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Feasibility of low radiation dose retrospectively-gated cardiac CT for functional analysis in adult congenital heart disease

BACKGROUND: The use of cardiac computed tomography (CT) in the evaluation of adult congenital heart disease patients is limited due to concerns of high radiation doses. The purpose of this study was to prospectively assess whether low radiation dose cardiac CT is feasible to evaluate ventricular sys...

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Autores principales: Groves, Daniel W., Olivieri, Laura J., Shanbhag, Sujata M., Bronson, Kathie C., Yu, Jeannie H., Nelson, Evan A., Rollison, Shirley F., Stagliano, Michael S., John, Anitha S., Kuehl, Karen, Chen, Marcus Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323633/
https://www.ncbi.nlm.nih.gov/pubmed/27865183
http://dx.doi.org/10.1016/j.ijcard.2016.11.108
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author Groves, Daniel W.
Olivieri, Laura J.
Shanbhag, Sujata M.
Bronson, Kathie C.
Yu, Jeannie H.
Nelson, Evan A.
Rollison, Shirley F.
Stagliano, Michael S.
John, Anitha S.
Kuehl, Karen
Chen, Marcus Y.
author_facet Groves, Daniel W.
Olivieri, Laura J.
Shanbhag, Sujata M.
Bronson, Kathie C.
Yu, Jeannie H.
Nelson, Evan A.
Rollison, Shirley F.
Stagliano, Michael S.
John, Anitha S.
Kuehl, Karen
Chen, Marcus Y.
author_sort Groves, Daniel W.
collection PubMed
description BACKGROUND: The use of cardiac computed tomography (CT) in the evaluation of adult congenital heart disease patients is limited due to concerns of high radiation doses. The purpose of this study was to prospectively assess whether low radiation dose cardiac CT is feasible to evaluate ventricular systolic function in adults with congenital heart disease. METHODS: The study group included 30 consecutive patients with significant congenital heart disease who underwent a total of 35 ECG-gated cardiac CT scans utilizing a 320-detector row CT scanner. Each study included a non-contrast scan and subsequent contrast-enhanced retrospectively-gated acquisition. Effective radiation dose was estimated by multiplying the dose length product by a k-factor of 0.014 mSv/mGy cm. RESULTS: The mean age of the patients was 34.4 ± 8.9 years, 60% were men, and mean body mass index was 24.2 ± 4.3 kg/m(2). A majority of patients (n = 28, 93.3%) had contraindications to cardiac MRI. A tube potential of 80 kV was used in 27 (77.1%) of the contrast-enhanced scans. The mean signal-to-noise and contrast-to-noise ratios were 11.5 ± 3.9 and 10.3 ± 3.7, respectively. The median radiation dose for non-contrast and contrast-enhanced images were 0.1 mSv (0.07–0.2 mSv) and 0.94 mSv (0.5–2.1 mSv), respectively. All 35 CT scans were successfully analyzed for ventricular systolic function. CONCLUSIONS: A low radiation contrast-enhanced, retrospectively-gated cardiac CT with a median radiation dose of less than 1 mSv was successful in evaluating ventricular systolic function in 30 consecutive adult congenital heart disease patients who underwent a total of 35 scans.
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spelling pubmed-63236332019-01-08 Feasibility of low radiation dose retrospectively-gated cardiac CT for functional analysis in adult congenital heart disease Groves, Daniel W. Olivieri, Laura J. Shanbhag, Sujata M. Bronson, Kathie C. Yu, Jeannie H. Nelson, Evan A. Rollison, Shirley F. Stagliano, Michael S. John, Anitha S. Kuehl, Karen Chen, Marcus Y. Int J Cardiol Article BACKGROUND: The use of cardiac computed tomography (CT) in the evaluation of adult congenital heart disease patients is limited due to concerns of high radiation doses. The purpose of this study was to prospectively assess whether low radiation dose cardiac CT is feasible to evaluate ventricular systolic function in adults with congenital heart disease. METHODS: The study group included 30 consecutive patients with significant congenital heart disease who underwent a total of 35 ECG-gated cardiac CT scans utilizing a 320-detector row CT scanner. Each study included a non-contrast scan and subsequent contrast-enhanced retrospectively-gated acquisition. Effective radiation dose was estimated by multiplying the dose length product by a k-factor of 0.014 mSv/mGy cm. RESULTS: The mean age of the patients was 34.4 ± 8.9 years, 60% were men, and mean body mass index was 24.2 ± 4.3 kg/m(2). A majority of patients (n = 28, 93.3%) had contraindications to cardiac MRI. A tube potential of 80 kV was used in 27 (77.1%) of the contrast-enhanced scans. The mean signal-to-noise and contrast-to-noise ratios were 11.5 ± 3.9 and 10.3 ± 3.7, respectively. The median radiation dose for non-contrast and contrast-enhanced images were 0.1 mSv (0.07–0.2 mSv) and 0.94 mSv (0.5–2.1 mSv), respectively. All 35 CT scans were successfully analyzed for ventricular systolic function. CONCLUSIONS: A low radiation contrast-enhanced, retrospectively-gated cardiac CT with a median radiation dose of less than 1 mSv was successful in evaluating ventricular systolic function in 30 consecutive adult congenital heart disease patients who underwent a total of 35 scans. 2016-11-09 2017-02-01 /pmc/articles/PMC6323633/ /pubmed/27865183 http://dx.doi.org/10.1016/j.ijcard.2016.11.108 Text en This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Groves, Daniel W.
Olivieri, Laura J.
Shanbhag, Sujata M.
Bronson, Kathie C.
Yu, Jeannie H.
Nelson, Evan A.
Rollison, Shirley F.
Stagliano, Michael S.
John, Anitha S.
Kuehl, Karen
Chen, Marcus Y.
Feasibility of low radiation dose retrospectively-gated cardiac CT for functional analysis in adult congenital heart disease
title Feasibility of low radiation dose retrospectively-gated cardiac CT for functional analysis in adult congenital heart disease
title_full Feasibility of low radiation dose retrospectively-gated cardiac CT for functional analysis in adult congenital heart disease
title_fullStr Feasibility of low radiation dose retrospectively-gated cardiac CT for functional analysis in adult congenital heart disease
title_full_unstemmed Feasibility of low radiation dose retrospectively-gated cardiac CT for functional analysis in adult congenital heart disease
title_short Feasibility of low radiation dose retrospectively-gated cardiac CT for functional analysis in adult congenital heart disease
title_sort feasibility of low radiation dose retrospectively-gated cardiac ct for functional analysis in adult congenital heart disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323633/
https://www.ncbi.nlm.nih.gov/pubmed/27865183
http://dx.doi.org/10.1016/j.ijcard.2016.11.108
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