Pharmacological Inhibition of Caspase-1 Ameliorates Cisplatin-Induced Nephrotoxicity through Suppression of Apoptosis, Oxidative Stress, and Inflammation in Mice

Caspase-1 is a proinflammatory caspase responsible for the proteolytic conversion of the precursor forms of interleukin-1β to its active form and plays an important role in the pathogenesis of various inflammatory diseases. It was reported that genetic deficiency of caspase-1 prevented cisplatin-ind...

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Detalles Bibliográficos
Autores principales: Kim, Jung-Yeon, Park, Jae-Hyung, Kim, Kiryeong, Jo, Jungmin, Leem, Jaechan, Park, Kwan-Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323438/
https://www.ncbi.nlm.nih.gov/pubmed/30670928
http://dx.doi.org/10.1155/2018/6571676

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