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Autoimmune hepatitis: Appraisal of current treatment guidelines
Autoimmune hepatitis affects patients of all ages and gender, across all geographic regions. Although still rare, its incidence and prevalence are increasing. Genetic predisposition conveyed by human leucocyte antigen is a strong risk factor for the disease and may be responsible in part for the wid...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323516/ https://www.ncbi.nlm.nih.gov/pubmed/30631396 http://dx.doi.org/10.4254/wjh.v10.i12.911 |
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author | Lowe, Dhruv John, Savio |
author_facet | Lowe, Dhruv John, Savio |
author_sort | Lowe, Dhruv |
collection | PubMed |
description | Autoimmune hepatitis affects patients of all ages and gender, across all geographic regions. Although still rare, its incidence and prevalence are increasing. Genetic predisposition conveyed by human leucocyte antigen is a strong risk factor for the disease and may be responsible in part for the wide variation in presentation in different geographic regions. Our understanding of the underlying pathogenic mechanisms is evolving and may lead to development of more targeted immunotherapies. Diagnosis is based on elevated levels of serum aminotransferases, gamma globulins, autoantibodies and characteristic findings on histology. Exclusion of other causes of chronic hepatitis is important. Although undiagnosed disease is associated with poor outcomes, it is readily treatable with timely immunosuppressive therapy in the majority of patients. International guidelines are available to guide management but there exists a disparity in the standard treatment regimens. This minireview aims to review the available guidelines and summarize the key recommendations involved in management of this complex autoimmune disease. |
format | Online Article Text |
id | pubmed-6323516 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-63235162019-01-10 Autoimmune hepatitis: Appraisal of current treatment guidelines Lowe, Dhruv John, Savio World J Hepatol Minireviews Autoimmune hepatitis affects patients of all ages and gender, across all geographic regions. Although still rare, its incidence and prevalence are increasing. Genetic predisposition conveyed by human leucocyte antigen is a strong risk factor for the disease and may be responsible in part for the wide variation in presentation in different geographic regions. Our understanding of the underlying pathogenic mechanisms is evolving and may lead to development of more targeted immunotherapies. Diagnosis is based on elevated levels of serum aminotransferases, gamma globulins, autoantibodies and characteristic findings on histology. Exclusion of other causes of chronic hepatitis is important. Although undiagnosed disease is associated with poor outcomes, it is readily treatable with timely immunosuppressive therapy in the majority of patients. International guidelines are available to guide management but there exists a disparity in the standard treatment regimens. This minireview aims to review the available guidelines and summarize the key recommendations involved in management of this complex autoimmune disease. Baishideng Publishing Group Inc 2018-12-27 2018-12-27 /pmc/articles/PMC6323516/ /pubmed/30631396 http://dx.doi.org/10.4254/wjh.v10.i12.911 Text en ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Minireviews Lowe, Dhruv John, Savio Autoimmune hepatitis: Appraisal of current treatment guidelines |
title | Autoimmune hepatitis: Appraisal of current treatment guidelines |
title_full | Autoimmune hepatitis: Appraisal of current treatment guidelines |
title_fullStr | Autoimmune hepatitis: Appraisal of current treatment guidelines |
title_full_unstemmed | Autoimmune hepatitis: Appraisal of current treatment guidelines |
title_short | Autoimmune hepatitis: Appraisal of current treatment guidelines |
title_sort | autoimmune hepatitis: appraisal of current treatment guidelines |
topic | Minireviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323516/ https://www.ncbi.nlm.nih.gov/pubmed/30631396 http://dx.doi.org/10.4254/wjh.v10.i12.911 |
work_keys_str_mv | AT lowedhruv autoimmunehepatitisappraisalofcurrenttreatmentguidelines AT johnsavio autoimmunehepatitisappraisalofcurrenttreatmentguidelines |