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Update of the FANTOM web resource: expansion to provide additional transcriptome atlases

The FANTOM web resource (http://fantom.gsc.riken.jp/) was developed to provide easy access to the data produced by the FANTOM project. It contains the most complete and comprehensive sets of actively transcribed enhancers and promoters in the human and mouse genomes. We determined the transcription...

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Autores principales: Lizio, Marina, Abugessaisa, Imad, Noguchi, Shuhei, Kondo, Atsushi, Hasegawa, Akira, Hon, Chung Chau, de Hoon, Michiel, Severin, Jessica, Oki, Shinya, Hayashizaki, Yoshihide, Carninci, Piero, Kasukawa, Takeya, Kawaji, Hideya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323950/
https://www.ncbi.nlm.nih.gov/pubmed/30407557
http://dx.doi.org/10.1093/nar/gky1099
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author Lizio, Marina
Abugessaisa, Imad
Noguchi, Shuhei
Kondo, Atsushi
Hasegawa, Akira
Hon, Chung Chau
de Hoon, Michiel
Severin, Jessica
Oki, Shinya
Hayashizaki, Yoshihide
Carninci, Piero
Kasukawa, Takeya
Kawaji, Hideya
author_facet Lizio, Marina
Abugessaisa, Imad
Noguchi, Shuhei
Kondo, Atsushi
Hasegawa, Akira
Hon, Chung Chau
de Hoon, Michiel
Severin, Jessica
Oki, Shinya
Hayashizaki, Yoshihide
Carninci, Piero
Kasukawa, Takeya
Kawaji, Hideya
author_sort Lizio, Marina
collection PubMed
description The FANTOM web resource (http://fantom.gsc.riken.jp/) was developed to provide easy access to the data produced by the FANTOM project. It contains the most complete and comprehensive sets of actively transcribed enhancers and promoters in the human and mouse genomes. We determined the transcription activities of these regulatory elements by CAGE (Cap Analysis of Gene Expression) for both steady and dynamic cellular states in all major and some rare cell types, consecutive stages of differentiation and responses to stimuli. We have expanded the resource by employing different assays, such as RNA-seq, short RNA-seq and a paired-end protocol for CAGE (CAGEscan), to provide new angles to study the transcriptome. That yielded additional atlases of long noncoding RNAs, miRNAs and their promoters. We have also expanded the CAGE analysis to cover rat, dog, chicken, and macaque species for a limited number of cell types. The CAGE data obtained from human and mouse were reprocessed to make them available on the latest genome assemblies. Here, we report the recent updates of both data and interfaces in the FANTOM web resource.
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spelling pubmed-63239502019-01-10 Update of the FANTOM web resource: expansion to provide additional transcriptome atlases Lizio, Marina Abugessaisa, Imad Noguchi, Shuhei Kondo, Atsushi Hasegawa, Akira Hon, Chung Chau de Hoon, Michiel Severin, Jessica Oki, Shinya Hayashizaki, Yoshihide Carninci, Piero Kasukawa, Takeya Kawaji, Hideya Nucleic Acids Res Database Issue The FANTOM web resource (http://fantom.gsc.riken.jp/) was developed to provide easy access to the data produced by the FANTOM project. It contains the most complete and comprehensive sets of actively transcribed enhancers and promoters in the human and mouse genomes. We determined the transcription activities of these regulatory elements by CAGE (Cap Analysis of Gene Expression) for both steady and dynamic cellular states in all major and some rare cell types, consecutive stages of differentiation and responses to stimuli. We have expanded the resource by employing different assays, such as RNA-seq, short RNA-seq and a paired-end protocol for CAGE (CAGEscan), to provide new angles to study the transcriptome. That yielded additional atlases of long noncoding RNAs, miRNAs and their promoters. We have also expanded the CAGE analysis to cover rat, dog, chicken, and macaque species for a limited number of cell types. The CAGE data obtained from human and mouse were reprocessed to make them available on the latest genome assemblies. Here, we report the recent updates of both data and interfaces in the FANTOM web resource. Oxford University Press 2019-01-08 2018-11-08 /pmc/articles/PMC6323950/ /pubmed/30407557 http://dx.doi.org/10.1093/nar/gky1099 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Database Issue
Lizio, Marina
Abugessaisa, Imad
Noguchi, Shuhei
Kondo, Atsushi
Hasegawa, Akira
Hon, Chung Chau
de Hoon, Michiel
Severin, Jessica
Oki, Shinya
Hayashizaki, Yoshihide
Carninci, Piero
Kasukawa, Takeya
Kawaji, Hideya
Update of the FANTOM web resource: expansion to provide additional transcriptome atlases
title Update of the FANTOM web resource: expansion to provide additional transcriptome atlases
title_full Update of the FANTOM web resource: expansion to provide additional transcriptome atlases
title_fullStr Update of the FANTOM web resource: expansion to provide additional transcriptome atlases
title_full_unstemmed Update of the FANTOM web resource: expansion to provide additional transcriptome atlases
title_short Update of the FANTOM web resource: expansion to provide additional transcriptome atlases
title_sort update of the fantom web resource: expansion to provide additional transcriptome atlases
topic Database Issue
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323950/
https://www.ncbi.nlm.nih.gov/pubmed/30407557
http://dx.doi.org/10.1093/nar/gky1099
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