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Application potential of stem/progenitor cell-derived extracellular vesicles in renal diseases

Extracellular vesicles (EVs) are nanometer-sized and membrane-bound vesicles, including exosomes and microvesicles. EVs can deliver bioactive macromolecules such as proteins, lipids, and nucleic acids, allowing intercellular communication in multicellular organisms. EVs are secreted by all cell type...

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Autores principales: Sun, Xiao, Meng, Huanyu, Wan, Wuqing, Xie, Min, Wen, Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323814/
https://www.ncbi.nlm.nih.gov/pubmed/30616603
http://dx.doi.org/10.1186/s13287-018-1097-5
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author Sun, Xiao
Meng, Huanyu
Wan, Wuqing
Xie, Min
Wen, Chuan
author_facet Sun, Xiao
Meng, Huanyu
Wan, Wuqing
Xie, Min
Wen, Chuan
author_sort Sun, Xiao
collection PubMed
description Extracellular vesicles (EVs) are nanometer-sized and membrane-bound vesicles, including exosomes and microvesicles. EVs can deliver bioactive macromolecules such as proteins, lipids, and nucleic acids, allowing intercellular communication in multicellular organisms. EVs are secreted by all cell types including stem/progenitor cells. Stem/progenitor cell-derived EVs have been identified to exert immunomodulatory effects on target cells through transferring protein molecules as well as regulatory effects on the phenotype of target cells through fusion with the target cells membrane and/or through direct endocytosis by target cells to transfer nucleic acid substances (such as mRNA, miRNA) to the target cells. In both human and animal models, the use of stem/progenitor cells (such as bone marrow mesenchymal stromal cells) has been shown to promote the recovery of kidney diseases such as acute kidney injury and chronic kidney disease. Stem/progenitor cell-derived extracellular vesicles are an important mechanism by which stem/progenitor cells might repair kidney injury. Here, this review will discuss the latest advances concerning the application potential of stem/progenitor cell-derived extracellular vesicles in renal diseases, including the aspects as follows: anti-inflammatory, proliferation-promoting and anti-apoptotic, proangiogenic, antifibrotic and renal cancer progression-promoting. Therefore, stem/progenitor cell-derived extracellular vesicles may be a promising treatment tool for renal diseases.
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spelling pubmed-63238142019-01-11 Application potential of stem/progenitor cell-derived extracellular vesicles in renal diseases Sun, Xiao Meng, Huanyu Wan, Wuqing Xie, Min Wen, Chuan Stem Cell Res Ther Review Extracellular vesicles (EVs) are nanometer-sized and membrane-bound vesicles, including exosomes and microvesicles. EVs can deliver bioactive macromolecules such as proteins, lipids, and nucleic acids, allowing intercellular communication in multicellular organisms. EVs are secreted by all cell types including stem/progenitor cells. Stem/progenitor cell-derived EVs have been identified to exert immunomodulatory effects on target cells through transferring protein molecules as well as regulatory effects on the phenotype of target cells through fusion with the target cells membrane and/or through direct endocytosis by target cells to transfer nucleic acid substances (such as mRNA, miRNA) to the target cells. In both human and animal models, the use of stem/progenitor cells (such as bone marrow mesenchymal stromal cells) has been shown to promote the recovery of kidney diseases such as acute kidney injury and chronic kidney disease. Stem/progenitor cell-derived extracellular vesicles are an important mechanism by which stem/progenitor cells might repair kidney injury. Here, this review will discuss the latest advances concerning the application potential of stem/progenitor cell-derived extracellular vesicles in renal diseases, including the aspects as follows: anti-inflammatory, proliferation-promoting and anti-apoptotic, proangiogenic, antifibrotic and renal cancer progression-promoting. Therefore, stem/progenitor cell-derived extracellular vesicles may be a promising treatment tool for renal diseases. BioMed Central 2019-01-08 /pmc/articles/PMC6323814/ /pubmed/30616603 http://dx.doi.org/10.1186/s13287-018-1097-5 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Sun, Xiao
Meng, Huanyu
Wan, Wuqing
Xie, Min
Wen, Chuan
Application potential of stem/progenitor cell-derived extracellular vesicles in renal diseases
title Application potential of stem/progenitor cell-derived extracellular vesicles in renal diseases
title_full Application potential of stem/progenitor cell-derived extracellular vesicles in renal diseases
title_fullStr Application potential of stem/progenitor cell-derived extracellular vesicles in renal diseases
title_full_unstemmed Application potential of stem/progenitor cell-derived extracellular vesicles in renal diseases
title_short Application potential of stem/progenitor cell-derived extracellular vesicles in renal diseases
title_sort application potential of stem/progenitor cell-derived extracellular vesicles in renal diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323814/
https://www.ncbi.nlm.nih.gov/pubmed/30616603
http://dx.doi.org/10.1186/s13287-018-1097-5
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