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Quantitative Electroencephalography Analyzed by Statistical Pattern Recognition as a Diagnostic and Prognostic Tool in Mild Cognitive Impairment: Results from a Nordic Multicenter Cohort Study
AIM: To examine diagnostic and prognostic potential of quantitative electroencephalography (qEEG) analyzed by the statistical pattern recognition (SPR) method in patients with cognitive impairment. We compared the differential diagnostic ability of SPR to visual EEG analysis. Correlation between SPR...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323395/ https://www.ncbi.nlm.nih.gov/pubmed/30631335 http://dx.doi.org/10.1159/000490788 |
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author | Schjønning Nielsen, Malene Simonsen, Anja Hviid Siersma, Volkert Engedal, Knut Jelic, Vesna Andersen, Birgitte Bo Naik, Mala Hasselbalch, Steen Gregers Høgh, Peter |
author_facet | Schjønning Nielsen, Malene Simonsen, Anja Hviid Siersma, Volkert Engedal, Knut Jelic, Vesna Andersen, Birgitte Bo Naik, Mala Hasselbalch, Steen Gregers Høgh, Peter |
author_sort | Schjønning Nielsen, Malene |
collection | PubMed |
description | AIM: To examine diagnostic and prognostic potential of quantitative electroencephalography (qEEG) analyzed by the statistical pattern recognition (SPR) method in patients with cognitive impairment. We compared the differential diagnostic ability of SPR to visual EEG analysis. Correlation between SPR findings and cerebrospinal fluid (CSF) Alzheimer disease (AD) biomarkers were evaluated. METHODS: It is a multicenter cohort study involving 129 patients, (mild cognitive impairment [MCI], AD, and healthy controls). Standardized EEG was performed at baseline. Patients were continuously clinically evaluated. RESULTS: Receiver Operating Characteristic curves showed a low discriminative ability of SPR and no ability to predict clinical progression in patients with MCI. Moderate correlation between SPR analysis and CSF AD biomarkers was found. CONCLUSION: The diagnostic and prognostic abilities of qEEG were low. The SPR method was superior to the visual EEG analysis. The qEEG method correlates well to CSF AD biomarkers, suggesting association with pathology in AD. |
format | Online Article Text |
id | pubmed-6323395 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-63233952019-01-10 Quantitative Electroencephalography Analyzed by Statistical Pattern Recognition as a Diagnostic and Prognostic Tool in Mild Cognitive Impairment: Results from a Nordic Multicenter Cohort Study Schjønning Nielsen, Malene Simonsen, Anja Hviid Siersma, Volkert Engedal, Knut Jelic, Vesna Andersen, Birgitte Bo Naik, Mala Hasselbalch, Steen Gregers Høgh, Peter Dement Geriatr Cogn Dis Extra Original Research Article AIM: To examine diagnostic and prognostic potential of quantitative electroencephalography (qEEG) analyzed by the statistical pattern recognition (SPR) method in patients with cognitive impairment. We compared the differential diagnostic ability of SPR to visual EEG analysis. Correlation between SPR findings and cerebrospinal fluid (CSF) Alzheimer disease (AD) biomarkers were evaluated. METHODS: It is a multicenter cohort study involving 129 patients, (mild cognitive impairment [MCI], AD, and healthy controls). Standardized EEG was performed at baseline. Patients were continuously clinically evaluated. RESULTS: Receiver Operating Characteristic curves showed a low discriminative ability of SPR and no ability to predict clinical progression in patients with MCI. Moderate correlation between SPR analysis and CSF AD biomarkers was found. CONCLUSION: The diagnostic and prognostic abilities of qEEG were low. The SPR method was superior to the visual EEG analysis. The qEEG method correlates well to CSF AD biomarkers, suggesting association with pathology in AD. S. Karger AG 2018-11-27 /pmc/articles/PMC6323395/ /pubmed/30631335 http://dx.doi.org/10.1159/000490788 Text en Copyright © 2018 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission. |
spellingShingle | Original Research Article Schjønning Nielsen, Malene Simonsen, Anja Hviid Siersma, Volkert Engedal, Knut Jelic, Vesna Andersen, Birgitte Bo Naik, Mala Hasselbalch, Steen Gregers Høgh, Peter Quantitative Electroencephalography Analyzed by Statistical Pattern Recognition as a Diagnostic and Prognostic Tool in Mild Cognitive Impairment: Results from a Nordic Multicenter Cohort Study |
title | Quantitative Electroencephalography Analyzed by Statistical Pattern Recognition as a Diagnostic and Prognostic Tool in Mild Cognitive Impairment: Results from a Nordic Multicenter Cohort Study |
title_full | Quantitative Electroencephalography Analyzed by Statistical Pattern Recognition as a Diagnostic and Prognostic Tool in Mild Cognitive Impairment: Results from a Nordic Multicenter Cohort Study |
title_fullStr | Quantitative Electroencephalography Analyzed by Statistical Pattern Recognition as a Diagnostic and Prognostic Tool in Mild Cognitive Impairment: Results from a Nordic Multicenter Cohort Study |
title_full_unstemmed | Quantitative Electroencephalography Analyzed by Statistical Pattern Recognition as a Diagnostic and Prognostic Tool in Mild Cognitive Impairment: Results from a Nordic Multicenter Cohort Study |
title_short | Quantitative Electroencephalography Analyzed by Statistical Pattern Recognition as a Diagnostic and Prognostic Tool in Mild Cognitive Impairment: Results from a Nordic Multicenter Cohort Study |
title_sort | quantitative electroencephalography analyzed by statistical pattern recognition as a diagnostic and prognostic tool in mild cognitive impairment: results from a nordic multicenter cohort study |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323395/ https://www.ncbi.nlm.nih.gov/pubmed/30631335 http://dx.doi.org/10.1159/000490788 |
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