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SymMap: an integrative database of traditional Chinese medicine enhanced by symptom mapping
Recently, the pharmaceutical industry has heavily emphasized phenotypic drug discovery (PDD), which relies primarily on knowledge about phenotype changes associated with diseases. Traditional Chinese medicine (TCM) provides a massive amount of information on natural products and the clinical symptom...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323958/ https://www.ncbi.nlm.nih.gov/pubmed/30380087 http://dx.doi.org/10.1093/nar/gky1021 |
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author | Wu, Yang Zhang, Feilong Yang, Kuo Fang, Shuangsang Bu, Dechao Li, Hui Sun, Liang Hu, Hairuo Gao, Kuo Wang, Wei Zhou, Xuezhong Zhao, Yi Chen, Jianxin |
author_facet | Wu, Yang Zhang, Feilong Yang, Kuo Fang, Shuangsang Bu, Dechao Li, Hui Sun, Liang Hu, Hairuo Gao, Kuo Wang, Wei Zhou, Xuezhong Zhao, Yi Chen, Jianxin |
author_sort | Wu, Yang |
collection | PubMed |
description | Recently, the pharmaceutical industry has heavily emphasized phenotypic drug discovery (PDD), which relies primarily on knowledge about phenotype changes associated with diseases. Traditional Chinese medicine (TCM) provides a massive amount of information on natural products and the clinical symptoms they are used to treat, which are the observable disease phenotypes that are crucial for clinical diagnosis and treatment. Curating knowledge of TCM symptoms and their relationships to herbs and diseases will provide both candidate leads and screening directions for evidence-based PDD programs. Therefore, we present SymMap, an integrative database of traditional Chinese medicine enhanced by symptom mapping. We manually curated 1717 TCM symptoms and related them to 499 herbs and 961 symptoms used in modern medicine based on a committee of 17 leading experts practicing TCM. Next, we collected 5235 diseases associated with these symptoms, 19 595 herbal constituents (ingredients) and 4302 target genes, and built a large heterogeneous network containing all of these components. Thus, SymMap integrates TCM with modern medicine in common aspects at both the phenotypic and molecular levels. Furthermore, we inferred all pairwise relationships among SymMap components using statistical tests to give pharmaceutical scientists the ability to rank and filter promising results to guide drug discovery. The SymMap database can be accessed at http://www.symmap.org/ and https://www.bioinfo.org/symmap. |
format | Online Article Text |
id | pubmed-6323958 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-63239582019-01-10 SymMap: an integrative database of traditional Chinese medicine enhanced by symptom mapping Wu, Yang Zhang, Feilong Yang, Kuo Fang, Shuangsang Bu, Dechao Li, Hui Sun, Liang Hu, Hairuo Gao, Kuo Wang, Wei Zhou, Xuezhong Zhao, Yi Chen, Jianxin Nucleic Acids Res Database Issue Recently, the pharmaceutical industry has heavily emphasized phenotypic drug discovery (PDD), which relies primarily on knowledge about phenotype changes associated with diseases. Traditional Chinese medicine (TCM) provides a massive amount of information on natural products and the clinical symptoms they are used to treat, which are the observable disease phenotypes that are crucial for clinical diagnosis and treatment. Curating knowledge of TCM symptoms and their relationships to herbs and diseases will provide both candidate leads and screening directions for evidence-based PDD programs. Therefore, we present SymMap, an integrative database of traditional Chinese medicine enhanced by symptom mapping. We manually curated 1717 TCM symptoms and related them to 499 herbs and 961 symptoms used in modern medicine based on a committee of 17 leading experts practicing TCM. Next, we collected 5235 diseases associated with these symptoms, 19 595 herbal constituents (ingredients) and 4302 target genes, and built a large heterogeneous network containing all of these components. Thus, SymMap integrates TCM with modern medicine in common aspects at both the phenotypic and molecular levels. Furthermore, we inferred all pairwise relationships among SymMap components using statistical tests to give pharmaceutical scientists the ability to rank and filter promising results to guide drug discovery. The SymMap database can be accessed at http://www.symmap.org/ and https://www.bioinfo.org/symmap. Oxford University Press 2019-01-08 2018-10-31 /pmc/articles/PMC6323958/ /pubmed/30380087 http://dx.doi.org/10.1093/nar/gky1021 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Database Issue Wu, Yang Zhang, Feilong Yang, Kuo Fang, Shuangsang Bu, Dechao Li, Hui Sun, Liang Hu, Hairuo Gao, Kuo Wang, Wei Zhou, Xuezhong Zhao, Yi Chen, Jianxin SymMap: an integrative database of traditional Chinese medicine enhanced by symptom mapping |
title | SymMap: an integrative database of traditional Chinese medicine enhanced by symptom mapping |
title_full | SymMap: an integrative database of traditional Chinese medicine enhanced by symptom mapping |
title_fullStr | SymMap: an integrative database of traditional Chinese medicine enhanced by symptom mapping |
title_full_unstemmed | SymMap: an integrative database of traditional Chinese medicine enhanced by symptom mapping |
title_short | SymMap: an integrative database of traditional Chinese medicine enhanced by symptom mapping |
title_sort | symmap: an integrative database of traditional chinese medicine enhanced by symptom mapping |
topic | Database Issue |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323958/ https://www.ncbi.nlm.nih.gov/pubmed/30380087 http://dx.doi.org/10.1093/nar/gky1021 |
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