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Application potential of stem/progenitor cell-derived extracellular vesicles in renal diseases
Extracellular vesicles (EVs) are nanometer-sized and membrane-bound vesicles, including exosomes and microvesicles. EVs can deliver bioactive macromolecules such as proteins, lipids, and nucleic acids, allowing intercellular communication in multicellular organisms. EVs are secreted by all cell type...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323814/ https://www.ncbi.nlm.nih.gov/pubmed/30616603 http://dx.doi.org/10.1186/s13287-018-1097-5 |
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author | Sun, Xiao Meng, Huanyu Wan, Wuqing Xie, Min Wen, Chuan |
author_facet | Sun, Xiao Meng, Huanyu Wan, Wuqing Xie, Min Wen, Chuan |
author_sort | Sun, Xiao |
collection | PubMed |
description | Extracellular vesicles (EVs) are nanometer-sized and membrane-bound vesicles, including exosomes and microvesicles. EVs can deliver bioactive macromolecules such as proteins, lipids, and nucleic acids, allowing intercellular communication in multicellular organisms. EVs are secreted by all cell types including stem/progenitor cells. Stem/progenitor cell-derived EVs have been identified to exert immunomodulatory effects on target cells through transferring protein molecules as well as regulatory effects on the phenotype of target cells through fusion with the target cells membrane and/or through direct endocytosis by target cells to transfer nucleic acid substances (such as mRNA, miRNA) to the target cells. In both human and animal models, the use of stem/progenitor cells (such as bone marrow mesenchymal stromal cells) has been shown to promote the recovery of kidney diseases such as acute kidney injury and chronic kidney disease. Stem/progenitor cell-derived extracellular vesicles are an important mechanism by which stem/progenitor cells might repair kidney injury. Here, this review will discuss the latest advances concerning the application potential of stem/progenitor cell-derived extracellular vesicles in renal diseases, including the aspects as follows: anti-inflammatory, proliferation-promoting and anti-apoptotic, proangiogenic, antifibrotic and renal cancer progression-promoting. Therefore, stem/progenitor cell-derived extracellular vesicles may be a promising treatment tool for renal diseases. |
format | Online Article Text |
id | pubmed-6323814 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-63238142019-01-11 Application potential of stem/progenitor cell-derived extracellular vesicles in renal diseases Sun, Xiao Meng, Huanyu Wan, Wuqing Xie, Min Wen, Chuan Stem Cell Res Ther Review Extracellular vesicles (EVs) are nanometer-sized and membrane-bound vesicles, including exosomes and microvesicles. EVs can deliver bioactive macromolecules such as proteins, lipids, and nucleic acids, allowing intercellular communication in multicellular organisms. EVs are secreted by all cell types including stem/progenitor cells. Stem/progenitor cell-derived EVs have been identified to exert immunomodulatory effects on target cells through transferring protein molecules as well as regulatory effects on the phenotype of target cells through fusion with the target cells membrane and/or through direct endocytosis by target cells to transfer nucleic acid substances (such as mRNA, miRNA) to the target cells. In both human and animal models, the use of stem/progenitor cells (such as bone marrow mesenchymal stromal cells) has been shown to promote the recovery of kidney diseases such as acute kidney injury and chronic kidney disease. Stem/progenitor cell-derived extracellular vesicles are an important mechanism by which stem/progenitor cells might repair kidney injury. Here, this review will discuss the latest advances concerning the application potential of stem/progenitor cell-derived extracellular vesicles in renal diseases, including the aspects as follows: anti-inflammatory, proliferation-promoting and anti-apoptotic, proangiogenic, antifibrotic and renal cancer progression-promoting. Therefore, stem/progenitor cell-derived extracellular vesicles may be a promising treatment tool for renal diseases. BioMed Central 2019-01-08 /pmc/articles/PMC6323814/ /pubmed/30616603 http://dx.doi.org/10.1186/s13287-018-1097-5 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Sun, Xiao Meng, Huanyu Wan, Wuqing Xie, Min Wen, Chuan Application potential of stem/progenitor cell-derived extracellular vesicles in renal diseases |
title | Application potential of stem/progenitor cell-derived extracellular vesicles in renal diseases |
title_full | Application potential of stem/progenitor cell-derived extracellular vesicles in renal diseases |
title_fullStr | Application potential of stem/progenitor cell-derived extracellular vesicles in renal diseases |
title_full_unstemmed | Application potential of stem/progenitor cell-derived extracellular vesicles in renal diseases |
title_short | Application potential of stem/progenitor cell-derived extracellular vesicles in renal diseases |
title_sort | application potential of stem/progenitor cell-derived extracellular vesicles in renal diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323814/ https://www.ncbi.nlm.nih.gov/pubmed/30616603 http://dx.doi.org/10.1186/s13287-018-1097-5 |
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