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The Role of Imaging in Measuring Disease Progression and Assessing Novel Therapies in Aortic Stenosis
Aortic stenosis represents a growing health care burden in high-income countries. Currently, the only definitive treatment is surgical or transcatheter valve intervention at the end stages of disease. As the understanding of the underlying pathophysiology evolves, many promising therapies are being...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323414/ https://www.ncbi.nlm.nih.gov/pubmed/30621990 http://dx.doi.org/10.1016/j.jcmg.2018.10.023 |
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author | Doris, Mhairi K. Everett, Russell J. Shun-Shin, Matthew Clavel, Marie-Annick Dweck, Marc R. |
author_facet | Doris, Mhairi K. Everett, Russell J. Shun-Shin, Matthew Clavel, Marie-Annick Dweck, Marc R. |
author_sort | Doris, Mhairi K. |
collection | PubMed |
description | Aortic stenosis represents a growing health care burden in high-income countries. Currently, the only definitive treatment is surgical or transcatheter valve intervention at the end stages of disease. As the understanding of the underlying pathophysiology evolves, many promising therapies are being investigated. These seek to both slow disease progression in the valve and delay the transition from hypertrophy to heart failure in the myocardium, with the ultimate aim of avoiding the need for valve replacement in the elderly patients afflicted by this condition. Noninvasive imaging has played a pivotal role in enhancing our understanding of the complex pathophysiology underlying aortic stenosis, as well as disease progression in both the valve and myocardium. In this review, the authors discuss the means by which contemporary imaging may be used to assess disease progression and how these approaches may be utilized, both in clinical practice and research trials exploring the clinical efficacy of novel therapies. |
format | Online Article Text |
id | pubmed-6323414 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-63234142019-01-18 The Role of Imaging in Measuring Disease Progression and Assessing Novel Therapies in Aortic Stenosis Doris, Mhairi K. Everett, Russell J. Shun-Shin, Matthew Clavel, Marie-Annick Dweck, Marc R. JACC Cardiovasc Imaging Article Aortic stenosis represents a growing health care burden in high-income countries. Currently, the only definitive treatment is surgical or transcatheter valve intervention at the end stages of disease. As the understanding of the underlying pathophysiology evolves, many promising therapies are being investigated. These seek to both slow disease progression in the valve and delay the transition from hypertrophy to heart failure in the myocardium, with the ultimate aim of avoiding the need for valve replacement in the elderly patients afflicted by this condition. Noninvasive imaging has played a pivotal role in enhancing our understanding of the complex pathophysiology underlying aortic stenosis, as well as disease progression in both the valve and myocardium. In this review, the authors discuss the means by which contemporary imaging may be used to assess disease progression and how these approaches may be utilized, both in clinical practice and research trials exploring the clinical efficacy of novel therapies. Elsevier 2019-01 /pmc/articles/PMC6323414/ /pubmed/30621990 http://dx.doi.org/10.1016/j.jcmg.2018.10.023 Text en © The Authors. Published by Elsevier Inc. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Doris, Mhairi K. Everett, Russell J. Shun-Shin, Matthew Clavel, Marie-Annick Dweck, Marc R. The Role of Imaging in Measuring Disease Progression and Assessing Novel Therapies in Aortic Stenosis |
title | The Role of Imaging in Measuring Disease Progression and Assessing Novel Therapies in Aortic Stenosis |
title_full | The Role of Imaging in Measuring Disease Progression and Assessing Novel Therapies in Aortic Stenosis |
title_fullStr | The Role of Imaging in Measuring Disease Progression and Assessing Novel Therapies in Aortic Stenosis |
title_full_unstemmed | The Role of Imaging in Measuring Disease Progression and Assessing Novel Therapies in Aortic Stenosis |
title_short | The Role of Imaging in Measuring Disease Progression and Assessing Novel Therapies in Aortic Stenosis |
title_sort | role of imaging in measuring disease progression and assessing novel therapies in aortic stenosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323414/ https://www.ncbi.nlm.nih.gov/pubmed/30621990 http://dx.doi.org/10.1016/j.jcmg.2018.10.023 |
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