Advanced Renal Cell Cancer and Low-Dose Palliative Radiation Treatment: A Case of a Substantial and Sustained Treatment Response

Clear cell carcinoma is the most common form of renal cell carcinoma (RCC). Metastatic RCC is poorly responsive to treatment and has a bleak prognosis. Newer systemic agents have improved outcomes. Furthermore, their interaction with radiation treatment (RT) may provide further therapeutic options....

Descripción completa

Detalles Bibliográficos
Autores principales: van Gysen, Kirsten, Kneebone, Andrew, Eade, Thomas, Guminski, Alexander, Hruby, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323401/
https://www.ncbi.nlm.nih.gov/pubmed/30627089
http://dx.doi.org/10.1159/000493913
_version_ 1783385755856404480
author van Gysen, Kirsten
Kneebone, Andrew
Eade, Thomas
Guminski, Alexander
Hruby, George
author_facet van Gysen, Kirsten
Kneebone, Andrew
Eade, Thomas
Guminski, Alexander
Hruby, George
author_sort van Gysen, Kirsten
collection PubMed
description Clear cell carcinoma is the most common form of renal cell carcinoma (RCC). Metastatic RCC is poorly responsive to treatment and has a bleak prognosis. Newer systemic agents have improved outcomes. Furthermore, their interaction with radiation treatment (RT) may provide further therapeutic options. RCC is considered to be radioresistant, however we report the case of a patient with progression on targeted therapy and immunotherapy who achieved a substantial and sustained local, and possibly abscopal, response to low dose palliative radiation therapy.
format Online
Article
Text
id pubmed-6323401
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher S. Karger AG
record_format MEDLINE/PubMed
spelling pubmed-63234012019-01-09 Advanced Renal Cell Cancer and Low-Dose Palliative Radiation Treatment: A Case of a Substantial and Sustained Treatment Response van Gysen, Kirsten Kneebone, Andrew Eade, Thomas Guminski, Alexander Hruby, George Case Rep Oncol Case Report Clear cell carcinoma is the most common form of renal cell carcinoma (RCC). Metastatic RCC is poorly responsive to treatment and has a bleak prognosis. Newer systemic agents have improved outcomes. Furthermore, their interaction with radiation treatment (RT) may provide further therapeutic options. RCC is considered to be radioresistant, however we report the case of a patient with progression on targeted therapy and immunotherapy who achieved a substantial and sustained local, and possibly abscopal, response to low dose palliative radiation therapy. S. Karger AG 2018-11-27 /pmc/articles/PMC6323401/ /pubmed/30627089 http://dx.doi.org/10.1159/000493913 Text en Copyright © 2018 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
van Gysen, Kirsten
Kneebone, Andrew
Eade, Thomas
Guminski, Alexander
Hruby, George
Advanced Renal Cell Cancer and Low-Dose Palliative Radiation Treatment: A Case of a Substantial and Sustained Treatment Response
title Advanced Renal Cell Cancer and Low-Dose Palliative Radiation Treatment: A Case of a Substantial and Sustained Treatment Response
title_full Advanced Renal Cell Cancer and Low-Dose Palliative Radiation Treatment: A Case of a Substantial and Sustained Treatment Response
title_fullStr Advanced Renal Cell Cancer and Low-Dose Palliative Radiation Treatment: A Case of a Substantial and Sustained Treatment Response
title_full_unstemmed Advanced Renal Cell Cancer and Low-Dose Palliative Radiation Treatment: A Case of a Substantial and Sustained Treatment Response
title_short Advanced Renal Cell Cancer and Low-Dose Palliative Radiation Treatment: A Case of a Substantial and Sustained Treatment Response
title_sort advanced renal cell cancer and low-dose palliative radiation treatment: a case of a substantial and sustained treatment response
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323401/
https://www.ncbi.nlm.nih.gov/pubmed/30627089
http://dx.doi.org/10.1159/000493913
work_keys_str_mv AT vangysenkirsten advancedrenalcellcancerandlowdosepalliativeradiationtreatmentacaseofasubstantialandsustainedtreatmentresponse
AT kneeboneandrew advancedrenalcellcancerandlowdosepalliativeradiationtreatmentacaseofasubstantialandsustainedtreatmentresponse
AT eadethomas advancedrenalcellcancerandlowdosepalliativeradiationtreatmentacaseofasubstantialandsustainedtreatmentresponse
AT guminskialexander advancedrenalcellcancerandlowdosepalliativeradiationtreatmentacaseofasubstantialandsustainedtreatmentresponse
AT hrubygeorge advancedrenalcellcancerandlowdosepalliativeradiationtreatmentacaseofasubstantialandsustainedtreatmentresponse

Ejemplares similares