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THE EFFECT OF ILEOCECAL VALVE REMOVAL IN A MODEL OF SHORT BOWEL SYNDROME
BACKGROUND: Short bowel syndrome is a harmful condition that needs experimental research. AIM: To assess the impact of the ileocecal valve removal in a model of short bowel syndrome, in order to investigate the evolution of the colon under this circumstance. METHOD: Fifteen Wistar rats were equitabl...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Colégio Brasileiro de Cirurgia Digestiva
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323627/ https://www.ncbi.nlm.nih.gov/pubmed/30624526 http://dx.doi.org/10.1590/0102-672020180001e1417 |
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author | SOLER, Wangles Vasconcellos LEE, Andre Dong D’ALBUQUERQUE, Eugênia Machado Carneiro CAPELOZZI, Vera ALBUQUERQUE, Luiz Carneiro CAPELHUCHNICK, Peretz LANCELOTTI, Carmem Penteado GALVÃO, Flavio Henrique Ferreira |
author_facet | SOLER, Wangles Vasconcellos LEE, Andre Dong D’ALBUQUERQUE, Eugênia Machado Carneiro CAPELOZZI, Vera ALBUQUERQUE, Luiz Carneiro CAPELHUCHNICK, Peretz LANCELOTTI, Carmem Penteado GALVÃO, Flavio Henrique Ferreira |
author_sort | SOLER, Wangles Vasconcellos |
collection | PubMed |
description | BACKGROUND: Short bowel syndrome is a harmful condition that needs experimental research. AIM: To assess the impact of the ileocecal valve removal in a model of short bowel syndrome, in order to investigate the evolution of the colon under this circumstance. METHOD: Fifteen Wistar rats were equitable divided into: Control (Sham), Group I (70% enterectomy preserving ileocecal valve) and Group II (70% enterectomy excluding ileocecal valve). After enterectomy was performed jejunoileal or jejunocecal anastomosis and sacrificed the animals on 30(th) postoperative day for histomorphometric study of the colon. During this period, was observed the clinical evolution of the animals weekly including body weight measurement. RESULTS: Group I and II presented progressive loss of weight. In Group I was observed diarrhea, perineal hyperemia and purple color of the colon during autopsy. Histomorphometry assay showed hypertrophy and hyperplasia of colon mucosa in Group I. In Group II the colon wall was thicker due to hypertrophy and muscular hyperplasia, and in mucosa vascular proliferation and inflammatory infiltrate were intense. CONCLUSION: This short bowel syndrome model is relevant and achieve 100% of survival. Animal’s weight loss was not altered by the presence or exclusion of the ileocecal valve. Animals with 70% of small bowel removal and presence of the ileocecal valve attained a better clinical evolution and histological colon adaptation than those without ileocecal valve. |
format | Online Article Text |
id | pubmed-6323627 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Colégio Brasileiro de Cirurgia Digestiva |
record_format | MEDLINE/PubMed |
spelling | pubmed-63236272019-01-14 THE EFFECT OF ILEOCECAL VALVE REMOVAL IN A MODEL OF SHORT BOWEL SYNDROME SOLER, Wangles Vasconcellos LEE, Andre Dong D’ALBUQUERQUE, Eugênia Machado Carneiro CAPELOZZI, Vera ALBUQUERQUE, Luiz Carneiro CAPELHUCHNICK, Peretz LANCELOTTI, Carmem Penteado GALVÃO, Flavio Henrique Ferreira Arq Bras Cir Dig Original Article BACKGROUND: Short bowel syndrome is a harmful condition that needs experimental research. AIM: To assess the impact of the ileocecal valve removal in a model of short bowel syndrome, in order to investigate the evolution of the colon under this circumstance. METHOD: Fifteen Wistar rats were equitable divided into: Control (Sham), Group I (70% enterectomy preserving ileocecal valve) and Group II (70% enterectomy excluding ileocecal valve). After enterectomy was performed jejunoileal or jejunocecal anastomosis and sacrificed the animals on 30(th) postoperative day for histomorphometric study of the colon. During this period, was observed the clinical evolution of the animals weekly including body weight measurement. RESULTS: Group I and II presented progressive loss of weight. In Group I was observed diarrhea, perineal hyperemia and purple color of the colon during autopsy. Histomorphometry assay showed hypertrophy and hyperplasia of colon mucosa in Group I. In Group II the colon wall was thicker due to hypertrophy and muscular hyperplasia, and in mucosa vascular proliferation and inflammatory infiltrate were intense. CONCLUSION: This short bowel syndrome model is relevant and achieve 100% of survival. Animal’s weight loss was not altered by the presence or exclusion of the ileocecal valve. Animals with 70% of small bowel removal and presence of the ileocecal valve attained a better clinical evolution and histological colon adaptation than those without ileocecal valve. Colégio Brasileiro de Cirurgia Digestiva 2019-01-07 /pmc/articles/PMC6323627/ /pubmed/30624526 http://dx.doi.org/10.1590/0102-672020180001e1417 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License |
spellingShingle | Original Article SOLER, Wangles Vasconcellos LEE, Andre Dong D’ALBUQUERQUE, Eugênia Machado Carneiro CAPELOZZI, Vera ALBUQUERQUE, Luiz Carneiro CAPELHUCHNICK, Peretz LANCELOTTI, Carmem Penteado GALVÃO, Flavio Henrique Ferreira THE EFFECT OF ILEOCECAL VALVE REMOVAL IN A MODEL OF SHORT BOWEL SYNDROME |
title | THE EFFECT OF ILEOCECAL VALVE REMOVAL IN A MODEL OF SHORT BOWEL SYNDROME |
title_full | THE EFFECT OF ILEOCECAL VALVE REMOVAL IN A MODEL OF SHORT BOWEL SYNDROME |
title_fullStr | THE EFFECT OF ILEOCECAL VALVE REMOVAL IN A MODEL OF SHORT BOWEL SYNDROME |
title_full_unstemmed | THE EFFECT OF ILEOCECAL VALVE REMOVAL IN A MODEL OF SHORT BOWEL SYNDROME |
title_short | THE EFFECT OF ILEOCECAL VALVE REMOVAL IN A MODEL OF SHORT BOWEL SYNDROME |
title_sort | effect of ileocecal valve removal in a model of short bowel syndrome |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323627/ https://www.ncbi.nlm.nih.gov/pubmed/30624526 http://dx.doi.org/10.1590/0102-672020180001e1417 |
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