Cargando…

THE EFFECT OF ILEOCECAL VALVE REMOVAL IN A MODEL OF SHORT BOWEL SYNDROME

BACKGROUND: Short bowel syndrome is a harmful condition that needs experimental research. AIM: To assess the impact of the ileocecal valve removal in a model of short bowel syndrome, in order to investigate the evolution of the colon under this circumstance. METHOD: Fifteen Wistar rats were equitabl...

Descripción completa

Detalles Bibliográficos
Autores principales: SOLER, Wangles Vasconcellos, LEE, Andre Dong, D’ALBUQUERQUE, Eugênia Machado Carneiro, CAPELOZZI, Vera, ALBUQUERQUE, Luiz Carneiro, CAPELHUCHNICK, Peretz, LANCELOTTI, Carmem Penteado, GALVÃO, Flavio Henrique Ferreira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Colégio Brasileiro de Cirurgia Digestiva 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323627/
https://www.ncbi.nlm.nih.gov/pubmed/30624526
http://dx.doi.org/10.1590/0102-672020180001e1417
_version_ 1783385802973118464
author SOLER, Wangles Vasconcellos
LEE, Andre Dong
D’ALBUQUERQUE, Eugênia Machado Carneiro
CAPELOZZI, Vera
ALBUQUERQUE, Luiz Carneiro
CAPELHUCHNICK, Peretz
LANCELOTTI, Carmem Penteado
GALVÃO, Flavio Henrique Ferreira
author_facet SOLER, Wangles Vasconcellos
LEE, Andre Dong
D’ALBUQUERQUE, Eugênia Machado Carneiro
CAPELOZZI, Vera
ALBUQUERQUE, Luiz Carneiro
CAPELHUCHNICK, Peretz
LANCELOTTI, Carmem Penteado
GALVÃO, Flavio Henrique Ferreira
author_sort SOLER, Wangles Vasconcellos
collection PubMed
description BACKGROUND: Short bowel syndrome is a harmful condition that needs experimental research. AIM: To assess the impact of the ileocecal valve removal in a model of short bowel syndrome, in order to investigate the evolution of the colon under this circumstance. METHOD: Fifteen Wistar rats were equitable divided into: Control (Sham), Group I (70% enterectomy preserving ileocecal valve) and Group II (70% enterectomy excluding ileocecal valve). After enterectomy was performed jejunoileal or jejunocecal anastomosis and sacrificed the animals on 30(th) postoperative day for histomorphometric study of the colon. During this period, was observed the clinical evolution of the animals weekly including body weight measurement. RESULTS: Group I and II presented progressive loss of weight. In Group I was observed diarrhea, perineal hyperemia and purple color of the colon during autopsy. Histomorphometry assay showed hypertrophy and hyperplasia of colon mucosa in Group I. In Group II the colon wall was thicker due to hypertrophy and muscular hyperplasia, and in mucosa vascular proliferation and inflammatory infiltrate were intense. CONCLUSION: This short bowel syndrome model is relevant and achieve 100% of survival. Animal’s weight loss was not altered by the presence or exclusion of the ileocecal valve. Animals with 70% of small bowel removal and presence of the ileocecal valve attained a better clinical evolution and histological colon adaptation than those without ileocecal valve.
format Online
Article
Text
id pubmed-6323627
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Colégio Brasileiro de Cirurgia Digestiva
record_format MEDLINE/PubMed
spelling pubmed-63236272019-01-14 THE EFFECT OF ILEOCECAL VALVE REMOVAL IN A MODEL OF SHORT BOWEL SYNDROME SOLER, Wangles Vasconcellos LEE, Andre Dong D’ALBUQUERQUE, Eugênia Machado Carneiro CAPELOZZI, Vera ALBUQUERQUE, Luiz Carneiro CAPELHUCHNICK, Peretz LANCELOTTI, Carmem Penteado GALVÃO, Flavio Henrique Ferreira Arq Bras Cir Dig Original Article BACKGROUND: Short bowel syndrome is a harmful condition that needs experimental research. AIM: To assess the impact of the ileocecal valve removal in a model of short bowel syndrome, in order to investigate the evolution of the colon under this circumstance. METHOD: Fifteen Wistar rats were equitable divided into: Control (Sham), Group I (70% enterectomy preserving ileocecal valve) and Group II (70% enterectomy excluding ileocecal valve). After enterectomy was performed jejunoileal or jejunocecal anastomosis and sacrificed the animals on 30(th) postoperative day for histomorphometric study of the colon. During this period, was observed the clinical evolution of the animals weekly including body weight measurement. RESULTS: Group I and II presented progressive loss of weight. In Group I was observed diarrhea, perineal hyperemia and purple color of the colon during autopsy. Histomorphometry assay showed hypertrophy and hyperplasia of colon mucosa in Group I. In Group II the colon wall was thicker due to hypertrophy and muscular hyperplasia, and in mucosa vascular proliferation and inflammatory infiltrate were intense. CONCLUSION: This short bowel syndrome model is relevant and achieve 100% of survival. Animal’s weight loss was not altered by the presence or exclusion of the ileocecal valve. Animals with 70% of small bowel removal and presence of the ileocecal valve attained a better clinical evolution and histological colon adaptation than those without ileocecal valve. Colégio Brasileiro de Cirurgia Digestiva 2019-01-07 /pmc/articles/PMC6323627/ /pubmed/30624526 http://dx.doi.org/10.1590/0102-672020180001e1417 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Original Article
SOLER, Wangles Vasconcellos
LEE, Andre Dong
D’ALBUQUERQUE, Eugênia Machado Carneiro
CAPELOZZI, Vera
ALBUQUERQUE, Luiz Carneiro
CAPELHUCHNICK, Peretz
LANCELOTTI, Carmem Penteado
GALVÃO, Flavio Henrique Ferreira
THE EFFECT OF ILEOCECAL VALVE REMOVAL IN A MODEL OF SHORT BOWEL SYNDROME
title THE EFFECT OF ILEOCECAL VALVE REMOVAL IN A MODEL OF SHORT BOWEL SYNDROME
title_full THE EFFECT OF ILEOCECAL VALVE REMOVAL IN A MODEL OF SHORT BOWEL SYNDROME
title_fullStr THE EFFECT OF ILEOCECAL VALVE REMOVAL IN A MODEL OF SHORT BOWEL SYNDROME
title_full_unstemmed THE EFFECT OF ILEOCECAL VALVE REMOVAL IN A MODEL OF SHORT BOWEL SYNDROME
title_short THE EFFECT OF ILEOCECAL VALVE REMOVAL IN A MODEL OF SHORT BOWEL SYNDROME
title_sort effect of ileocecal valve removal in a model of short bowel syndrome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323627/
https://www.ncbi.nlm.nih.gov/pubmed/30624526
http://dx.doi.org/10.1590/0102-672020180001e1417
work_keys_str_mv AT solerwanglesvasconcellos theeffectofileocecalvalveremovalinamodelofshortbowelsyndrome
AT leeandredong theeffectofileocecalvalveremovalinamodelofshortbowelsyndrome
AT dalbuquerqueeugeniamachadocarneiro theeffectofileocecalvalveremovalinamodelofshortbowelsyndrome
AT capelozzivera theeffectofileocecalvalveremovalinamodelofshortbowelsyndrome
AT albuquerqueluizcarneiro theeffectofileocecalvalveremovalinamodelofshortbowelsyndrome
AT capelhuchnickperetz theeffectofileocecalvalveremovalinamodelofshortbowelsyndrome
AT lancelotticarmempenteado theeffectofileocecalvalveremovalinamodelofshortbowelsyndrome
AT galvaoflaviohenriqueferreira theeffectofileocecalvalveremovalinamodelofshortbowelsyndrome
AT solerwanglesvasconcellos effectofileocecalvalveremovalinamodelofshortbowelsyndrome
AT leeandredong effectofileocecalvalveremovalinamodelofshortbowelsyndrome
AT dalbuquerqueeugeniamachadocarneiro effectofileocecalvalveremovalinamodelofshortbowelsyndrome
AT capelozzivera effectofileocecalvalveremovalinamodelofshortbowelsyndrome
AT albuquerqueluizcarneiro effectofileocecalvalveremovalinamodelofshortbowelsyndrome
AT capelhuchnickperetz effectofileocecalvalveremovalinamodelofshortbowelsyndrome
AT lancelotticarmempenteado effectofileocecalvalveremovalinamodelofshortbowelsyndrome
AT galvaoflaviohenriqueferreira effectofileocecalvalveremovalinamodelofshortbowelsyndrome