The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness

BACKGROUND: Disruptor of telomeric silencing 1-like (DOT1L) is a non-SET domain containing methyltransferase known to catalyze mono-, di-, and tri-methylation of histone 3 on lysine 79 (H3K79me). DOT1L-mediated H3K79me has been implicated in chromatin-associated functions including gene transcriptio...

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Detalles Bibliográficos
Autores principales: Kari, Vijayalakshmi, Raul, Sanjay Kumar, Henck, Jana Maria, Kitz, Julia, Kramer, Frank, Kosinsky, Robyn Laura, Übelmesser, Nadine, Mansour, Wael Yassin, Eggert, Jessica, Spitzner, Melanie, Najafova, Zeynab, Bastians, Holger, Grade, Marian, Gaedcke, Jochen, Wegwitz, Florian, Johnsen, Steven A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323691/
https://www.ncbi.nlm.nih.gov/pubmed/30616689
http://dx.doi.org/10.1186/s13148-018-0601-1

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