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Activation of LncRNA TINCR by H3K27 acetylation promotes Trastuzumab resistance and epithelial-mesenchymal transition by targeting MicroRNA-125b in breast Cancer

BACKGROUND: Trastuzumab resistance followed by metastasis is a major obstacle for improving the clinical outcome of patients with advanced human epidermal growth factor receptor 2-positive (HER-2+) breast cancer. While long non-coding RNAs (lncRNAs) can modulate cell behavior, the contribution of th...

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Detalles Bibliográficos
Autores principales:	Dong, Huaying, Hu, Jianguo, Zou, Kejian, Ye, Mulin, Chen, Yuanwen, Wu, Chengyi, Chen, Xin, Han, Mingli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323810/ https://www.ncbi.nlm.nih.gov/pubmed/30621694 http://dx.doi.org/10.1186/s12943-018-0931-9

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