Cargando…
Pivotal prognostic and diagnostic role of the long non-coding RNA colon cancer-associated transcript 1 expression in human cancer
Long non-coding RNAs (lncRNAs) have been classically defined as regulatory RNA members >200 nucleotides in length, without detectable open-reading frames to encode proteins. Previous studies have demonstrated that lncRNAs serve critical roles in multiple cancer types. Colon cancer-associated tran...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323215/ https://www.ncbi.nlm.nih.gov/pubmed/30535444 http://dx.doi.org/10.3892/mmr.2018.9721 |
_version_ | 1783385718168485888 |
---|---|
author | Wang, Ni Yu, Yang Xu, Boming Zhang, Mingjiong Li, Quanpeng Miao, Lin |
author_facet | Wang, Ni Yu, Yang Xu, Boming Zhang, Mingjiong Li, Quanpeng Miao, Lin |
author_sort | Wang, Ni |
collection | PubMed |
description | Long non-coding RNAs (lncRNAs) have been classically defined as regulatory RNA members >200 nucleotides in length, without detectable open-reading frames to encode proteins. Previous studies have demonstrated that lncRNAs serve critical roles in multiple cancer types. Colon cancer-associated transcript 1 (CCAT1), a novel cancer-associated lncRNA, is significantly overexpressed in a number of malignancies. Functionally, as an oncogenic lncRNA, CCAT1 is involved in proliferation, migration, cell cycle progression, apoptosis, chemoresistance and other biological processes of cancer cells through complex regulation mechanisms in the cytoplasm or nucleus. In clinical applications, CCAT1 is additionally positively associated with histological differentiation, tumour node metastasis stage, vascular invasion, overall survival and recurrence-free survival, which demonstrates its important role as a diagnostic and prognostic marker in cancer. The present review summarises the current research progress of the oncogenic potential and clinical uses of CCAT1 in various human cancer types. |
format | Online Article Text |
id | pubmed-6323215 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-63232152019-01-15 Pivotal prognostic and diagnostic role of the long non-coding RNA colon cancer-associated transcript 1 expression in human cancer Wang, Ni Yu, Yang Xu, Boming Zhang, Mingjiong Li, Quanpeng Miao, Lin Mol Med Rep Review Long non-coding RNAs (lncRNAs) have been classically defined as regulatory RNA members >200 nucleotides in length, without detectable open-reading frames to encode proteins. Previous studies have demonstrated that lncRNAs serve critical roles in multiple cancer types. Colon cancer-associated transcript 1 (CCAT1), a novel cancer-associated lncRNA, is significantly overexpressed in a number of malignancies. Functionally, as an oncogenic lncRNA, CCAT1 is involved in proliferation, migration, cell cycle progression, apoptosis, chemoresistance and other biological processes of cancer cells through complex regulation mechanisms in the cytoplasm or nucleus. In clinical applications, CCAT1 is additionally positively associated with histological differentiation, tumour node metastasis stage, vascular invasion, overall survival and recurrence-free survival, which demonstrates its important role as a diagnostic and prognostic marker in cancer. The present review summarises the current research progress of the oncogenic potential and clinical uses of CCAT1 in various human cancer types. D.A. Spandidos 2019-02 2018-12-04 /pmc/articles/PMC6323215/ /pubmed/30535444 http://dx.doi.org/10.3892/mmr.2018.9721 Text en Copyright: © Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review Wang, Ni Yu, Yang Xu, Boming Zhang, Mingjiong Li, Quanpeng Miao, Lin Pivotal prognostic and diagnostic role of the long non-coding RNA colon cancer-associated transcript 1 expression in human cancer |
title | Pivotal prognostic and diagnostic role of the long non-coding RNA colon cancer-associated transcript 1 expression in human cancer |
title_full | Pivotal prognostic and diagnostic role of the long non-coding RNA colon cancer-associated transcript 1 expression in human cancer |
title_fullStr | Pivotal prognostic and diagnostic role of the long non-coding RNA colon cancer-associated transcript 1 expression in human cancer |
title_full_unstemmed | Pivotal prognostic and diagnostic role of the long non-coding RNA colon cancer-associated transcript 1 expression in human cancer |
title_short | Pivotal prognostic and diagnostic role of the long non-coding RNA colon cancer-associated transcript 1 expression in human cancer |
title_sort | pivotal prognostic and diagnostic role of the long non-coding rna colon cancer-associated transcript 1 expression in human cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323215/ https://www.ncbi.nlm.nih.gov/pubmed/30535444 http://dx.doi.org/10.3892/mmr.2018.9721 |
work_keys_str_mv | AT wangni pivotalprognosticanddiagnosticroleofthelongnoncodingrnacoloncancerassociatedtranscript1expressioninhumancancer AT yuyang pivotalprognosticanddiagnosticroleofthelongnoncodingrnacoloncancerassociatedtranscript1expressioninhumancancer AT xuboming pivotalprognosticanddiagnosticroleofthelongnoncodingrnacoloncancerassociatedtranscript1expressioninhumancancer AT zhangmingjiong pivotalprognosticanddiagnosticroleofthelongnoncodingrnacoloncancerassociatedtranscript1expressioninhumancancer AT liquanpeng pivotalprognosticanddiagnosticroleofthelongnoncodingrnacoloncancerassociatedtranscript1expressioninhumancancer AT miaolin pivotalprognosticanddiagnosticroleofthelongnoncodingrnacoloncancerassociatedtranscript1expressioninhumancancer |