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LncRNA2Target v2.0: a comprehensive database for target genes of lncRNAs in human and mouse

Long non-coding RNAs (lncRNAs) play crucial roles in regulating gene expression, and a growing number of researchers have focused on the identification of target genes of lncRNAs. However, no online repository is available to collect the information on target genes regulated by lncRNAs. To make it c...

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Detalles Bibliográficos
Autores principales: Cheng, Liang, Wang, Pingping, Tian, Rui, Wang, Song, Guo, Qinghua, Luo, Meng, Zhou, Wenyang, Liu, Guiyou, Jiang, Huijie, Jiang, Qinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323902/
https://www.ncbi.nlm.nih.gov/pubmed/30380072
http://dx.doi.org/10.1093/nar/gky1051
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author Cheng, Liang
Wang, Pingping
Tian, Rui
Wang, Song
Guo, Qinghua
Luo, Meng
Zhou, Wenyang
Liu, Guiyou
Jiang, Huijie
Jiang, Qinghua
author_facet Cheng, Liang
Wang, Pingping
Tian, Rui
Wang, Song
Guo, Qinghua
Luo, Meng
Zhou, Wenyang
Liu, Guiyou
Jiang, Huijie
Jiang, Qinghua
author_sort Cheng, Liang
collection PubMed
description Long non-coding RNAs (lncRNAs) play crucial roles in regulating gene expression, and a growing number of researchers have focused on the identification of target genes of lncRNAs. However, no online repository is available to collect the information on target genes regulated by lncRNAs. To make it convenient for researchers to know what genes are regulated by a lncRNA of interest, we developed a database named lncRNA2Target to provide a comprehensive resource of lncRNA target genes in 2015. To update the database this year, we retrieved all new lncRNA–target relationships from papers published from 1 August 2014 to 30 April 2018 and RNA-seq datasets before and after knockdown or overexpression of a specific lncRNA. LncRNA2Target database v2.0 provides a web interface through which its users can search for the targets of a particular lncRNA or for the lncRNAs that target a particular gene, and is freely accessible at http://123.59.132.21/lncrna2target.
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spelling pubmed-63239022019-01-10 LncRNA2Target v2.0: a comprehensive database for target genes of lncRNAs in human and mouse Cheng, Liang Wang, Pingping Tian, Rui Wang, Song Guo, Qinghua Luo, Meng Zhou, Wenyang Liu, Guiyou Jiang, Huijie Jiang, Qinghua Nucleic Acids Res Database Issue Long non-coding RNAs (lncRNAs) play crucial roles in regulating gene expression, and a growing number of researchers have focused on the identification of target genes of lncRNAs. However, no online repository is available to collect the information on target genes regulated by lncRNAs. To make it convenient for researchers to know what genes are regulated by a lncRNA of interest, we developed a database named lncRNA2Target to provide a comprehensive resource of lncRNA target genes in 2015. To update the database this year, we retrieved all new lncRNA–target relationships from papers published from 1 August 2014 to 30 April 2018 and RNA-seq datasets before and after knockdown or overexpression of a specific lncRNA. LncRNA2Target database v2.0 provides a web interface through which its users can search for the targets of a particular lncRNA or for the lncRNAs that target a particular gene, and is freely accessible at http://123.59.132.21/lncrna2target. Oxford University Press 2019-01-08 2018-10-31 /pmc/articles/PMC6323902/ /pubmed/30380072 http://dx.doi.org/10.1093/nar/gky1051 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Database Issue
Cheng, Liang
Wang, Pingping
Tian, Rui
Wang, Song
Guo, Qinghua
Luo, Meng
Zhou, Wenyang
Liu, Guiyou
Jiang, Huijie
Jiang, Qinghua
LncRNA2Target v2.0: a comprehensive database for target genes of lncRNAs in human and mouse
title LncRNA2Target v2.0: a comprehensive database for target genes of lncRNAs in human and mouse
title_full LncRNA2Target v2.0: a comprehensive database for target genes of lncRNAs in human and mouse
title_fullStr LncRNA2Target v2.0: a comprehensive database for target genes of lncRNAs in human and mouse
title_full_unstemmed LncRNA2Target v2.0: a comprehensive database for target genes of lncRNAs in human and mouse
title_short LncRNA2Target v2.0: a comprehensive database for target genes of lncRNAs in human and mouse
title_sort lncrna2target v2.0: a comprehensive database for target genes of lncrnas in human and mouse
topic Database Issue
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323902/
https://www.ncbi.nlm.nih.gov/pubmed/30380072
http://dx.doi.org/10.1093/nar/gky1051
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