Analyzing the changing relationship between personal consumption and suicide mortality during COVID-19 pandemic in Japan, using governmental and personal consumption transaction databases
por: Matsumoto, Ryusuke, et al.
Publicado: (2022)

New alleles of C. elegans gene cls-2 (R107.6), called xc3, xc4, and xc5
por: Munoz, Nicholas R., et al.
Publicado: (2017)

Galantamine potentiates the neuroprotective effect of memantine against NMDA-induced excitotoxicity
por: Lopes, João P, et al.
Publicado: (2013)

The effect of the NMDA channel blocker memantine on salicylate-induced tinnitus in rats
por: RALLI, M., et al.
Publicado: (2014)

Effects of Memantine, an NMDA Antagonist, on Metabolic Syndromes in Female NMRI Mice
por: Osanloo, Naser, et al.
Publicado: (2015)

Age-Dependent and Sleep/Seizure-Induced Pathomechanisms of Autosomal Dominant Sleep-Related Hypermotor Epilepsy
por: Fukuyama, Kouji, et al.
Publicado: (2020)

Effects of an Atypical Antipsychotic, Zotepine, on Astroglial L-Glutamate Release through Hemichannels: Exploring the Mechanism of Mood-Stabilising Antipsychotic Actions and Antipsychotic-Induced Convulsion
por: Fukuyama, Kouji, et al.
Publicado: (2021)

Brivaracetam and Levetiracetam Suppress Astroglial L-Glutamate Release through Hemichannel via Inhibition of Synaptic Vesicle Protein
por: Fukuyama, Kouji, et al.
Publicado: (2022)

Non-empirical Mixing Coefficient for Hybrid XC Functionals from Analysis of the XC Kernel
por: Moldabekov, Zhandos A., et al.
Publicado: (2023)

The NMDA receptor complex: a multifunctional machine at the glutamatergic synapse
por: Fan, Xuelai, et al.
Publicado: (2014)

The effect of memantine, an antagonist of the NMDA glutamate receptor, in in vitro and in vivo infections by Trypanosoma cruzi
por: Santos Souza, Higo Fernando, et al.
Publicado: (2019)

Upregulated and Hyperactivated Thalamic Connexin 43 Plays Important Roles in Pathomechanisms of Cognitive Impairment and Seizure of Autosomal Dominant Sleep-Related Hypermotor Epilepsy with S284L-Mutant α4 Subunit of Nicotinic ACh Receptor
por: Fukuyama, Kouji, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_7a9puhrrueg9kggtjscp946607